ENSMUSG00000074743


Mus musculus

Features
Gene ID: ENSMUSG00000074743
  
Biological name :Thbd
  
Synonyms : P15306 / Thbd / thrombomodulin
  
Possible biological names infered from orthology : P07204
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: G3
Gene start: 148404466
Gene end: 148408188
  
Corresponding Affymetrix probe sets: 10488378 (MoGene1.0st)   1448529_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096877
NCBI entrez gene - 21824     See in Manteia.
MGI - MGI:98736
RefSeq - NM_009378
RefSeq Peptide - NP_033404
swissprot - P15306
swissprot - Q543W3
Ensembl - ENSMUSG00000074743
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 thbdENSDARG00000092470Danio rerio
 THBDENSGALG00000044442Gallus gallus
 THBDENSG00000178726Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cd93 / O89103 / Complement component C1q receptor / Q9NPY3* / CD93 molecule*ENSMUSG0000002743527
Cd248 / Q91V98 / Endosialin / Q9HCU0* / CD248 molecule*ENSMUSG0000005648124
Q6NZL8 / Scube1 / signal peptide, CUB domain, EGF-like 1 / Q8IWY4* / signal peptide, CUB domain and EGF like domain containing 1*ENSMUSG0000001676321
Q66PY1 / Scube3 / Signal peptide, CUB and EGF-like domain-containing protein 3 / Q8IX30* / signal peptide, CUB domain and EGF like domain containing 3*ENSMUSG0000003867720
Q9JJS0 / Scube2 / Signal peptide, CUB and EGF-like domain-containing protein 2 / Q9NQ36* / signal peptide, CUB domain and EGF like domain containing 2*ENSMUSG0000000727918
Matn2 / O08746 / Mus musculus matrilin 2 (Matn2), transcript variant 1, mRNA. / O00339* / matrilin 2*ENSMUSG0000002232417
Q8VCP9 / Clec14a / C-type lectin domain family 14 member A / Q86T13* / C-type lectin domain containing 14A*ENSMUSG0000004593015
Matn4 / matrilin 4 / O95460*ENSMUSG0000001699512
Matn3 / O35701 / Matrilin-3 / O15232*ENSMUSG0000002058311
Matn1 / P51942 / Cartilage matrix protein / P21941* / matrilin 1, cartilage matrix protein*ENSMUSG000000405338
Vwa1 / Q8R2Z5 / von Willebrand factor A domain containing 1 / Q6PCB0*ENSMUSG000000421165


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001304  C-type lectin-like
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR015149  Thrombomodulin-like, EGF-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR016316  Thrombomodulin
 IPR018097  EGF-like calcium-binding, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007565 female pregnancy IMP
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0010165 response to X-ray IEA
 biological_processGO:0030195 negative regulation of blood coagulation IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0050819 negative regulation of coagulation TAS
 biological_processGO:0051591 response to cAMP IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005774 vacuolar membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016327 apicolateral plasma membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
Common Pathway of Fibrin Clot Formation
Cell surface interactions at the vascular wall


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: SfnEr/SfnEr
Genetic Background: involves: C57BL/6By

Allelic Composition: Thbdtm1Wlr/Thbdtm1Wlr
Genetic Background: B6.129S2-Thbdtm1Wlr

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Thbdtm1Rdr/Thbdtm1Rdr
Genetic Background: involves: 129S2/SvPas

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000465 gastrointestinal hemorrhage "bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: SfnEr/SfnEr
Genetic Background: involves: C57BL/6By

Allelic Composition: Thbdtm1Wlr/Thbdtm1Wlr
Genetic Background: B6.129S2-Thbdtm1Wlr

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Thbdtm1Wlr/Thbdtm2Rdr
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Thbdtm1Wlr/Thbdtm1Wlr
Genetic Background: B6.129S2-Thbdtm1Wlr

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Ndntm1Alb/Ndn+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001713 reduced trophoblast cell number "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171]
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Allelic Composition: Ndntm1Alb/Ndn+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Ndntm1Alb/Ndn+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Ndntm1Alb/Ndn+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Fgatm1Jld/Fgatm1Jld,Thbdtm2Rdr/Thbdtm2Rdr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Thbdtm1Rdr/Thbdtm1Rdr
Genetic Background: involves: 129S2/SvPas

