Manteia

ENSDARG00000052769

Danio rerio

Features

Gene ID:	ENSDARG00000052769

Biological name :	glrbb

Synonyms :	glrbb / glycine receptor, beta b

Possible biological names infered from orthology :	GLRB / glycine receptor beta / Glycine receptor subunit beta / P48167 / P48168

Species:	Danio rerio

Chr. number:	14
Strand:	1
Band:
Gene start:	35691889
Gene end:	35732221

Corresponding Affymetrix probe sets:

Cross references:	Ensembl peptide - ENSDARP00000069171 NCBI entrez gene - 445193 See in Manteia. RefSeq - XM_021481003 RefSeq - NM_001003587 RefSeq Peptide - NP_001003587 swissprot - Q6DC22 ZFIN ID - ZDB-GENE-040801-106 Ensembl - ENSDARG00000052769

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
GLRB	ENSGALG00000009395	Gallus gallus
GLRB	ENSG00000109738	Homo sapiens
Glrb	ENSMUSG00000028020	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
glrba / glycine receptor, beta a / GLRB* / P48167* / P48168* / glycine receptor beta* / Glycine receptor subunit beta *	ENSDARG00000052782	86
glra4b / glycine receptor, alpha 4b / GLRA4* / Q5JXX5* / Q61603* / glycine receptor alpha 4* / Glycine receptor subunit alpha-4 *	ENSDARG00000058103	44
glra4a / glycine receptor, alpha 4a / GLRA4* / Q5JXX5* / Q61603* / glycine receptor alpha 4* / Glycine receptor subunit alpha-4 *	ENSDARG00000006865	44
glra2 / si:ch211-12n8.3	ENSDARG00000075012	43
glra3 / glycine receptor, alpha 3	ENSDARG00000011066	43
glra1 / O93430 / glycine receptor, alpha 1 / Q64018* / P23415* / Glycine receptor subunit alpha-1 *	ENSDARG00000012019	40
gabrb1 / gamma-aminobutyric acid (GABA) A receptor, beta 1 / P18505* / P50571* / Gamma-aminobutyric acid receptor subunit beta-1 * / gamma-aminobutyric acid type A receptor beta1 subunit*	ENSDARG00000076127	31
gabrb4 / gamma-aminobutyric acid (GABA) A receptor, beta 4 / GABRQ* / Q9UN88* / Q9JLF1* / Gamma-aminobutyric acid receptor subunit theta * / gamma-aminobutyric acid type A receptor theta subunit*	ENSDARG00000099096	30
gabrr2b / gamma-aminobutyric acid (GABA) A receptor, rho 2b / P56476* / GABRR2* / P28476* / Gamma-aminobutyric acid receptor subunit rho-2 * / gamma-aminobutyric acid type A receptor rho2 subunit*	ENSDARG00000014057	29
GABRB2 (1 of many) / gamma-aminobutyric acid type A receptor beta2 subunit / GABRB2* / P47870*	ENSDARG00000100032	28
FO704905.1 / GABRR1* / P24046* / gamma-aminobutyric acid type A receptor rho1 subunit*	ENSDARG00000098081	28
gabrb3 / gamma-aminobutyric acid (GABA) A receptor, beta 3	ENSDARG00000023771	28
gabrr1 / gamma-aminobutyric acid (GABA) A receptor, rho 1 / P24046* / P56475* / Gamma-aminobutyric acid receptor subunit rho-1 * / gamma-aminobutyric acid type A receptor rho1 subunit*	ENSDARG00000043902	27
gabrp / gamma-aminobutyric acid (GABA) A receptor, pi	ENSDARG00000020901	27
gabrd / gamma-aminobutyric acid (GABA) A receptor, delta / O14764* / P22933* / Gamma-aminobutyric acid receptor subunit delta * / gamma-aminobutyric acid type A receptor delta subunit*	ENSDARG00000059763	27
gabrr3a / gamma-aminobutyric acid (GABA) A receptor, rho 3a / A8MPY1* / GABRR3* / gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene)*	ENSDARG00000027153	27
gabrr3b / gamma-aminobutyric acid (GABA) A receptor, rho 3b / A8MPY1* / GABRR3* / gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene)*	ENSDARG00000030750	27
AL929217.1 / GABRP* / O00591* / gamma-aminobutyric acid type A receptor pi subunit*	ENSDARG00000059891	26
gabrz / gamma-aminobutyric acid (GABA) A receptor, zeta	ENSDARG00000094512	26
gabrb2 / gamma-aminobutyric acid (GABA) A receptor, beta 2 / P47870* / P63137* / Gamma-aminobutyric acid receptor subunit beta-2 * / gamma-aminobutyric acid type A receptor beta2 subunit*	ENSDARG00000079586	25

Protein motifs (from Interpro)

Interpro ID	Name
IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
IPR006201	Neurotransmitter-gated ion-channel
IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain
IPR008060	Glycine receptor beta
IPR018000	Neurotransmitter-gated ion-channel, conserved site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006811	ion transport	IEA
biological_process	GO:0006821	chloride transport	IEA
biological_process	GO:0007218	neuropeptide signaling pathway	IBA
biological_process	GO:0034220	ion transmembrane transport	IEA
biological_process	GO:0034613	cellular protein localization	IMP
biological_process	GO:0043200	response to amino acid	IBA
biological_process	GO:0060012	synaptic transmission, glycinergic	IBA
biological_process	GO:0060079	excitatory postsynaptic potential	IEA
biological_process	GO:1902476	chloride transmembrane transport	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0045211	postsynaptic membrane	IEA
molecular_function	GO:0004888	transmembrane signaling receptor activity	IEA
molecular_function	GO:0005216	ion channel activity	IEA
molecular_function	GO:0005230	extracellular ligand-gated ion channel activity	IEA
molecular_function	GO:0016594	glycine binding	IBA
molecular_function	GO:0016934	extracellularly glycine-gated chloride channel activity	IEA

Pathways (from Reactome)

Pathway description

Neurotransmitter receptors and postsynaptic signal transmission

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0000135	notochord	notochord degenerate , abnormal notochord undulate , abnormal notochord morphology , abnormal notochord quality , abnormal	Show
ZFA:0000473	trunk musculature	trunk musculature contractility , abnormal	Show
ZFA:0001094	whole organism	whole organism lethal (sensu genetics) , abnormal whole organism viability , abnormal whole organism movement behavioral quality , abnormal whole organism decreased length , abnormal whole organism axis shortened , abnormal	Show
ZFA:0001115	trunk	trunk slow muscle cell disorganized , abnormal	Show

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSDARG00000012019	glra1 / O93430 / glycine receptor, alpha 1 / Q64018* / P23415* / Glycine receptor subunit alpha-1 *	/ complex

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr