ENSDARG00000022569


Danio rerio

Features
Gene ID: ENSDARG00000022569
  
Biological name :nkx6.1
  
Synonyms : NK6 homeobox 1 / nkx6.1
  
Possible biological names infered from orthology : Homeobox protein Nkx-6.1 / P78426 / Q99MA9
  
Species: Danio rerio
  
Chr. number: 21
Strand: 1
Band:
Gene start: 19070921
Gene end: 19073831
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000035373
NCBI entrez gene - 436748     See in Manteia.
RefSeq - NM_001002475
RefSeq Peptide - NP_001002475
swissprot - F1QUC3
ZFIN ID - ZDB-GENE-040718-178
Ensembl - ENSDARG00000022569
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NKX6-1ENSGALG00000032545Gallus gallus
 NKX6-1ENSG00000163623Homo sapiens
 Nkx6-1ENSMUSG00000035187Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nkx6.2 / NK6 homeobox 2 / Q9C056*ENSDARG0000010473561
nkx6.3 / NK6 homeobox 3 / A6NJ46* / Q3UHX8* / Homeobox protein Nkx-6.3 *ENSDARG0000006052939
tlx2 / T cell leukemia homeobox 2 / TLX1* / P31314* / T cell leukemia homeobox 1*ENSDARG0000001127320
tlx3b / T cell leukemia homeobox 3bENSDARG0000001761519
barhl2 / BarH-like homeobox 2 / Q8VIB5* / Q9NY43* / BarH-like 2 homeobox protein *ENSDARG0000010436119
hlx1 / H2.0-like homeo box 1 (Drosophila) / HLX* / Q14774* / Q61670* / H2.0 like homeobox* / H2.0-like homeobox protein *ENSDARG0000000913419
barhl1b / BarH-like homeobox 1b / Q9BZE3* / P63157* / BARHL1* / BarH like homeobox 1* / BarH-like 1 homeobox protein *ENSDARG0000001901318
dbx1a / Q9PTU1 / developing brain homeobox 1a / DBX1* / A6NMT0* / P52950* / Homeobox protein DBX1 * / developing brain homeobox 1*ENSDARG0000008639318
dbx1b / developing brain homeobox 1b / DBX1* / P52950* / A6NMT0* / Homeobox protein DBX1 * / developing brain homeobox 1*ENSDARG0000000185918
tlx1 / T cell leukemia homeobox 1 / P31314*ENSDARG0000000396518
barhl1a / BarH-like homeobox 1a / Q9BZE3* / P63157* / BARHL1* / BarH like homeobox 1* / BarH-like 1 homeobox protein *ENSDARG0000003550817
bsx / Q6R3Q6 / brain-specific homeobox / Q3C1V8* / Q810B3* / Brain-specific homeobox protein homolog *ENSDARG0000006897616
barx2 / BARX homeobox 2 / O08686* / Q9UMQ3* / Homeobox protein BarH-like 2 *ENSDARG0000004109816
lbx1a / ladybird homeobox 1a / LBX1* / P52954* / P52955* / ladybird homeobox 1* / Transcription factor LBX1 *ENSDARG0000001832114
lbx2 / ladybird homeobox 2ENSDARG0000002513114
HHEX / hematopoietically expressed homeobox / Q03014*ENSDARG0000009823113
barx1 / BARX homeobox 1 / Q9ER42* / Q9HBU1* / Homeobox protein BarH-like 1 *ENSDARG0000000740713
lbx1b / ladybird homeobox 1b / LBX1* / P52954* / P52955* / ladybird homeobox 1* / Transcription factor LBX1 *ENSDARG0000001861112


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0003309 type B pancreatic cell differentiation IEA
 biological_processGO:0003310 pancreatic A cell differentiation IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0021522 spinal cord motor neuron differentiation IMP
 biological_processGO:0030516 regulation of axon extension IEA
 biological_processGO:0031018 endocrine pancreas development IMP
 biological_processGO:0045165 cell fate commitment IMP
 biological_processGO:0050796 regulation of insulin secretion IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000254 pancreas primordium pancreas primordium has fewer parts of type endocrine cell , abnormal
Show

 ZFA:0001390 pancreatic bud pancreatic bud has fewer parts of type endocrine cell , abnormal
pancreatic bud has fewer parts of type pancreatic A cell , abnormal
pancreatic bud absent , abnormal
Show

 ZFA:0005177 VeLD VeLD increased amount , abnormal
Show

 ZFA:0009103 glucagon secreting cell glucagon secreting cell decreased amount , abnormal
Show

 ZFA:0009244 primary motor neuron primary motor neuron axon branched , abnormal
primary motor neuron axon decreased length , abnormal
primary motor neuron axon decreased amount , abnormal
Show

 ZFA:0009247 secondary motor neuron secondary motor neuron decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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