ENSDARG00000018111


Danio rerio

Features
Gene ID: ENSDARG00000018111
  
Biological name :kdm7aa
  
Synonyms : kdm7aa / lysine (K)-specific demethylase 7Aa / Q5RHD1
  
Possible biological names infered from orthology : 4921501E09Rik / Histone lysine demethylase PHF8 / PHD finger protein 8 / PHF8 / Q80TJ7 / Q9UPP1 / RIKEN cDNA 4921501E09 gene
  
Species: Danio rerio
  
Chr. number: 4
Strand: -1
Band:
Gene start: 22484830
Gene end: 22519525
  
Corresponding Affymetrix probe sets: Dr.18372.1.A1_at (Zebrafish Array)   Dr.18380.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000111845
Ensembl peptide - ENSDARP00000147148
Ensembl peptide - ENSDARP00000012964
Ensembl peptide - ENSDARP00000104491
NCBI entrez gene - 321248     See in Manteia.
RefSeq - NM_001346151
RefSeq Peptide - NP_001333080
swissprot - E7FCP4
swissprot - Q5RHD0
swissprot - Q5RHD1
ZFIN ID - ZDB-GENE-030131-9829
Ensembl - ENSDARG00000018111
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PHF8ENSG00000172943Homo sapiens
 4921501E09RikENSMUSG00000023350Mus musculus
 Phf8ENSMUSG00000041229Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
kdm7ab / lysine (K)-specific demethylase 7Ab / KDM7A* / Q3UWM4* / Q6ZMT4* / lysine demethylase 7A* / Lysine-specific demethylase 7A *ENSDARG0000001855966
phf8 / P0CH95 / PHD finger protein 8 / Q80TJ7* / Q9UPP1* / 4921501E09Rik* / RIKEN cDNA 4921501E09 gene* / Histone lysine demethylase PHF8 *ENSDARG0000000658452
phf2 / PHD finger protein 2 / O75151* / Q9WTU0* / Lysine-specific demethylase PHF2 *ENSDARG0000001869150
kdm2ab / lysine (K)-specific demethylase 2Ab / KDM2A* / Q9Y2K7* / lysine demethylase 2A*ENSDARG0000007813322
kdm2aa / lysine (K)-specific demethylase 2Aa / KDM2A* / Q9Y2K7* / lysine demethylase 2A*ENSDARG0000005965321
kdm2bb / lysine (K)-specific demethylase 2Bb / KDM2B* / Q6P1G2* / Q8NHM5* / lysine demethylase 2B* / Lysine-specific demethylase 2B *ENSDARG0000004601018
kdm2ba / lysine (K)-specific demethylase 2BaENSDARG000000365931
btr30 / FBXL19 / zgc:158376 / Q6PCT2* / F-box and leucine rich repeat protein 19*ENSDARG000001033620


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR003347  JmjC domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0030901 midbrain development IMP
 biological_processGO:0033169 histone H3-K9 demethylation IDA
 biological_processGO:0035574 histone H4-K20 demethylation ISS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070544 histone H3-K36 demethylation ISS
 biological_processGO:0071557 histone H3-K27 demethylation IDA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors ISS
 molecular_functionGO:0032454 histone demethylase activity (H3-K9 specific) IDA
 molecular_functionGO:0035575 histone demethylase activity (H4-K20 specific) ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0051864 histone demethylase activity (H3-K36 specific) ISS
 molecular_functionGO:0071558 histone demethylase activity (H3-K27 specific) IDA


Pathways (from Reactome)
Pathway description
Condensation of Prophase Chromosomes
HDMs demethylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000104114 kmt5ab / lysine methyltransferase 5Ab / KMT5A* / Q9NQR1* / lysine methyltransferase 5A*  / reaction
 ENSDARG00000105231 kmt5aa / lysine methyltransferase 5Aa / KMT5A* / Q9NQR1* / lysine methyltransferase 5A*  / reaction






 

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