ENSMUSG00000026357


Mus musculus

Features
Gene ID: ENSMUSG00000026357
  
Biological name :Rgs18
  
Synonyms : Q99PG4 / regulator of G-protein signaling 18 / Rgs18
  
Possible biological names infered from orthology : Q9NS28
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: F
Gene start: 144752683
Gene end: 144775435
  
Corresponding Affymetrix probe sets: 10358421 (MoGene1.0st)   1420398_at (Mouse Genome 430 2.0 Array)   1449856_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027603
NCBI entrez gene - 64214     See in Manteia.
MGI - MGI:1927498
RefSeq - NM_022881
RefSeq Peptide - NP_075019
swissprot - Q544K2
swissprot - Q99PG4
Ensembl - ENSMUSG00000026357
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rgs18ENSDARG00000036106Danio rerio
 RGS18ENSGALG00000021143Gallus gallus
 RGS18ENSG00000150681Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rgs2 / O08849 / Regulator of G-protein signaling 2 / P41220*ENSMUSG0000002636038
Rgs5 / O08850 / regulator of G-protein signaling 5 / O15539*ENSMUSG0000002667836
Rgs3 / Q9DC04 / regulator of G-protein signaling 3 / P49796*ENSMUSG0000005981035
Rgs4 / regulator of G protein signaling 4 / P49798*ENSMUSG0000003853034
Rgs8 / Q8BXT1 / Mus musculus regulator of G-protein signaling 8 (Rgs8), transcript variant 2, mRNA. / P57771* / regulator of G protein signaling 8*ENSMUSG0000004267134
Rgs1 / Q9JL25 / regulator of G-protein signaling 1 / Q08116*ENSMUSG0000002635832
Rgs16 / P97428 / regulator of G-protein signaling 16 / O15492*ENSMUSG0000002647532
Rgs21 / regulator of G protein signaling 21 / Q2M5E4*ENSMUSG0000009850930
Rgs20 / Q9QZB1 / regulator of G-protein signaling 20 / O76081*ENSMUSG0000000245929
Rgs19 / Q9CX84 / regulator of G-protein signaling 19 / P49795*ENSMUSG0000000245828
Rgs13 / Q8K443 / Regulator of G-protein signaling 13 / O14921*ENSMUSG0000005107927
Rgs17 / Q9QZB0 / regulator of G-protein signaling 17 / Q9UGC6*ENSMUSG0000001977526


Protein motifs (from Interpro)
Interpro ID Name
 IPR016137  RGS domain
 IPR024066  RGS, subdomain 1/3
 IPR034950  Regulator of G-protein signalling 18
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IPI
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway IDA
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IBA
 molecular_functionGO:0005096 GTPase activator activity IDA


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000229 abnormal megakaryocyte differentiation "atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nefltm2.1Liem/Nefl+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nefltm2.1Liem/Nefl+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nefltm2.1Liem/Nefl+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Nefltm2.1Liem/Nefl+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nefltm2.1Liem/Nefl+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129 * C57BL/6J

 MP:0005607 decreased bleeding time "less than the normal duration of blood flow after skin puncture; indicative of platement and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Dicer1tm1Mmk/Dicer1tm1Mmk,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129 * C57BL/6J

 MP:0008255 decreased megakaryocyte cell number "reduced number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Nefltm2.1Liem/Nefl+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0009586 increased platelet aggregation "increase in the ability of one platelet to one or more other platelets via adhesion molecules" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nefltm2.1Liem/Nefl+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Rgs18m1H/Rgs18m1H
Genetic Background: BALB/cAnN-Rgs18m1H/H

 MP:0009676 abnormal hemostasis "any anomaly in the spontaneous arrest of bleeding from vessels carrying blood under pressure or the arrest of circulation to an organ or part" [MESH:G09.188.124.560, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Rgs18m1H/Rgs18m1H
Genetic Background: BALB/cAnN-Rgs18m1H/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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