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab,Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001916 intracerebral hemorrhage "bleeding within the cerebrum" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plattm1Mlg/Plattm1Mlg,Thbdtm2Rdr/Thbdtm2Rdr
Genetic Background: involves: 129S2/SvPas

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Thbdtm1Rdr/Thbdtm1Rdr
Genetic Background: involves: 129S2/SvPas

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Thbdtm1.1Hlwu/Thbdtm1.1Hlwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129-Thbdtm1.1Hlwu Lyz2tm1(cre)Ifo

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ncf4tm2Pth/Ncf4tm2Pth
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Thbdtm2Emc/Thbdtm2Emc
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Thbdtm1Wlr/Thbdtm2Rdr
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Thbdtm1Wlr/Thbdtm1Wlr
Genetic Background: B6.129S2-Thbdtm1Wlr

 MP:0002584 small ectoplacental cone 
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Allelic Composition: Ndntm1Alb/Ndn+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Fgatm1Jld/Fgatm1Jld,Thbdtm2Rdr/Thbdtm2Rdr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003037 increased infarction size "increased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Ncf4tm2Pth/Ncf4tm2Pth
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Ndntm1Alb/Ndn+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003415 priapism "prolonged penile erection, often painful and without sexual desire " [smb:Susan M Bello, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003548 pulmonary hypertension "sustained high pulmonary pressure at a level that is likely to result in disease and/or other pathological states" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:54986]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Ncf4tm2Pth/Ncf4tm2Pth
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003913 increased right ventricle weight "greater than average weight of the right ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003974 abnormal endocardium morphology "malformation of the thin serous membrane, primarily composed of endothelial tissue, that lines the interior of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Thbdtm1Rdr/Thbdtm1Rdr
Genetic Background: involves: 129S2/SvPas

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ndntm1Alb/Ndn+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Thbdtm1Wlr/Thbdtm2Rdr
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Thbdtm1Wlr/Thbdtm1Wlr
Genetic Background: B6.129S2-Thbdtm1Wlr

 MP:0005161 hematuria "presence of blood in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:78193]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Thbdtm1Wlr/Thbdtm1Wlr
Genetic Background: B6.129S2-Thbdtm1Wlr

Allelic Composition: Thbdtm1.1(THBD)Sltz/Thbdtm1.1(THBD)Sltz
Genetic Background: B6.129S(FVB)-Thbdtm1.1(THBD)Sltz

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Thbdtm1.1Hlwu/Thbdtm1.1Hlwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129-Thbdtm1.1Hlwu Lyz2tm1(cre)Ifo

 MP:0005243 hemothorax "bleeding into the pleural space" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mnx1tm3Tmj/Mnx1tm3Tmj
Genetic Background: involves: 129S1/Sv

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Zbtb46tm2.1Mnz/Zbtb46tm2.1Mnz
Genetic Background: involves: C57BL/6

Allelic Composition: Thbdtm1(THBD)Sltz/Thbdtm1(THBD)Sltz
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Thbdtm1(THBD)Sltz/Thbd+
Genetic Background: either: 129S/SvEv-Thbdtm1(THBD)Sltz or (involves: 129S/SvEv * C57BL/6)

Allelic Composition: Thbdtm1.1(THBD)Sltz/Thbdtm1.1(THBD)Sltz
Genetic Background: B6.129S(FVB)-Thbdtm1.1(THBD)Sltz

Allelic Composition: Thbdtm1.1(THBD)Sltz/Thbdtm1.1(THBD)Sltz
Genetic Background: 129S/SvEv(FVB)-Thbdtm1.1(THBD)Sltz

Allelic Composition: Thbdtm1.1(THBD)Sltz/Thbd+
Genetic Background: either: 129S/SvEv(FVB)-Thbdtm1.1(THBD)Sltz or B6.129S(FVB)-Thbdtm1.1(THBD)Sltz

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Thbdtm1.1(THBD)Sltz/Thbdtm1.1(THBD)Sltz
Genetic Background: B6.129(FVB)-Thbdtm1.1(THBD)Sltz Apoetm1Unc

