Manteia

ENSDARG00000012019

Danio rerio

Features

Gene ID:	ENSDARG00000012019

Biological name :	glra1

Synonyms :	glra1 / glycine receptor, alpha 1 / O93430

Possible biological names infered from orthology :	Glycine receptor subunit alpha-1 / P23415 / Q64018

Species:	Danio rerio

Chr. number:	14
Strand:	1
Band:
Gene start:	25816874
Gene end:	25911567

Corresponding Affymetrix probe sets:	Dr.620.1.S1_at (Zebrafish Array)

Cross references:	Ensembl peptide - ENSDARP00000003268 Ensembl peptide - ENSDARP00000116295 Ensembl peptide - ENSDARP00000047679 NCBI entrez gene - 30676 See in Manteia. swissprot - E9QC31 swissprot - B3DHZ5 swissprot - G1K2K7 swissprot - O93430 ZFIN ID - ZDB-GENE-991117-1 Ensembl - ENSDARG00000012019

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
GLRA1	ENSGALG00000004134	Gallus gallus
GLRA1	ENSG00000145888	Homo sapiens
Glra1	ENSMUSG00000000263	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
glra3 / glycine receptor, alpha 3	ENSDARG00000011066	76
glra4a / glycine receptor, alpha 4a / GLRA4* / Q5JXX5* / Q61603* / glycine receptor alpha 4* / Glycine receptor subunit alpha-4 *	ENSDARG00000006865	72
glra2 / si:ch211-12n8.3	ENSDARG00000075012	71
glra4b / glycine receptor, alpha 4b / GLRA4* / Q5JXX5* / Q61603* / glycine receptor alpha 4* / Glycine receptor subunit alpha-4 *	ENSDARG00000058103	69
glrba / glycine receptor, beta a / GLRB* / P48167* / P48168* / glycine receptor beta* / Glycine receptor subunit beta *	ENSDARG00000052782	43
glrbb / glycine receptor, beta b / GLRB* / P48167* / P48168* / glycine receptor beta* / Glycine receptor subunit beta *	ENSDARG00000052769	43
gabrb4 / gamma-aminobutyric acid (GABA) A receptor, beta 4 / GABRQ* / Q9UN88* / Q9JLF1* / Gamma-aminobutyric acid receptor subunit theta * / gamma-aminobutyric acid type A receptor theta subunit*	ENSDARG00000099096	35
gabrb1 / gamma-aminobutyric acid (GABA) A receptor, beta 1 / P18505* / P50571* / Gamma-aminobutyric acid receptor subunit beta-1 * / gamma-aminobutyric acid type A receptor beta1 subunit*	ENSDARG00000076127	35
gabrb3 / gamma-aminobutyric acid (GABA) A receptor, beta 3	ENSDARG00000023771	34
gabrd / gamma-aminobutyric acid (GABA) A receptor, delta / O14764* / P22933* / Gamma-aminobutyric acid receptor subunit delta * / gamma-aminobutyric acid type A receptor delta subunit*	ENSDARG00000059763	32
GABRB2 (1 of many) / gamma-aminobutyric acid type A receptor beta2 subunit / GABRB2* / P47870*	ENSDARG00000100032	32
gabrp / gamma-aminobutyric acid (GABA) A receptor, pi	ENSDARG00000020901	31
FO704905.1 / GABRR1* / P24046* / gamma-aminobutyric acid type A receptor rho1 subunit*	ENSDARG00000098081	31
gabrz / gamma-aminobutyric acid (GABA) A receptor, zeta	ENSDARG00000094512	31
AL929217.1 / GABRP* / O00591* / gamma-aminobutyric acid type A receptor pi subunit*	ENSDARG00000059891	31
gabrr1 / gamma-aminobutyric acid (GABA) A receptor, rho 1 / P24046* / P56475* / Gamma-aminobutyric acid receptor subunit rho-1 * / gamma-aminobutyric acid type A receptor rho1 subunit*	ENSDARG00000043902	30
gabrr3b / gamma-aminobutyric acid (GABA) A receptor, rho 3b / A8MPY1* / GABRR3* / gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene)*	ENSDARG00000030750	30
gabrr3a / gamma-aminobutyric acid (GABA) A receptor, rho 3a / A8MPY1* / GABRR3* / gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene)*	ENSDARG00000027153	30
gabrr2b / gamma-aminobutyric acid (GABA) A receptor, rho 2b / P56476* / GABRR2* / P28476* / Gamma-aminobutyric acid receptor subunit rho-2 * / gamma-aminobutyric acid type A receptor rho2 subunit*	ENSDARG00000014057	30
gabrb2 / gamma-aminobutyric acid (GABA) A receptor, beta 2 / P47870* / P63137* / Gamma-aminobutyric acid receptor subunit beta-2 * / gamma-aminobutyric acid type A receptor beta2 subunit*	ENSDARG00000079586	30

Protein motifs (from Interpro)

Interpro ID	Name
IPR006028	Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
IPR006201	Neurotransmitter-gated ion-channel
IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain
IPR008127	Glycine receptor alpha
IPR008128	Glycine receptor alpha1
IPR018000	Neurotransmitter-gated ion-channel, conserved site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006811	ion transport	IDA
biological_process	GO:0006821	chloride transport	IEA
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007218	neuropeptide signaling pathway	IBA
biological_process	GO:0007417	central nervous system development	IMP
biological_process	GO:0034220	ion transmembrane transport	IEA
biological_process	GO:0043200	response to amino acid	IDA
biological_process	GO:0045664	regulation of neuron differentiation	IMP
biological_process	GO:0051260	protein homooligomerization	IDA
biological_process	GO:0060012	synaptic transmission, glycinergic	IBA
biological_process	GO:0060079	excitatory postsynaptic potential	IEA
biological_process	GO:0071230	cellular response to amino acid stimulus	ISS
biological_process	GO:0071294	cellular response to zinc ion	ISS
biological_process	GO:0071361	cellular response to ethanol	ISS
biological_process	GO:1902476	chloride transmembrane transport	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0005887	integral component of plasma membrane	ISS
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IDA
cellular_component	GO:0030054	cell junction	IEA
cellular_component	GO:0030425	dendrite	IEA
cellular_component	GO:0034707	chloride channel complex	IEA
cellular_component	GO:0042995	cell projection	IEA
cellular_component	GO:0043204	perikaryon	IEA
cellular_component	GO:0045202	synapse	IEA
cellular_component	GO:0045211	postsynaptic membrane	IEA
molecular_function	GO:0004888	transmembrane signaling receptor activity	IEA
molecular_function	GO:0005216	ion channel activity	IEA
molecular_function	GO:0005230	extracellular ligand-gated ion channel activity	IEA
molecular_function	GO:0005254	chloride channel activity	IEA
molecular_function	GO:0008270	zinc ion binding	ISS
molecular_function	GO:0016594	glycine binding	IDA
molecular_function	GO:0016934	extracellularly glycine-gated chloride channel activity	IEA
molecular_function	GO:0022824	transmitter-gated ion channel activity	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

Neurotransmitter receptors and postsynaptic signal transmission

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSDARG00000052769	glrbb / glycine receptor, beta b / GLRB* / P48167* / P48168* / glycine receptor beta* / Glycine receptor subunit beta *	/ complex
ENSDARG00000052782	glrba / glycine receptor, beta a / GLRB* / P48167* / P48168* / glycine receptor beta* / Glycine receptor subunit beta *	/ complex

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr