ENSMUSG00000035187


Mus musculus

Features
Gene ID: ENSMUSG00000035187
  
Biological name :Nkx6-1
  
Synonyms : Homeobox protein Nkx-6.1 / Nkx6-1 / Q99MA9
  
Possible biological names infered from orthology : NK6 homeobox 1 / P78426
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: E4
Gene start: 101658139
Gene end: 101664996
  
Corresponding Affymetrix probe sets: 10531790 (MoGene1.0st)   1425828_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000042716
NCBI entrez gene - 18096     See in Manteia.
MGI - MGI:1206039
RefSeq - NM_144955
RefSeq Peptide - NP_659204
swissprot - Q99MA9
Ensembl - ENSMUSG00000035187
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nkx6.1ENSDARG00000022569Danio rerio
 NKX6-1ENSGALG00000032545Gallus gallus
 NKX6-1ENSG00000163623Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nkx6-2 / NK6 homeobox 2 / Q9C056*ENSMUSG0000004130952
Nkx6-3 / Q3UHX8 / Homeobox protein Nkx-6.3 / A6NJ46* / NK6 homeobox 3*ENSMUSG0000006367237
Hlx / Q61670 / H2.0-like homeobox protein / Q14774* / H2.0 like homeobox*ENSMUSG0000003937722
Tlx3 / O55144 / T-cell leukemia homeobox protein 3 / O43711* / T cell leukemia homeobox 3*ENSMUSG0000004061019
Dbx1 / P52950 / Homeobox protein DBX1 / A6NMT0* / developing brain homeobox 1*ENSMUSG0000003050719
Tlx1 / T cell leukemia, homeobox 1 / P31314*ENSMUSG0000002521518
Barhl1 / P63157 / BarH-like 1 homeobox protein / Q9BZE3* / BarH like homeobox 1*ENSMUSG0000002680517
Barhl2 / Q8VIB5 / BarH-like 2 homeobox protein / Q9NY43* / BarH like homeobox 2*ENSMUSG0000003438417
Hhex / P43120 / Hematopoietically-expressed homeobox protein Hhex / Q03014* / hematopoietically expressed homeobox*ENSMUSG0000002498616
Dbx2 / developing brain homeobox 2 / Q6ZNG2*ENSMUSG0000004560816
Barx2 / O08686 / Homeobox protein BarH-like 2 / Q9UMQ3* / BARX homeobox 2*ENSMUSG0000003203316
Tlx2 / Q61663 / T cell leukemia, homeobox 2 / O43763*ENSMUSG0000006832716
Barx1 / Q9ER42 / Homeobox protein BarH-like 1 / Q9HBU1* / BARX homeobox 1*ENSMUSG0000002138115
Bsx / Q810B3 / Brain-specific homeobox protein homolog / Q3C1V8* / brain specific homeobox*ENSMUSG0000005436013
Lbx1 / P52955 / Transcription factor LBX1 / P52954* / ladybird homeobox 1*ENSMUSG0000002521613
Lbx2 / Q9WUN8 / Transcription factor LBX2 / Q6XYB7* / ladybird homeobox 2*ENSMUSG0000003496813


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa
 IPR033630  Homeobox protein NKX-6.1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0003309 type B pancreatic cell differentiation IEA
 biological_processGO:0003323 type B pancreatic cell development IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007224 smoothened signaling pathway IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0021912 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification IGI
 biological_processGO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification IMP
 biological_processGO:0021953 central nervous system neuron differentiation IMP
 biological_processGO:0022008 neurogenesis IEA
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0030516 regulation of axon extension IMP
 biological_processGO:0031018 endocrine pancreas development TAS
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0044342 type B pancreatic cell proliferation IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IDA
 biological_processGO:0045686 negative regulation of glial cell differentiation IGI
 biological_processGO:0045687 positive regulation of glial cell differentiation IGI
 biological_processGO:0048709 oligodendrocyte differentiation IGI
 biological_processGO:0050796 regulation of insulin secretion IEA
 biological_processGO:0071345 cellular response to cytokine stimulus IEA
 biological_processGO:0071375 cellular response to peptide hormone stimulus IEA
 biological_processGO:2001222 regulation of neuron migration IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000756 forelimb paralysis "loss of power of voluntary movement in muscles of the forlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nkx6-1tm1Jlr/Nkx6-1tm1.1Msan,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129 * C57BL/6 * DBA * SJL

