ENSMUSG00000059810


Mus musculus

Features
Gene ID: ENSMUSG00000059810
  
Biological name :Rgs3
  
Synonyms : Q9DC04 / regulator of G-protein signaling 3 / Rgs3
  
Possible biological names infered from orthology : P49796
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: B3
Gene start: 62559847
Gene end: 62704001
  
Corresponding Affymetrix probe sets: 10505326 (MoGene1.0st)   10607113 (MoGene1.0st)   1425296_a_at (Mouse Genome 430 2.0 Array)   1425701_a_at (Mouse Genome 430 2.0 Array)   1449516_a_at (Mouse Genome 430 2.0 Array)   1454026_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123310
Ensembl peptide - ENSMUSP00000065447
Ensembl peptide - ENSMUSP00000081569
Ensembl peptide - ENSMUSP00000095639
Ensembl peptide - ENSMUSP00000103043
Ensembl peptide - ENSMUSP00000103047
Ensembl peptide - ENSMUSP00000115192
Ensembl peptide - ENSMUSP00000116041
NCBI entrez gene - 50780     See in Manteia.
MGI - MGI:1354734
RefSeq - NM_134257
RefSeq - XM_006538058
RefSeq - XM_006538060
RefSeq - XM_006538064
RefSeq - XM_006538067
RefSeq - XM_006538068
RefSeq - XM_006538069
RefSeq - XM_006538070
RefSeq - XM_006538072
RefSeq - XM_011250065
RefSeq - XM_017320307
RefSeq - NM_001081650
RefSeq - NM_001310706
RefSeq - NM_019492
RefSeq - XM_006538057
RefSeq Peptide - NP_599018
RefSeq Peptide - NP_001075119
RefSeq Peptide - NP_001297635
RefSeq Peptide - NP_062365
swissprot - I7HJI7
swissprot - F6X4A2
swissprot - Z4YJQ4
swissprot - I7HPB2
swissprot - I7HFV2
swissprot - Q9DC04
Ensembl - ENSMUSG00000059810
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rgs3aENSDARG00000099746Danio rerio
 rgs3bENSDARG00000035132Danio rerio
 RGS3ENSGALG00000008881Gallus gallus
 RGS3ENSG00000138835Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rgs5 / O08850 / regulator of G-protein signaling 5 / O15539*ENSMUSG0000002667810
Rgs4 / regulator of G protein signaling 4 / P49798*ENSMUSG0000003853010
Rgs20 / Q9QZB1 / regulator of G-protein signaling 20 / O76081*ENSMUSG000000024599
Rgs2 / O08849 / Regulator of G-protein signaling 2 / P41220*ENSMUSG000000263609
Rgs16 / P97428 / regulator of G-protein signaling 16 / O15492*ENSMUSG000000264759
Rgs18 / Q99PG4 / regulator of G-protein signaling 18 / Q9NS28*ENSMUSG000000263578
Rgs1 / Q9JL25 / regulator of G-protein signaling 1 / Q08116*ENSMUSG000000263588
Rgs8 / Q8BXT1 / Mus musculus regulator of G-protein signaling 8 (Rgs8), transcript variant 2, mRNA. / P57771* / regulator of G protein signaling 8*ENSMUSG000000426718
Rgs19 / Q9CX84 / regulator of G-protein signaling 19 / P49795*ENSMUSG000000024587
Rgs17 / Q9QZB0 / regulator of G-protein signaling 17 / Q9UGC6*ENSMUSG000000197757
Rgs13 / Q8K443 / Regulator of G-protein signaling 13 / O14921*ENSMUSG000000510797
Rgs21 / regulator of G protein signaling 21 / Q2M5E4*ENSMUSG000000985097


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001478  PDZ domain
 IPR011993  PH-like domain superfamily
 IPR016137  RGS domain
 IPR024066  RGS, subdomain 1/3
 IPR034951  Regulator of G-protein signalling 3, RGS domain
 IPR035892  C2 domain superfamily
 IPR036034  PDZ superfamily
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Polbtm1.1Jbsw/Polb+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Polbtm1.1Jbsw/Polb+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Polbtm1.1Jbsw/Polb+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Polbtm1.1Jbsw/Polb+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Polbtm1.1Jbsw/Polb+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Polbtm1.1Jbsw/Polb+
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr