ENSDARG00000019717


Danio rerio

Features
Gene ID: ENSDARG00000019717
  
Biological name :pbx2
  
Synonyms : pbx2 / pre-B-cell leukemia homeobox 2
  
Possible biological names infered from orthology : O35984 / P40425 / PBX homeobox 2
  
Species: Danio rerio
  
Chr. number: 16
Strand: 1
Band:
Gene start: 48616220
Gene end: 48643191
  
Corresponding Affymetrix probe sets: Dr.3010.1.S1_at (Zebrafish Array)   NM_131612_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000018156
Ensembl peptide - ENSDARP00000105703
Ensembl peptide - ENSDARP00000127644
Ensembl peptide - ENSDARP00000129676
NCBI entrez gene - 58136     See in Manteia.
RefSeq - NM_131612
RefSeq Peptide - NP_571687
swissprot - Q9I9B4
swissprot - X1WBQ2
swissprot - X1WHG4
ZFIN ID - ZDB-GENE-000405-5
Ensembl - ENSDARG00000019717
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PBX2ENSG00000204304Homo sapiens
 Pbx2ENSMUSG00000034673Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pbx1a / pre-B-cell leukemia homeobox 1a / PBX1* / P41778* / P40424* / PBX homeobox 1* / Pre-B-cell leukemia transcription factor 1 *ENSDARG0000010049467
pbx1b / pre-B-cell leukemia homeobox 1b / PBX1* / P40424* / PBX homeobox 1*ENSDARG0000010113167
pbx3a / pre-B-cell leukemia homeobox 3a / PBX3* / P40426* / O35317* / PBX homeobox 3* / Pre-B-cell leukemia transcription factor 3 *ENSDARG0000008926266
pbx3b / pre-B-cell leukemia homeobox 3b / PBX3* / P40426* / O35317* / PBX homeobox 3* / Pre-B-cell leukemia transcription factor 3 *ENSDARG0000001361563
pbx4 / pre-B-cell leukemia transcription factor 4 / Q99NE9* / Q9BYU1* / PBX homeobox 4* / Mus musculus pre B cell leukemia homeobox 4 (Pbx4), transcript variant 4, mRNA.*ENSDARG0000005215061


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR005542  PBX
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003007 heart morphogenesis IGI
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0030901 midbrain development IGI
 biological_processGO:0048741 skeletal muscle fiber development IGI
 biological_processGO:0055007 cardiac muscle cell differentiation IGI
 biological_processGO:0060059 embryonic retina morphogenesis in camera-type eye IGI
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood accumulation atrium , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle shape , abnormal
cardiac ventricle decreased size , abnormal
Show

 ZFA:0000028 heart primordium heart primordium unfused from heart primordium , abnormal
heart primordium myocardial precursor decreased amount , abnormal
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 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary malformed , abnormal
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 ZFA:0000046 retinal neural layer retinal neural layer lacks all parts of type retinal photoreceptor layer ventral region, abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000100 cerebellum cerebellum malformed , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000114 heart heart morphology , abnormal
heart decreased functionality , abnormal
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 ZFA:0000143 retinal photoreceptor layer retinal photoreceptor layer disorganized , abnormal
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 ZFA:0000152 retina retina morphology , abnormal
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 ZFA:0000360 heart tube heart tube aplastic , abnormal
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 ZFA:0000445 optic tectum optic tectum decreased size , abnormal
optic tectum disorganized , abnormal
Show

 ZFA:0000471 atrium atrium shape , abnormal
atrium decreased size , abnormal
Show

 ZFA:0000570 optic primordium optic primordium morphology , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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