ENSDARG00000098272


Danio rerio

Features
Gene ID: ENSDARG00000098272
  
Biological name :nipbla
  
Synonyms : nipbla / nipped-B homolog a (Drosophila)
  
Possible biological names infered from orthology : NIPBL / NIPBL, cohesin loading factor / Nipped-B-like protein / Q6KC79 / Q6KCD5
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 8005911
Gene end: 8096232
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000132739
NCBI entrez gene - 570900     See in Manteia.
RefSeq - NM_001246284
RefSeq Peptide - NP_001233213
swissprot - A0A0R4IGM2
ZFIN ID - ZDB-GENE-060526-121
Ensembl - ENSDARG00000098272
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000003605Gallus gallus
 NIPBLLENSGALG00000039023Gallus gallus
 NIPBLENSG00000164190Homo sapiens
 NipblENSMUSG00000022141Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
F1QBY1 / nipblb / nipped-B homolog b (Drosophila) / NIPBL* / Q6KCD5* / Q6KC79* / Nipped-B-like protein * / NIPBL, cohesin loading factor*ENSDARG0000006105270


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR024986  Sister chromatid cohesion C-terminal domain
 IPR026003  HEAT repeat associated with sister chromatid cohesion protein
 IPR033031  SCC2/Nipped-B family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010468 regulation of gene expression IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003682 chromatin binding IEA


Pathways (from Reactome)
Pathway description
Cohesin Loading onto Chromatin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000085 apical ectodermal ridge pectoral fin bud apical ectodermal ridge pectoral fin bud embryonic pectoral fin morphogenesis decreased process quality , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
eye decreased size , ameliorated
Show

 ZFA:0000112 gut gut absent , abnormal
gut decreased thickness , abnormal
gut malformed , abnormal
Show

 ZFA:0000114 heart heart edematous , abnormal
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 ZFA:0000141 pectoral fin bud pectoral fin bud physical object quality , abnormal
pectoral fin bud regulation of smoothened signaling pathway process quality , abnormal
pectoral fin bud embryonic pectoral fin morphogenesis decreased process quality , abnormal
pectoral fin bud decreased size , abnormal
Show

 ZFA:0000257 pectoral fin cartilage pectoral fin cartilage malformed , abnormal
Show

 ZFA:0000330 cloacal chamber cloacal chamber non-functional , abnormal
Show

 ZFA:0000360 heart tube heart tube aplastic , abnormal
heart tube bifurcated , abnormal
Show

 ZFA:0001094 whole organism whole organism endodermal cell decreased amount , abnormal
whole organism decreased length , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism lethal (sensu genetics) , ameliorated
Show

 ZFA:0001114 head head decreased size , abnormal
head decreased size , ameliorated
head apoptotic process increased occurrence , abnormal
head apoptotic process increased occurrence , ameliorated
Show

 ZFA:0001115 trunk trunk decreased length , ameliorated
Show

 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
post-vent region branched , abnormal
post-vent region curved , abnormal
post-vent region curved , ameliorated
post-vent region apoptotic process increased occurrence , abnormal
post-vent region apoptotic process increased occurrence , ameliorated
Show

 ZFA:0001161 pectoral fin pectoral fin decreased length , abnormal
Show

 ZFA:0001422 hyosymplectic cartilage hyosymplectic cartilage decreased amount , abnormal
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 ZFA:0001456 pectoral fin endoskeletal disc pectoral fin endoskeletal disc chondrocyte disorganized , abnormal
Show

 ZFA:0001458 cranial cartilage cranial cartilage cartilage development disrupted , abnormal
cranial cartilage cartilage development decreased process quality , ameliorated
Show

 ZFA:0005316 fin fold pectoral fin bud fin fold pectoral fin bud embryonic pectoral fin morphogenesis decreased process quality , abnormal
Show

 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte increased accumulation intermediate cell mass of mesoderm , abnormal
nucleate erythrocyte increased accumulation yolk anatomical surface, abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000044144 wapla / WAPL cohesin release factor a / WAPL* / Q7Z5K2* / Q65Z40* / WAPL cohesin release factor*  / reaction / complex
 ENSDARG00000061052 F1QBY1 / nipblb / nipped-B homolog b (Drosophila) / NIPBL* / Q6KCD5* / Q6KC79* / Nipped-B-like protein * / NIPBL, cohesin loading factor*  / reaction
 ENSDARG00000055022 pds5a / PDS5 cohesin associated factor A / Q29RF7*  / reaction / complex
 ENSDARG00000098272 nipbla / nipped-B homolog a (Drosophila) / NIPBL* / Q6KC79* / Q6KCD5* / Nipped-B-like protein * / NIPBL, cohesin loading factor*  / reaction
 ENSDARG00000098897 pds5b / PDS5 cohesin associated factor B / Q4VA53* / Q9NTI5* / Mus musculus PDS5 cohesin associated factor B (Pds5b), transcript variant 2, mRNA.*  / complex / reaction






 

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