ENSMUSG00000045287


Mus musculus

Features
Gene ID: ENSMUSG00000045287
  
Biological name :Rtn4rl1
  
Synonyms : Q8K0S5 / Reticulon-4 receptor-like 1 / Rtn4rl1
  
Possible biological names infered from orthology : Q86UN2
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B5
Gene start: 75193783
Gene end: 75267769
  
Corresponding Affymetrix probe sets: 10378549 (MoGene1.0st)   1436868_at (Mouse Genome 430 2.0 Array)   1455664_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099572
NCBI entrez gene - 237847     See in Manteia.
MGI - MGI:2661375
RefSeq - NM_177708
RefSeq Peptide - NP_808376
swissprot - Q8K0S5
Ensembl - ENSMUSG00000045287
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rtn4rl1aENSDARG00000007856Danio rerio
 rtn4rl1bENSDARG00000098528Danio rerio
 RTN4RL1ENSGALG00000021589Gallus gallus
 Q86UN2ENSG00000185924Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q7M6Z0 / Rtn4rl2 / Reticulon-4 receptor-like 2 / Q86UN3*ENSMUSG0000005089644
Rtn4r / Q99PI8 / Reticulon-4 receptor / Q9BZR6*ENSMUSG0000004381138
Lrrc24 / Q8BHA1 / Leucine-rich repeat-containing protein 24 / Q50LG9* / leucine rich repeat containing 24*ENSMUSG0000003370722
Lrrc26 / Q91W20 / Leucine-rich repeat-containing protein 26 / Q2I0M4* / leucine rich repeat containing 26*ENSMUSG0000002696118
A2VDH3 / Lrrc38 / Leucine-rich repeat-containing protein 38 / Q5VT99* / leucine rich repeat containing 38*ENSMUSG0000002858416
Lrrc52 / Q5M8M9 / Leucine-rich repeat-containing protein 52 / Q8N7C0* / leucine rich repeat containing 52*ENSMUSG0000004048516
Lrtm1 / Q8BXQ3 / Leucine-rich repeat and transmembrane domain-containing protein 1 / Q9HBL6* / leucine rich repeats and transmembrane domains 1*ENSMUSG0000004577616
Lrtm2 / Q8BGX3 / Leucine-rich repeat and transmembrane domain-containing protein 2 / Q8N967* / leucine rich repeats and transmembrane domains 2*ENSMUSG0000005500316
Lrrc55 / Q3UY51 / Leucine-rich repeat-containing protein 55 / Q6ZSA7* / leucine rich repeat containing 55*ENSMUSG0000007522416


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0010977 negative regulation of neuron projection development IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0022038 corpus callosum development IMP
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0048681 negative regulation of axon regeneration IMP
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0046658 anchored component of plasma membrane IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008201 heparin binding IMP
 molecular_functionGO:0035374 chondroitin sulfate binding IDA


Pathways (from Reactome)
Pathway description
Post-translational modification: synthesis of GPI-anchored proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Atp1a1Gt(OST31117)Lex/Atp1a1Gt(OST31117)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp1a1Gt(OST31117)Lex/Atp1a1Gt(OST31117)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002928 abnormal bile duct morphology "malformation of the channels that secrete bile from the liver to the gall bladder and intestines" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Atp1a1Gt(OST31117)Lex/Atp1a1Gt(OST31117)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Notch3tm1.1Dwr/Notch3+
Genetic Background: involves: 129S/SvEv * Swiss

 MP:0030013 improved central nervous system regeneration "faster or more complete regeneration of healthy central nervous system tissue following injury or disease" [] {comment="MGI:anna"}
Show

Allelic Composition: Rtn4rtm1.1Pado/Rtn4rtm1.1Pado,Rtn4rl1tm1.1Rojg/Rtn4rl1tm1.1Rojg,Rtn4rl2tm1.1Pado/Rtn4rl2tm1.1Pado
Genetic Background: involves: 129S/SvEvBrd * 129S4/SvJae

Allelic Composition: Rtn4rtm1.1Pado/Rtn4rtm1.1Pado,Rtn4rl1tm1.1Rojg/Rtn4rl1tm1.1Rojg
Genetic Background: involves: 129S/SvEvBrd * 129S4/SvJae

Allelic Composition: Ptprstm1Mtr/Ptprstm1Mtr,Rtn4rtm1.1Pado/Rtn4rtm1.1Pado,Rtn4rl1tm1.1Rojg/Rtn4rl1tm1.1Rojg
Genetic Background: involves: 129S/SvEvBrd * 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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