ENSDARG00000037060


Danio rerio

Features
Gene ID: ENSDARG00000037060
  
Biological name :kmt2d
  
Synonyms : kmt2d / lysine (K)-specific methyltransferase 2D
  
Possible biological names infered from orthology : Histone-lysine N-methyltransferase 2D / lysine methyltransferase 2D / O14686 / Q6PDK2
  
Species: Danio rerio
  
Chr. number: 23
Strand: 1
Band:
Gene start: 27756984
Gene end: 27793877
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000119354
Ensembl peptide - ENSDARP00000121042
Ensembl peptide - ENSDARP00000053862
Ensembl peptide - ENSDARP00000116027
Ensembl peptide - ENSDARP00000119206
swissprot - E7F2F7
swissprot - E9QF90
swissprot - F1R3T7
swissprot - F1R733
swissprot - F1R7I1
ZFIN ID - ZDB-GENE-060223-2
Ensembl - ENSDARG00000037060
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000035501Gallus gallus
 ENSGALG00000031702Gallus gallus
 KMT2DENSG00000167548Homo sapiens
 Kmt2dENSMUSG00000048154Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
kmt2ca / lysine (K)-specific methyltransferase 2Ca / KMT2C* / Q8NEZ4* / lysine methyltransferase 2C*ENSDARG0000007931228
kmt2cb / lysine (K)-specific methyltransferase 2Cb / KMT2C* / Q8NEZ4* / lysine methyltransferase 2C*ENSDARG0000007556027
kmt2bb / lysine (K)-specific methyltransferase 2Bb / KMT2B* / O08550* / Q9UMN6* / lysine methyltransferase 2B* / Histone-lysine N-methyltransferase 2B *ENSDARG000000606977
kmt2a / lysine (K)-specific methyltransferase 2A / P55200* / Q03164* / lysine methyltransferase 2A* / Mus musculus lysine (K)-specific methyltransferase 2A (Kmt2a), transcript variant 1, mRNA.*ENSDARG000000045377
setd1a / SET domain containing 1A / O15047* / AC149222.1*ENSDARG000000600306
setd1ba / SET domain containing 1B, a / Q9UPS6* / SETD1B* / Q8CFT2* / SET domain containing 1B* / Histone-lysine N-methyltransferase SETD1B *ENSDARG000000608476
kmt2ba / lysine (K)-specific methyltransferase 2Ba / KMT2B* / O08550* / Q9UMN6* / lysine methyltransferase 2B* / Histone-lysine N-methyltransferase 2B *ENSDARG000000629626
setd1bb / SET domain containing 1B, bENSDARG000000772442


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR001841  Zinc finger, RING-type
 IPR001965  Zinc finger, PHD-type
 IPR003616  Post-SET domain
 IPR003888  FY-rich, N-terminal
 IPR003889  FY-rich, C-terminal
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019787  Zinc finger, PHD-finger
 IPR034732  Extended PHD (ePHD) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003428 chondrocyte intercalation involved in growth plate cartilage morphogenesis IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0051568 histone H3-K4 methylation IEA
 biological_processGO:0060026 convergent extension IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0035097 histone methyltransferase complex IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0042800 histone methyltransferase activity (H3-K4 specific) IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain decreased size , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle orientation atrium , abnormal
Show

 ZFA:0000029 hindbrain hindbrain decreased size , abnormal
Show

 ZFA:0000032 hypothalamus hypothalamus decreased thickness , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000109 forebrain forebrain nucleus elongated , abnormal
forebrain neuron differentiation decreased process quality , abnormal
Show

 ZFA:0000128 midbrain midbrain nucleus elongated , abnormal
midbrain neuron differentiation decreased process quality , abnormal
Show

 ZFA:0000135 notochord notochord increased width , abnormal
Show

 ZFA:0000160 tegmentum tegmentum decreased thickness , abnormal
Show

 ZFA:0000445 optic tectum optic tectum decreased thickness , abnormal
Show

 ZFA:0000545 medulla oblongata medulla oblongata decreased thickness , abnormal
Show

 ZFA:0001094 whole organism whole organism anterior-posterior axis shortened , abnormal
Show

 ZFA:0001114 head head lacks all parts of type cleithrum , abnormal
head lacks all parts of type opercle , abnormal
head lacks all parts of type Meckels cartilage , abnormal
head lacks all parts of type ceratohyal cartilage , abnormal
head lacks all parts of type pharyngeal arch 3-7 , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage decreased distance ceratohyal cartilage , abnormal
Show

 ZFA:0001321 neurocranial trabecula neurocranial trabecula truncated , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage increased width , abnormal
ceratohyal cartilage kinked , abnormal
ceratohyal cartilage shortened , abnormal
ceratohyal cartilage chondrocyte disorganized , abnormal
Show

 ZFA:0001405 ethmoid cartilage ethmoid cartilage truncated , abnormal
Show

 ZFA:0009084 chondrocyte chondrocyte filamentous actin position , abnormal
chondrocyte myosin II filament position , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr