ENSMUSG00000020583


Mus musculus

Features
Gene ID: ENSMUSG00000020583
  
Biological name :Matn3
  
Synonyms : Matn3 / Matrilin-3 / O35701
  
Possible biological names infered from orthology : O15232
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A1.1
Gene start: 8947929
Gene end: 8972028
  
Corresponding Affymetrix probe sets: 10394488 (MoGene1.0st)   1422148_at (Mouse Genome 430 2.0 Array)   1455948_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020899
NCBI entrez gene - 17182     See in Manteia.
MGI - MGI:1328350
RefSeq - NM_010770
RefSeq Peptide - NP_034900
swissprot - O35701
Ensembl - ENSMUSG00000020583
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 matn3aENSDARG00000069245Danio rerio
 matn3bENSDARG00000069265Danio rerio
 MATN3ENSGALG00000016478Gallus gallus
 MATN3ENSG00000132031Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Matn4 / matrilin 4 / O95460*ENSMUSG0000001699538
Matn2 / O08746 / Mus musculus matrilin 2 (Matn2), transcript variant 1, mRNA. / O00339* / matrilin 2*ENSMUSG0000002232438
Matn1 / P51942 / Cartilage matrix protein / P21941* / matrilin 1, cartilage matrix protein*ENSMUSG0000004053332
Vwa1 / Q8R2Z5 / von Willebrand factor A domain containing 1 / Q6PCB0*ENSMUSG0000004211618
Q66PY1 / Scube3 / Signal peptide, CUB and EGF-like domain-containing protein 3 / Q8IX30* / signal peptide, CUB domain and EGF like domain containing 3*ENSMUSG0000003867717
Q6NZL8 / Scube1 / signal peptide, CUB domain, EGF-like 1 / Q8IWY4* / signal peptide, CUB domain and EGF like domain containing 1*ENSMUSG0000001676316
Q9JJS0 / Scube2 / Signal peptide, CUB and EGF-like domain-containing protein 2 / Q9NQ36* / signal peptide, CUB domain and EGF like domain containing 2*ENSMUSG0000000727914
Cd93 / O89103 / Complement component C1q receptor / Q9NPY3* / CD93 molecule*ENSMUSG0000002743514
Thbd / P15306 / thrombomodulin / P07204*ENSMUSG0000007474314
Cd248 / Q91V98 / Endosialin / Q9HCU0* / CD248 molecule*ENSMUSG0000005648113
Q8VCP9 / Clec14a / C-type lectin domain family 14 member A / Q86T13* / C-type lectin domain containing 14A*ENSMUSG000000459306


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR002035  von Willebrand factor, type A
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR019466  Matrilin, coiled-coil trimerisation domain
 IPR026823  Complement Clr-like EGF domain
 IPR030765  Matrilin 3
 IPR036337  Matrilin, coiled-coil domain superfamily
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
ECM proteoglycans
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Foxp3tm1Ayr/Foxp3tm1Ayr,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Foxp3tm1Ayr/Foxp3tm1Ayr,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Matn3tm1Mbri/Matn3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
Show

Allelic Composition: Foxp3tm1Ayr/Foxp3tm1Ayr,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Foxp3tm1Ayr/Foxp3tm1Ayr,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxp3tm1Ayr/Foxp3tm1Ayr,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxp3tm1Ayr/Foxp3tm1Ayr,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Foxp3tm1Ayr/Foxp3tm1Ayr,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Matn3tm1Mbri/Matn3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003560 osteoarthritis "a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more joints" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95374]
Show

Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
Show

Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb

Allelic Composition: Matn3tm1Mbri/Matn3tm1Mbri
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Matn3tm1Mbri/Matn3tm1Mbri
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb

 MP:0014101 decreased chondrocyte proliferation "decreased amount of multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population" [GO:0035988]
Show

Allelic Composition: Matn3tm1Mbri/Matn3tm1Mbri
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0014103 increased chondrocyte apoptosis "increased number of chondrocytes undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Matn3tm1Mbri/Matn3tm1Mbri
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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