ENSMUSG00000026360


Mus musculus

Features
Gene ID: ENSMUSG00000026360
  
Biological name :Rgs2
  
Synonyms : O08849 / Regulator of G-protein signaling 2 / Rgs2
  
Possible biological names infered from orthology : P41220
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: F
Gene start: 143999338
Gene end: 144004161
  
Corresponding Affymetrix probe sets: 10358389 (MoGene1.0st)   1419247_at (Mouse Genome 430 2.0 Array)   1419248_at (Mouse Genome 430 2.0 Array)   1443250_at (Mouse Genome 430 2.0 Array)   1447830_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115558
Ensembl peptide - ENSMUSP00000140548
Ensembl peptide - ENSMUSP00000139964
NCBI entrez gene - 19735     See in Manteia.
MGI - MGI:1098271
RefSeq - NM_009061
RefSeq Peptide - NP_033087
swissprot - A0A087WRB0
swissprot - A0A087WPY2
swissprot - O08849
Ensembl - ENSMUSG00000026360
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rgs2ENSDARG00000098761Danio rerio
 RGS2ENSGALG00000042744Gallus gallus
 RGS2ENSG00000116741Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rgs18 / Q99PG4 / regulator of G-protein signaling 18 / Q9NS28*ENSMUSG0000002635742
Rgs3 / Q9DC04 / regulator of G-protein signaling 3 / P49796*ENSMUSG0000005981041
Rgs16 / P97428 / regulator of G-protein signaling 16 / O15492*ENSMUSG0000002647540
Rgs4 / regulator of G protein signaling 4 / P49798*ENSMUSG0000003853040
Rgs8 / Q8BXT1 / Mus musculus regulator of G-protein signaling 8 (Rgs8), transcript variant 2, mRNA. / P57771* / regulator of G protein signaling 8*ENSMUSG0000004267139
Rgs5 / O08850 / regulator of G-protein signaling 5 / O15539*ENSMUSG0000002667838
Rgs1 / Q9JL25 / regulator of G-protein signaling 1 / Q08116*ENSMUSG0000002635836
Rgs21 / regulator of G protein signaling 21 / Q2M5E4*ENSMUSG0000009850936
Rgs13 / Q8K443 / Regulator of G-protein signaling 13 / O14921*ENSMUSG0000005107931
Rgs19 / Q9CX84 / regulator of G-protein signaling 19 / P49795*ENSMUSG0000000245829
Rgs20 / Q9QZB1 / regulator of G-protein signaling 20 / O76081*ENSMUSG0000000245927
Rgs17 / Q9QZB0 / regulator of G-protein signaling 17 / Q9UGC6*ENSMUSG0000001977525


Protein motifs (from Interpro)
Interpro ID Name
 IPR016137  RGS domain
 IPR024066  RGS, subdomain 1/3
 IPR034947  Regulator of G-protein signalling 2
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007283 spermatogenesis IEP
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0010519 negative regulation of phospholipase activity IMP
 biological_processGO:0010614 negative regulation of cardiac muscle hypertrophy IMP
 biological_processGO:0031116 positive regulation of microtubule polymerization IEA
 biological_processGO:0043407 negative regulation of MAP kinase activity IMP
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0043951 negative regulation of cAMP-mediated signaling IMP
 biological_processGO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0050873 brown fat cell differentiation IDA
 biological_processGO:0055119 relaxation of cardiac muscle IMP
 biological_processGO:0060087 relaxation of vascular smooth muscle IMP
 biological_processGO:0060452 positive regulation of cardiac muscle contraction IMP
 biological_processGO:0140194 negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process IMP
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IMP
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0048487 beta-tubulin binding IEA


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000249 abnormal blood vessel physiology "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Eif2ak2tm1Cwe/Eif2ak2tm1Cwe
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000530 abnormal kidney vasculature "malformation or malfunctioning of the blood vessel network of the organ of excretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Eif2ak2tm1Cwe/Eif2ak2tm1Cwe
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Rgs2tm1Pngr/Rgs2+
Genetic Background: involves: C57BL/6J

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Eif2ak2tm1Cwe/Eif2ak2tm1Cwe
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Eif2ak2tm1Cwe/Eif2ak2tm1Cwe
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Eif2ak2tm1Cwe/Eif2ak2tm1Cwe
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Rgs2tm1Pngr/Rgs2+
Genetic Background: involves: C57BL/6J

 MP:0002844 aortic hypertrophy "increase in the bulk size of the aorta" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Eif2ak2tm1Cwe/Eif2ak2tm1Cwe
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003025 increased vascular smooth muscle contraction "greater ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Dckmemi/Dckmemi
Genetic Background: C57BL/6J-Dckmemi

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rgs2tm1.1Kjb/Rgs2tm1.1Kjb,Tg(Tek-cre/ERT2)1Arnd/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Eif2ak2tm1Cwe/Eif2ak2tm1Cwe
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005591 decreased vasodilation "less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dckmemi/Dckmemi
Genetic Background: C57BL/6J-Dckmemi

Allelic Composition: Rgs2tm1.1Kjb/Rgs2tm1.1Kjb,Tg(Tek-cre/ERT2)1Arnd/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0005656 decreased aggression "when compared to controls, subjects exhibit less than the normal level of domineering, assaultive posture and/or hostile physical action" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Eif2ak2tm1Cwe/Eif2ak2tm1Cwe
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008263 abnormal hippocampus CA1 region morphology 
Show

Allelic Composition: Eif2ak2tm1Cwe/Eif2ak2tm1Cwe
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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