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: P2ry2tm1Bhk/P2ry2tm1Bhk
Genetic Background: involves: 129P2/OlaHsd

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
Show

Allelic Composition: Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: P2ry2tm1Bhk/P2ry2tm1Bhk
Genetic Background: involves: 129P2/OlaHsd

 MP:0002948 abnormal neuronal specification "defects in the developmental patterning of neurons resulting in ectopic placement, decreased numbers or absence of mature neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:87948]
Show

Allelic Composition: P2ry2tm1Bhk/P2ry2tm1Bhk
Genetic Background: involves: 129P2/OlaHsd

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Tal1Hpt/Tal1Hpt
Genetic Background: (C57BL/6J x C3FeLe.B6-a/a)F1

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tal1Hpt/Tal1Hpt
Genetic Background: (C57BL/6J x C3FeLe.B6-a/a)F1

Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

Allelic Composition: Nkx6-1tm1Jlr/Nkx6-1tm1.1Msan,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Neurog3-cre)C1Able/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Nkx6-1tm1.1Msan/Nkx6-1+,Pdx1tm1Cvw/Pdx1+,Tg(Neurog3-cre)C1Able/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Nkx6-1tm1Jlr/Nkx6-1tm1.1Msan,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129 * C57BL/6 * DBA * SJL

Allelic Composition: Nkx6-1tm1Jlr/Nkx6-1tm1.2Msan
Genetic Background: involves: 129S6/SvEvTac * C57BL * DBA * SJL

 MP:0004100 abnormal spinal cord interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: P2ry2tm1Bhk/P2ry2tm1Bhk
Genetic Background: involves: 129P2/OlaHsd

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nkx6-1tm1.1Msan/Nkx6-1+,Pdx1tm1Cvw/Pdx1+,Tg(Neurog3-cre)C1Able/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Tal1Hpt/Tal1Hpt
Genetic Background: (C57BL/6J x C3FeLe.B6-a/a)F1

 MP:0009175 abnormal pancreatic beta cell differentiation "atypical production of or inability to produce the cells of the pancreas that secrete insulin, and/or accumulation of pancreatic beta cell precursors" [MESH:A03.734.414.131]
Show

Allelic Composition: Nkx6-1tm1Jlr/Nkx6-1tm1.1Msan,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Neurog3-cre)C1Able/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Nkx6-1tm1Jlr/Nkx6-1tm1.1Msan,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129 * C57BL/6 * DBA * SJL

 MP:0009176 increased pancreatic alpha cell number "increase in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
Show

Allelic Composition: Nkx6-1tm1Jlr/Nkx6-1tm1.1Msan,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Neurog3-cre)C1Able/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Nkx6-1tm1.1Msan/Nkx6-1+,Pdx1tm1Cvw/Pdx1+,Tg(Neurog3-cre)C1Able/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0009177 decreased pancreatic alpha cell number "reduction in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
Show

Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0009180 increased pancreatic delta cell number "increased number of the cells found in the pancreas that secrete somatostatin" [MESH:A03.556.875.875.440.854]
Show

Allelic Composition: Nkx6-1tm1Jlr/Nkx6-1tm1.1Msan,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Neurog3-cre)C1Able/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Nkx6-1tm1Jlr/Nkx6-1tm1.1Msan,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129 * C57BL/6 * DBA * SJL

 MP:0009186 decreased PP cell number "reduced number of the polygonal pancreatic polypeptide producing cells in the islets of Langerhans in the pancreas" [CL:0000696, MESH:A03.734.414.587]
Show

Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0009190 increased pancreatic epsilon cell number "increase in the number of the endocrine cells found in the Islets of Langerhans that produce the hormone ghrelin" [PMID:14970313]
Show

Allelic Composition: Nkx6-1tm1Jlr/Nkx6-1tm1.1Msan,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Neurog3-cre)C1Able/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0009254 disorganized pancreatic islets "derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nkx6-1tm1Jlr/Nkx6-1tm1.1Msan,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Neurog3-cre)C1Able/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: P2ry2tm1Bhk/P2ry2tm1Bhk
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Nkx6-1tm1Jlr/Nkx6-1tm1.2Msan
Genetic Background: involves: 129S6/SvEvTac * C57BL * DBA * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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