ENSMUSG00000048120


Mus musculus

Features
Gene ID: ENSMUSG00000048120
  
Biological name :Entpd1
  
Synonyms : Ectonucleoside triphosphate diphosphohydrolase 1 / Entpd1 / P55772
  
Possible biological names infered from orthology : AL365273.2 / P49961
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C3
Gene start: 40612366
Gene end: 40741602
  
Corresponding Affymetrix probe sets: 10463070 (MoGene1.0st)   1423326_at (Mouse Genome 430 2.0 Array)   1450939_at (Mouse Genome 430 2.0 Array)   1453586_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107850
Ensembl peptide - ENSMUSP00000116349
Ensembl peptide - ENSMUSP00000116895
Ensembl peptide - ENSMUSP00000117213
Ensembl peptide - ENSMUSP00000116285
NCBI entrez gene - 12495     See in Manteia.
MGI - MGI:102805
RefSeq - XM_017318047
RefSeq - NM_001304721
RefSeq - NM_009848
RefSeq - XM_006526618
RefSeq - XM_006526619
RefSeq - XM_006526620
RefSeq Peptide - NP_033978
RefSeq Peptide - NP_001291650
swissprot - Q544U5
swissprot - F7B9M9
swissprot - D6RHQ2
swissprot - Q8CDV7
swissprot - D6RFA9
swissprot - P55772
Ensembl - ENSMUSG00000048120
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 entpd1ENSDARG00000045066Danio rerio
 ENTPD1ENSGALG00000007078Gallus gallus
 AL365273.2ENSG00000270099Homo sapiens
 ENTPD1ENSG00000138185Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Entpd8 / Q8K0L2 / Ectonucleoside triphosphate diphosphohydrolase 8 / Q5MY95*ENSMUSG0000003681339
Entpd2 / O55026 / Ectonucleoside triphosphate diphosphohydrolase 2 / Q9Y5L3*ENSMUSG0000001508538
Entpd3 / ectonucleoside triphosphate diphosphohydrolase 3 / O75355*ENSMUSG0000004160835
Q9DBT4 / Entpd4b / Ectonucleoside triphosphate diphosphohydrolase 4 / ENTPD4* / Q9Y227*ENSMUSG0000002206624
Entpd4 / Q9DBT4 / Ectonucleoside triphosphate diphosphohydrolase 4 / Q9Y227*ENSMUSG0000009546324
Entpd7 / Q3TCT4 / Ectonucleoside triphosphate diphosphohydrolase 7 / Q9NQZ7*ENSMUSG0000002519223


Protein motifs (from Interpro)
Interpro ID Name
 IPR000407  Nucleoside phosphatase GDA1/CD39


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IDA
 biological_processGO:0009181 purine ribonucleoside diphosphate catabolic process IDA
 biological_processGO:0030168 platelet activation IDA
 cellular_componentGO:0005605 basal lamina IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017110 nucleoside-diphosphatase activity ISO
 molecular_functionGO:0017111 nucleoside-triphosphatase activity ISO
 molecular_functionGO:0102485 dATP phosphohydrolase activity IEA
 molecular_functionGO:0102486 dCTP phosphohydrolase activity IEA
 molecular_functionGO:0102487 dUTP phosphohydrolase activity IEA
 molecular_functionGO:0102488 dTTP phosphohydrolase activity IEA
 molecular_functionGO:0102489 GTP phosphohydrolase activity IEA
 molecular_functionGO:0102490 8-oxo-dGTP phosphohydrolase activity IEA
 molecular_functionGO:0102491 dGTP phosphohydrolase activity IEA


Pathways (from Reactome)
Pathway description
Phosphate bond hydrolysis by NTPDase proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000233 abnormal blood flow velocity "anomalous rate of flow of the blood through vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgf3tm1.1Sms/Fgf3tm1.1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000740 impaired smooth muscle contractility "inability or reduced ability of the smooth muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cyb5atm1Wolf/Cyb5atm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Fgf3tm1.1Sms/Fgf3tm1.1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgf3tm1.1Sms/Fgf3tm1.1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002965 hyperalbuminemia "blood albumin concentration above the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

 MP:0003019 increased circulating chloride level "elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

 MP:0003062 abnormal coping response "altered ability to respond productively to a stressful situation or stimulus, or failure to seek pleasurable stimuli" [RGD:Rat Genome Database submission]
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Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0003076 increased susceptibility to ischemic brain injury "increased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [J:90111, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129X1/SvJ

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fgf3tm1.1Sms/Fgf3tm1.1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Fgf3tm1.1Sms/Fgf3tm1.1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Entpd1tm1b(EUCOMM)Wtsi/Entpd1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Entpd1tm1b(EUCOMM)Wtsi/Ieg

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Fgf3tm1.1Sms/Fgf3tm1.1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003442 decreased circulating glycerol level "lower than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0003985 renal fibrosis "formation of fibrous tissue in the kidney as a result of repair or a reactive process" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf3tm1.1Sms/Fgf3tm1.1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004003 abnormal vascular endothelial cell physiology "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fgf3tm1.1Sms/Fgf3tm1.1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004145 abnormal muscle electrophysiology "anomaly in the function of the musculature as it relates to electrical phenomena" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyb5atm1Wolf/Cyb5atm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0004646 decreased cervical vertebrae number "reduced number of the seven bony segments of the spine located anterior to the thoracic vertebrae and caudal to the skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Entpd1tm1b(EUCOMM)Wtsi/Entpd1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Entpd1tm1b(EUCOMM)Wtsi/Ieg

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0005445 abnormal neurotransmitter release "aberration in the secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cyb5atm1Wolf/Cyb5atm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0005447 abnormal synaptic norepinephrine release "aberrant secretion across synapses of this widespread central and autonomic neurotransmitter, the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cyb5atm1Wolf/Cyb5atm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129X1/SvJ

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Fgf3tm1.1Sms/Fgf3tm1.1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

 MP:0006050 pulmonary fibrosis "formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf3tm1.1Sms/Fgf3tm1.1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006060 increased cerebral infarction size "increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129X1/SvJ

 MP:0008921 increased neurotransmitter release "increased production or release of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cyb5atm1Wolf/Cyb5atm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0008935 decreased mean platelet volume "reduced average content of platelet cells over normal" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Fgf3tm1.1Sms/Fgf3tm1.1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Entpd1tm1Djp/Entpd1tm1Djp
Genetic Background: B6.129-Entpd1tm1Djp

 MP:0011746 spleen fibrosis "invasion of fibrous connective tissue into the spleen, often resulting from inflammation or injury" [MGI:csmith]
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Allelic Composition: Fgf3tm1.1Sms/Fgf3tm1.1Sms
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000048120 Entpd1 / P55772 / Ectonucleoside triphosphate diphosphohydrolase 1 / P49961* / AL365273.2*  / complex






 

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