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Ncf4tm2Pth/Ncf4tm2Pth
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Thbdtm1Wlr/Thbdtm1Wlr
Genetic Background: B6.129S2-Thbdtm1Wlr

Allelic Composition: Thbdtm1.1Hlwu/Thbdtm1.1Hlwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129-Thbdtm1.1Hlwu Lyz2tm1(cre)Ifo

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Thbdtm1.1Hlwu/Thbdtm1.1Hlwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129-Thbdtm1.1Hlwu Lyz2tm1(cre)Ifo

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Thbdtm1Wlr/Thbdtm1Wlr
Genetic Background: B6.129S2-Thbdtm1Wlr

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Thbdtm1.1Hlwu/Thbdtm1.1Hlwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129-Thbdtm1.1Hlwu Lyz2tm1(cre)Ifo

 MP:0008641 increased circulating interleukin-1 beta level "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Ncf4tm2Pth/Ncf4tm2Pth
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Thbdtm1Wlr/Thbdtm1Wlr
Genetic Background: B6.129S2-Thbdtm1Wlr

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ncf4tm2Pth/Ncf4tm2Pth
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Thbdtm1Wlr/Thbdtm1Wlr
Genetic Background: B6.129S2-Thbdtm1Wlr

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Thbdtm1Wlr/Thbdtm2Rdr
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Plattm1Mlg/Plattm1Mlg,Thbdtm2Rdr/Thbdtm2Rdr
Genetic Background: involves: 129S2/SvPas

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Thbdtm2Emc/Thbdtm2Emc
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Thbdtm1Wlr/Thbdtm1Wlr
Genetic Background: B6.129S2-Thbdtm1Wlr

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Thbdtm1.1Hlwu/Thbdtm1.1Hlwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129-Thbdtm1.1Hlwu Lyz2tm1(cre)Ifo

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Thbdtm1.1Hlwu/Thbdtm1.1Hlwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129-Thbdtm1.1Hlwu Lyz2tm1(cre)Ifo

 MP:0010211 abnormal acute phase protein level "deviation from the normal levels of the series of proteins found in the blood shortly after infection and which participate in the early phases of host defense against infection" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Ndntm1Alb/Ndn+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Ndntm1Alb/Ndn+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Fgatm1Jld/Fgatm1Jld,Thbdtm2Rdr/Thbdtm2Rdr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Thbdtm1Rdr/Thbdtm1Rdr
Genetic Background: involves: 129S2/SvPas

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Tardbptm1b(EUCOMM)Wtsi/Tardbptm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tardbptm1b(EUCOMM)Wtsi/H

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Zbtb46tm2.1Mnz/Zbtb46tm2.1Mnz
Genetic Background: involves: C57BL/6

Allelic Composition: Thbdtm1.1(THBD)Sltz/Thbdtm1.1(THBD)Sltz
Genetic Background: 129S/SvEv(FVB)-Thbdtm1.1(THBD)Sltz

 MP:0011112 partial lethality during fetal growth through weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Thbdtm1(THBD)Sltz/Thbdtm1(THBD)Sltz
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Thbdtm1.1(THBD)Sltz/Thbdtm1.1(THBD)Sltz
Genetic Background: B6.129S(FVB)-Thbdtm1.1(THBD)Sltz

 MP:0011514 skin hemorrhage "bleeding into the skin" [MGI:anna]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0012501 abnormal pericardial cavity morphology "any structural anomaly of the anatomical body cavity in which the heart lies; the pericardial cavity forms in the lateral plate mesoderm above the buccopharyngeal membrane, as part of the early intraembryonic coelom, and is initially continuous with the two early pleural cavities" [MGI:anna]
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Allelic Composition: Ndntm1Alb/Ndn+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Tardbptm1b(EUCOMM)Wtsi/Tardbptm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tardbptm1b(EUCOMM)Wtsi/H

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Tardbptm1b(EUCOMM)Wtsi/Tardbptm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Tardbptm1b(EUCOMM)Wtsi/H

 MP:0020407 abnormal placental thrombosis "any anomaly in the formation or presence of a thrombus within the blood vessel network of the placenta" [MGI:anna]
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Allelic Composition: Epas1tm1Fong/Epas1tm1Fong
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027249 F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*  / complex / reaction






 

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