ENSMUSG00000038530


Mus musculus

Features
Gene ID: ENSMUSG00000038530
  
Biological name :Rgs4
  
Synonyms : regulator of G protein signaling 4 / Rgs4
  
Possible biological names infered from orthology : P49798
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H2.3
Gene start: 169741477
Gene end: 169747642
  
Corresponding Affymetrix probe sets: 10359908 (MoGene1.0st)   1416286_at (Mouse Genome 430 2.0 Array)   1416287_at (Mouse Genome 430 2.0 Array)   1448285_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106989
Ensembl peptide - ENSMUSP00000027991
NCBI entrez gene - 19736     See in Manteia.
MGI - MGI:108409
RefSeq - NM_009062
RefSeq Peptide - NP_033088
swissprot - D3YXR2
swissprot - Q5D078
Ensembl - ENSMUSG00000038530
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rgs4ENSDARG00000070047Danio rerio
 RGS4ENSGALG00000002564Gallus gallus
 RGS4ENSG00000117152Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rgs3 / Q9DC04 / regulator of G-protein signaling 3 / P49796*ENSMUSG0000005981047
Rgs5 / O08850 / regulator of G-protein signaling 5 / O15539*ENSMUSG0000002667846
Rgs16 / P97428 / regulator of G-protein signaling 16 / O15492*ENSMUSG0000002647544
Rgs8 / Q8BXT1 / Mus musculus regulator of G-protein signaling 8 (Rgs8), transcript variant 2, mRNA. / P57771* / regulator of G protein signaling 8*ENSMUSG0000004267143
Rgs2 / O08849 / Regulator of G-protein signaling 2 / P41220*ENSMUSG0000002636041
Rgs18 / Q99PG4 / regulator of G-protein signaling 18 / Q9NS28*ENSMUSG0000002635740
Rgs1 / Q9JL25 / regulator of G-protein signaling 1 / Q08116*ENSMUSG0000002635837
Rgs13 / Q8K443 / Regulator of G-protein signaling 13 / O14921*ENSMUSG0000005107934
Rgs19 / Q9CX84 / regulator of G-protein signaling 19 / P49795*ENSMUSG0000000245833
Rgs21 / regulator of G protein signaling 21 / Q2M5E4*ENSMUSG0000009850933
Rgs20 / Q9QZB1 / regulator of G-protein signaling 20 / O76081*ENSMUSG0000000245932
Rgs17 / Q9QZB0 / regulator of G-protein signaling 17 / Q9UGC6*ENSMUSG0000001977526


Protein motifs (from Interpro)
Interpro ID Name
 IPR016137  RGS domain
 IPR024066  RGS, subdomain 1/3
 IPR034952  Regulator of G-protein signalling 4
 IPR034953  Regulator of G-protein signalling 4, RGS domain
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IEA
 molecular_functionGO:0005096 GTPase activator activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000440 domed skull 
Show

Allelic Composition: m3Bei/m3Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

Allelic Composition: m5Bei/m5Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

Allelic Composition: Drc3m6Bei/Drc3m6Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: m3Bei/m3Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mad2l2tm1Ymu/Mad2l2tm1Ymu
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

Allelic Composition: m3Bei/m3Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: m3Bei/m3Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

Allelic Composition: m5Bei/m5Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

Allelic Composition: Drc3m6Bei/Drc3m6Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Gja8Lop10/Gja8Lop10
Genetic Background: C;AK-Gja8Lop10/J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Adgra2tm1.2Bstc/Adgra2tm1.2Bstc
Genetic Background: B6.Cg-Adgra2tm1.2Bstc

Allelic Composition: Fmr1tm1Cgr/Fmr1tm1Cgr,Rgs4tm1Dgen/Rgs4tm1Dgen
Genetic Background: B6.129P2-Rgs4tm1Dgen Fmr1tm1Cgr

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gja8Lop10/Gja8Lop10
Genetic Background: C;AK-Gja8Lop10/J

