ENSMUSG00000026475


Mus musculus

Features
Gene ID: ENSMUSG00000026475
  
Biological name :Rgs16
  
Synonyms : P97428 / regulator of G-protein signaling 16 / Rgs16
  
Possible biological names infered from orthology : O15492
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: G3
Gene start: 153740349
Gene end: 153745468
  
Corresponding Affymetrix probe sets: 10350733 (MoGene1.0st)   1426037_a_at (Mouse Genome 430 2.0 Array)   1451452_a_at (Mouse Genome 430 2.0 Array)   1455265_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027748
NCBI entrez gene - 19734     See in Manteia.
MGI - MGI:108407
RefSeq - NM_011267
RefSeq Peptide - NP_035397
swissprot - P97428
swissprot - Q542U0
Ensembl - ENSMUSG00000026475
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rgs8ENSDARG00000070037Danio rerio
 RGS16ENSGALG00000033535Gallus gallus
 RGS16ENSG00000143333Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rgs8 / Q8BXT1 / Mus musculus regulator of G-protein signaling 8 (Rgs8), transcript variant 2, mRNA. / P57771* / regulator of G protein signaling 8*ENSMUSG0000004267148
Rgs5 / O08850 / regulator of G-protein signaling 5 / O15539*ENSMUSG0000002667845
Rgs4 / regulator of G protein signaling 4 / P49798*ENSMUSG0000003853045
Rgs3 / Q9DC04 / regulator of G-protein signaling 3 / P49796*ENSMUSG0000005981044
Rgs2 / O08849 / Regulator of G-protein signaling 2 / P41220*ENSMUSG0000002636042
Rgs18 / Q99PG4 / regulator of G-protein signaling 18 / Q9NS28*ENSMUSG0000002635737
Rgs1 / Q9JL25 / regulator of G-protein signaling 1 / Q08116*ENSMUSG0000002635833
Rgs21 / regulator of G protein signaling 21 / Q2M5E4*ENSMUSG0000009850933
Rgs19 / Q9CX84 / regulator of G-protein signaling 19 / P49795*ENSMUSG0000000245832
Rgs20 / Q9QZB1 / regulator of G-protein signaling 20 / O76081*ENSMUSG0000000245931
Rgs13 / Q8K443 / Regulator of G-protein signaling 13 / O14921*ENSMUSG0000005107930
Rgs17 / Q9QZB0 / regulator of G-protein signaling 17 / Q9UGC6*ENSMUSG0000001977527


Protein motifs (from Interpro)
Interpro ID Name
 IPR016137  RGS domain
 IPR024066  RGS, subdomain 1/3
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031224 intrinsic component of membrane IDA
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002500 granulomatous inflammation "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Myd88tm1Hlz/Myd88tm1Hlz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Myd88tm1Hlz Lyz2tm1(cre)Ifo

 MP:0002575 increased circulating ketone body level "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]
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Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myd88tm1Hlz/Myd88tm1Hlz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Myd88tm1Hlz Lyz2tm1(cre)Ifo

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Myd88tm1Hlz/Myd88tm1Hlz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Myd88tm1Hlz Lyz2tm1(cre)Ifo

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myd88tm1Hlz/Myd88tm1Hlz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Myd88tm1Hlz Lyz2tm1(cre)Ifo

 MP:0006050 pulmonary fibrosis "formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myd88tm1Hlz/Myd88tm1Hlz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Myd88tm1Hlz Lyz2tm1(cre)Ifo

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Myd88tm1Hlz/Myd88tm1Hlz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Myd88tm1Hlz Lyz2tm1(cre)Ifo

 MP:0008672 increased interleukin-13 secretion "increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Myd88tm1Hlz/Myd88tm1Hlz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Myd88tm1Hlz Lyz2tm1(cre)Ifo

 MP:0008702 increased interleukin-5 secretion "increase in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
Show

Allelic Composition: Myd88tm1Hlz/Myd88tm1Hlz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129P2-Myd88tm1Hlz Lyz2tm1(cre)Ifo

 MP:0014171 increased fatty acid oxidation "increased rate or incidence of the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen" [GO:0019395]
Show

Allelic Composition: Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

 MP:0020469 prolonged circadian behavior period "increase in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
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Allelic Composition: Nedd4ltm1Shkr/Nedd4ltm1Shkr
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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