ENSMUSG00000032207


Mus musculus

Features
Gene ID: ENSMUSG00000032207
  
Biological name :Lipc
  
Synonyms : Hepatic triacylglycerol lipase / Lipc / P27656
  
Possible biological names infered from orthology : lipase C, hepatic type / P11150
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: D
Gene start: 70798128
Gene end: 70952226
  
Corresponding Affymetrix probe sets: 10594812 (MoGene1.0st)   1419560_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034731
Ensembl peptide - ENSMUSP00000149185
Ensembl peptide - ENSMUSP00000149638
NCBI entrez gene - 15450     See in Manteia.
MGI - MGI:96216
RefSeq - XM_006510817
RefSeq - NM_001324472
RefSeq - NM_001324473
RefSeq - NM_008280
RefSeq - XM_006510816
RefSeq Peptide - NP_001311402
RefSeq Peptide - NP_032306
RefSeq Peptide - NP_001311401
swissprot - P27656
swissprot - Q3TYU0
swissprot - A0A1L1SRU8
Ensembl - ENSMUSG00000032207
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lipcaENSDARG00000053476Danio rerio
 lipcbENSDARG00000090486Danio rerio
 LIPCENSGALG00000004230Gallus gallus
 LIPCENSG00000166035Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lipg / Q9WVG5 / Endothelial lipase / Q9Y5X9* / lipase G, endothelial type*ENSMUSG0000005384641
Lpl / P11152 / lipoprotein lipase / P06858*ENSMUSG0000001556840
Q5BKQ4 / Pnliprp1 / pancreatic lipase related protein 1 / P54315*ENSMUSG0000004217926
P17892 / Pnliprp2 / pancreatic lipase-related protein 2 / pancreatic lipase related protein 2 (gene/pseudogene)*ENSMUSG0000002509125
Pnlip / Q6P8U6 / pancreatic lipase / P16233*ENSMUSG0000004600825
Liph / Q8CIV3 / Lipase member H / Q8WWY8* / lipase H*ENSMUSG0000004462624
Pla1a / Q8VI78 / Phospholipase A1 member A / Q53H76*ENSMUSG0000000284723
Lipi / lipase I / Q6XZB0*ENSMUSG0000003294823


Protein motifs (from Interpro)
Interpro ID Name
 IPR000734  Triacylglycerol lipase family
 IPR001024  PLAT/LH2 domain
 IPR002333  Hepatic lipase
 IPR013818  Lipase/vitellogenin
 IPR016272  Lipase, LIPH-type
 IPR029058  Alpha/Beta hydrolase fold
 IPR033906  Lipase, N-terminal
 IPR036392  PLAT/LH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0008203 cholesterol metabolic process IGI
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0019433 triglyceride catabolic process IEA
 biological_processGO:0030301 cholesterol transport IMP
 biological_processGO:0034372 very-low-density lipoprotein particle remodeling IEA
 biological_processGO:0034374 low-density lipoprotein particle remodeling IEA
 biological_processGO:0034375 high-density lipoprotein particle remodeling IEA
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0070328 triglyceride homeostasis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0034364 high-density lipoprotein particle IEA
 molecular_functionGO:0004806 triglyceride lipase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0016298 lipase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Assembly of active LPL and LIPC lipase complexes
Chylomicron clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000180 abnormal circulating cholesterol level "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

Allelic Composition: Lipctm1Unc/Lipctm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Lipctm1Unc/Lipctm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Lipctm1Unc/Lipctm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nos2tm1Lau/Nos2tm1Lau,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc Nos2tm1Lau

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Oca2p/Oca2p-8FDFoD
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

Allelic Composition: Lipctm1Unc/Lipctm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Lipctm1Unc/Lipctm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: E2f4tm1Lees/E2f4+,Rb1tm1Tyj/Rb1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lipctm1Unc/Lipctm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002665 decreased circulating corticosterone level "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Oca2p/Oca2p-8FDFoD
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Lipctm1Unc/Lipctm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0003355 reduced ovulation "reduction in the frequency in which an ovum is released from a rupturing ovarian follicle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lipctm1Unc/Lipctm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

Allelic Composition: Lipctm1Unc/Lipctm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Lipctm1Unc/Lipctm1Unc
Genetic Background: B6.129P2-Lipctm1Unc

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Lipctm1Unc/Lipctm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0006084 abnormal circulating phospholipid level "anomalous concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
Show

Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

Allelic Composition: Lipctm1Unc/Lipctm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032207 Lipc / P27656 / Hepatic triacylglycerol lipase / P11150* / lipase C, hepatic type*  / complex
 ENSMUSG00000002279 Lmf1 / Q3U3R4 / Lipase maturation factor 1 / Q96S06*  / complex / reaction






 

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