 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Adgra2tm1.2Bstc/Adgra2tm1.2Bstc
Genetic Background: B6.Cg-Adgra2tm1.2Bstc

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Relnctrdel/Relnctrdel,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

Allelic Composition: m3Bei/m3Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0001968 abnormal touch/ nociception "change in the ability to sense contact with objects or in the ability to sense pain, most often registered by mechanoreceptors in the skin and mucous membranes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gja8Lop10/Gja8Lop10
Genetic Background: C;AK-Gja8Lop10/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkdcscid/Prkdcscid,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adgra2tm1.2Bstc/Adgra2tm1.2Bstc
Genetic Background: B6.Cg-Adgra2tm1.2Bstc

Allelic Composition: Fmr1tm1Cgr/Fmr1tm1Cgr,Rgs4tm1Dgen/Rgs4tm1Dgen
Genetic Background: B6.129P2-Rgs4tm1Dgen Fmr1tm1Cgr

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: En1tm2(cre)Wrst/En1+,Tor1atm2Wtd/Tor1atm3.1Wtd
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * SJL

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
Show

Allelic Composition: m3Bei/m3Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0003863 decreased aggression towards mice "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards other mice" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Adgra2tm1.2Bstc/Adgra2tm1.2Bstc
Genetic Background: B6.Cg-Adgra2tm1.2Bstc

 MP:0004851 increased testis weight "greater average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fmr1tm1Cgr/Fmr1tm1Cgr,Rgs4tm1Dgen/Rgs4tm1Dgen
Genetic Background: B6.129P2-Rgs4tm1Dgen Fmr1tm1Cgr

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

 MP:0005526 decreased renal plasma flow rate "less than the normal volume of plasma passing throught the kidney per unit time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Nle1rs2820949-G/Nle1rs2820949-G
Genetic Background: C57BL/6J

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: En1tm2(cre)Wrst/En1+,Tor1atm2Wtd/Tor1atm3.1Wtd
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * SJL

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: m3Bei/m3Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

Allelic Composition: m5Bei/m5Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

Allelic Composition: Drc3m6Bei/Drc3m6Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0008283 small hippocampus "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: m3Bei/m3Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

Allelic Composition: Drc3m6Bei/Drc3m6Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

Allelic Composition: m3Bei/m3Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

Allelic Composition: Dnaaf1m4Bei/Dnaaf1m4Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

Allelic Composition: m5Bei/m5Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

Allelic Composition: Drc3m6Bei/Drc3m6Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0009712 impaired conditioned place preference behavior "decrease in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgra2tm1.2Bstc/Adgra2tm1.2Bstc
Genetic Background: B6.Cg-Adgra2tm1.2Bstc

 MP:0009757 impaired behavioral response to morphine "decreased sensitivity to morphine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gja8Lop10/Gja8Lop10
Genetic Background: C;AK-Gja8Lop10/J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: En1tm2(cre)Wrst/En1+,Tor1atm2Wtd/Tor1atm3.1Wtd
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * SJL

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nle1rs2820949-G/Nle1rs2820949-G
Genetic Background: C57BL/6J

 MP:0009776 decreased behavioral withdrawal response "decrease in the intensity or duration of behaviors displayed after discontinuation of an addictive substance" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gja8Lop10/Gja8Lop10
Genetic Background: C;AK-Gja8Lop10/J

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

 MP:0010760 abnormal macrophage chemotaxis "anomaly in the movement of a macrophage guided by a specific chemical concentration gradient" [GO:0048246]
Show

Allelic Composition: En1tm2(cre)Wrst/En1+,Tor1atm2Wtd/Tor1atm3.1Wtd
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dnaaf1m4Bei/Dnaaf1m4Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

Allelic Composition: m5Bei/m5Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

Allelic Composition: Drc3m6Bei/Drc3m6Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0011107 partial embryonic lethality before turning of embryo "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Gja8Lop10/Gja8Lop10
Genetic Background: C;AK-Gja8Lop10/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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