ENSDARG00000104735


Danio rerio

Features
Gene ID: ENSDARG00000104735
  
Biological name :nkx6.2
  
Synonyms : NK6 homeobox 2 / nkx6.2
  
Possible biological names infered from orthology : Q9C056
  
Species: Danio rerio
  
Chr. number: 13
Strand: 1
Band:
Gene start: 51579851
Gene end: 51584264
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000140556
NCBI entrez gene - 565782     See in Manteia.
swissprot - A0A0R4IY89
ZFIN ID - ZDB-GENE-070626-1
Ensembl - ENSDARG00000104735
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NKX6-2ENSGALG00000010500Gallus gallus
 NKX6-2ENSG00000148826Homo sapiens
 Nkx6-2ENSMUSG00000041309Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nkx6.1 / NK6 homeobox 1 / P78426* / Q99MA9* / Homeobox protein Nkx-6.1 *ENSDARG0000002256968
nkx6.3 / NK6 homeobox 3 / A6NJ46* / Q3UHX8* / Homeobox protein Nkx-6.3 *ENSDARG0000006052947
barhl2 / BarH-like homeobox 2 / Q8VIB5* / Q9NY43* / BarH-like 2 homeobox protein *ENSDARG0000010436120
dbx1a / Q9PTU1 / developing brain homeobox 1a / DBX1* / A6NMT0* / P52950* / Homeobox protein DBX1 * / developing brain homeobox 1*ENSDARG0000008639320
hlx1 / H2.0-like homeo box 1 (Drosophila) / HLX* / Q14774* / Q61670* / H2.0 like homeobox* / H2.0-like homeobox protein *ENSDARG0000000913420
barhl1b / BarH-like homeobox 1b / Q9BZE3* / P63157* / BARHL1* / BarH like homeobox 1* / BarH-like 1 homeobox protein *ENSDARG0000001901319
tlx3b / T cell leukemia homeobox 3bENSDARG0000001761519
dbx1b / developing brain homeobox 1b / DBX1* / P52950* / A6NMT0* / Homeobox protein DBX1 * / developing brain homeobox 1*ENSDARG0000000185918
tlx1 / T cell leukemia homeobox 1 / P31314*ENSDARG0000000396518
tlx2 / T cell leukemia homeobox 2 / TLX1* / P31314* / T cell leukemia homeobox 1*ENSDARG0000001127318
barx2 / BARX homeobox 2 / O08686* / Q9UMQ3* / Homeobox protein BarH-like 2 *ENSDARG0000004109818
barhl1a / BarH-like homeobox 1a / Q9BZE3* / P63157* / BARHL1* / BarH like homeobox 1* / BarH-like 1 homeobox protein *ENSDARG0000003550817
bsx / Q6R3Q6 / brain-specific homeobox / Q3C1V8* / Q810B3* / Brain-specific homeobox protein homolog *ENSDARG0000006897617
lbx1a / ladybird homeobox 1a / LBX1* / P52954* / P52955* / ladybird homeobox 1* / Transcription factor LBX1 *ENSDARG0000001832116
barx1 / BARX homeobox 1 / Q9ER42* / Q9HBU1* / Homeobox protein BarH-like 1 *ENSDARG0000000740716
lbx2 / ladybird homeobox 2ENSDARG0000002513116
HHEX / hematopoietically expressed homeobox / Q03014*ENSDARG0000009823115
lbx1b / ladybird homeobox 1b / LBX1* / P52954* / P52955* / ladybird homeobox 1* / Transcription factor LBX1 *ENSDARG0000001861113


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003309 type B pancreatic cell differentiation IMP
 biological_processGO:0003310 pancreatic A cell differentiation IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0021522 spinal cord motor neuron differentiation IMP
 biological_processGO:0031018 endocrine pancreas development IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000254 pancreas primordium pancreas primordium has fewer parts of type endocrine cell , abnormal
Show

 ZFA:0001390 pancreatic bud pancreatic bud has fewer parts of type endocrine cell , abnormal
pancreatic bud has fewer parts of type pancreatic A cell , abnormal
pancreatic bud lacks parts or has fewer parts of type pancreatic A cell , abnormal
pancreatic bud has fewer parts of type pancreatic B cell , abnormal
Show

 ZFA:0009244 primary motor neuron primary motor neuron axon branched , abnormal
primary motor neuron axon decreased length , abnormal
primary motor neuron axon decreased amount , abnormal
primary motor neuron axon structure , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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