ENSMUSG00000050896


Mus musculus

Features
Gene ID: ENSMUSG00000050896
  
Biological name :Rtn4rl2
  
Synonyms : Q7M6Z0 / Reticulon-4 receptor-like 2 / Rtn4rl2
  
Possible biological names infered from orthology : Q86UN3
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: D
Gene start: 84871924
Gene end: 84886710
  
Corresponding Affymetrix probe sets: 10484482 (MoGene1.0st)   1439573_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118362
Ensembl peptide - ENSMUSP00000057725
NCBI entrez gene - 269295     See in Manteia.
MGI - MGI:2669796
RefSeq - NM_199223
RefSeq - XM_006499596
RefSeq Peptide - NP_954693
swissprot - A2ATS6
swissprot - Q7M6Z0
Ensembl - ENSMUSG00000050896
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rtn4rl2aENSDARG00000052012Danio rerio
 rtn4rl2bENSDARG00000037495Danio rerio
 RTN4RL2ENSGALG00000032903Gallus gallus
 Q86UN3ENSG00000186907Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8K0S5 / Rtn4rl1 / Reticulon-4 receptor-like 1 / Q86UN2*ENSMUSG0000004528747
Rtn4r / Q99PI8 / Reticulon-4 receptor / Q9BZR6*ENSMUSG0000004381139
Lrrc24 / Q8BHA1 / Leucine-rich repeat-containing protein 24 / Q50LG9* / leucine rich repeat containing 24*ENSMUSG0000003370725
Lrtm2 / Q8BGX3 / Leucine-rich repeat and transmembrane domain-containing protein 2 / Q8N967* / leucine rich repeats and transmembrane domains 2*ENSMUSG0000005500321
Lrrc55 / Q3UY51 / Leucine-rich repeat-containing protein 55 / Q6ZSA7* / leucine rich repeat containing 55*ENSMUSG0000007522421
Lrrc26 / Q91W20 / Leucine-rich repeat-containing protein 26 / Q2I0M4* / leucine rich repeat containing 26*ENSMUSG0000002696120
A2VDH3 / Lrrc38 / Leucine-rich repeat-containing protein 38 / Q5VT99* / leucine rich repeat containing 38*ENSMUSG0000002858419
Lrtm1 / Q8BXQ3 / Leucine-rich repeat and transmembrane domain-containing protein 1 / Q9HBL6* / leucine rich repeats and transmembrane domains 1*ENSMUSG0000004577618
Lrrc52 / Q5M8M9 / Leucine-rich repeat-containing protein 52 / Q8N7C0* / leucine rich repeat containing 52*ENSMUSG0000004048515


Protein motifs (from Interpro)
Interpro ID Name
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0022038 corpus callosum development IMP
 biological_processGO:0031103 axon regeneration TAS
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030424 axon ISS
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043204 perikaryon ISS
 cellular_componentGO:0045121 membrane raft ISS
 cellular_componentGO:0046658 anchored component of plasma membrane IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Post-translational modification: synthesis of GPI-anchored proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp1a1Gt(OST31117)Lex/Atp1a1Gt(OST31117)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Rtn4rl2tm1Yanr/Rtn4rl2tm1Yanr
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003329 amyloid beta deposits 
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Allelic Composition: Rtn4rl2tm1Yanr/Rtn4rl2tm1Yanr
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Notch3tm1.1Dwr/Notch3+
Genetic Background: involves: 129S/SvEv * Swiss

 MP:0030013 improved central nervous system regeneration "faster or more complete regeneration of healthy central nervous system tissue following injury or disease" [] {comment="MGI:anna"}
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Allelic Composition: Notch3tm1.1Dwr/Notch3+
Genetic Background: involves: 129S/SvEv * Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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