ENSMUSG00000030507


Mus musculus

Features
Gene ID: ENSMUSG00000030507
  
Biological name :Dbx1
  
Synonyms : Dbx1 / Homeobox protein DBX1 / P52950
  
Possible biological names infered from orthology : A6NMT0 / developing brain homeobox 1
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B4
Gene start: 49631499
Gene end: 49636849
  
Corresponding Affymetrix probe sets: 10563797 (MoGene1.0st)   1457012_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032717
NCBI entrez gene - 13172     See in Manteia.
MGI - MGI:94867
RefSeq - NM_001005232
RefSeq Peptide - NP_001005232
swissprot - P52950
Ensembl - ENSMUSG00000030507
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dbx1aENSDARG00000086393Danio rerio
 dbx1bENSDARG00000001859Danio rerio
 DBX1ENSGALG00000003965Gallus gallus
 DBX1ENSG00000109851Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dbx2 / developing brain homeobox 2 / Q6ZNG2*ENSMUSG0000004560830
Hlx / Q61670 / H2.0-like homeobox protein / Q14774* / H2.0 like homeobox*ENSMUSG0000003937730
Nkx6-1 / Q99MA9 / Homeobox protein Nkx-6.1 / P78426* / NK6 homeobox 1*ENSMUSG0000003518721
Hhex / P43120 / Hematopoietically-expressed homeobox protein Hhex / Q03014* / hematopoietically expressed homeobox*ENSMUSG0000002498619
Tlx3 / O55144 / T-cell leukemia homeobox protein 3 / O43711* / T cell leukemia homeobox 3*ENSMUSG0000004061018
Barx2 / O08686 / Homeobox protein BarH-like 2 / Q9UMQ3* / BARX homeobox 2*ENSMUSG0000003203318
Barx1 / Q9ER42 / Homeobox protein BarH-like 1 / Q9HBU1* / BARX homeobox 1*ENSMUSG0000002138118
Nkx6-2 / NK6 homeobox 2 / Q9C056*ENSMUSG0000004130917
Barhl1 / P63157 / BarH-like 1 homeobox protein / Q9BZE3* / BarH like homeobox 1*ENSMUSG0000002680517
Lbx1 / P52955 / Transcription factor LBX1 / P52954* / ladybird homeobox 1*ENSMUSG0000002521617
Barhl2 / Q8VIB5 / BarH-like 2 homeobox protein / Q9NY43* / BarH like homeobox 2*ENSMUSG0000003438416
Nkx6-3 / Q3UHX8 / Homeobox protein Nkx-6.3 / A6NJ46* / NK6 homeobox 3*ENSMUSG0000006367216
Tlx2 / Q61663 / T cell leukemia, homeobox 2 / O43763*ENSMUSG0000006832716
Bsx / Q810B3 / Brain-specific homeobox protein homolog / Q3C1V8* / brain specific homeobox*ENSMUSG0000005436015
Tlx1 / T cell leukemia, homeobox 1 / P31314*ENSMUSG0000002521515
Lbx2 / Q9WUN8 / Transcription factor LBX2 / Q6XYB7* / ladybird homeobox 2*ENSMUSG0000003496815


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISO
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0021521 ventral spinal cord interneuron specification IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Mao
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000846 abnormal medulla oblongata "anomaly in the most caudal region of the brainstem that lies directly rostral to the spinal cord; includes regions responsible for autonomic functions such as digestion, breathing and control of heart rate" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Pdx1tm1Cvw/Pdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dbx1tm2(cre)Apie/Dbx1+,Robo3tm1.1Ache/Robo3tm1.1Ache
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Flot1tm1.1Arte/Flot1tm1.1Arte,Flot2Gt(258D8)Cmhd/Flot2Gt(258D8)Cmhd,Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Flot1tm1.1Arte/Flot1tm1.1Arte,Flot2Gt(258D8)Cmhd/Flot2Gt(258D8)Cmhd,Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Pdx1tm1Cvw/Pdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001752 abnormal hypothalamus secretion "altered ability of the hypothalamus to release its contents" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Flot1tm1.1Arte/Flot1tm1.1Arte,Flot2Gt(258D8)Cmhd/Flot2Gt(258D8)Cmhd,Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Pdx1tm1Cvw/Pdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Flot1tm1.1Arte/Flot1tm1.1Arte,Flot2Gt(258D8)Cmhd/Flot2Gt(258D8)Cmhd,Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003245 abnormal GABA neuron morphology "malformation or absence of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Nefhtm1Jpj/Nefhtm1Jpj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003462 abnormal response to novel odor "altered investigative behavior from controls in reactions associated with exposing an animal to a novel odor" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Flot1tm1.1Arte/Flot1tm1.1Arte,Flot2Gt(258D8)Cmhd/Flot2Gt(258D8)Cmhd,Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004100 abnormal spinal cord interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nefhtm1Jpj/Nefhtm1Jpj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005267 abnormal olfactory cortex morphology "anomalous structure of piriform cortex, part of the olfactory tract, which receives its major afferents from the olfactory bulb, and is primarily responsible for the identification of odors" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83884]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Mao
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Flot1tm1.1Arte/Flot1tm1.1Arte,Flot2Gt(258D8)Cmhd/Flot2Gt(258D8)Cmhd,Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005423 abnormal somatic nervous system physiology "anomalous function of any of the cranial and spinal nerves or their ganglia or the peripheral sensory receptors" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nefhtm1Jpj/Nefhtm1Jpj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Flot1tm1.1Arte/Flot1tm1.1Arte,Flot2Gt(258D8)Cmhd/Flot2Gt(258D8)Cmhd,Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010745 abnormal pre-Botzinger complex morphology "any structural anomaly of the group of interneurons within the medulla oblongata s ventral respiratory group that are important for the generation of ventilatory (inspiratory) rhythmogenesis" [PMID:18826652]
Show

Allelic Composition: Pdx1tm1Cvw/Pdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dbx1tm2(cre)Apie/Dbx1+,Robo3tm1.1Ache/Robo3tm1.1Ache
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0010746 abnormal pre-Botzinger complex physiology "any functional anomaly of the group of interneurons within the medulla oblongata s ventral respiratory group that are important for the generation of ventilatory (inspiratory) rhythmogenesis" [PMID:18826652]
Show

Allelic Composition: Pdx1tm1Cvw/Pdx1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dbx1tm2(cre)Apie/Dbx1+,Robo3tm1.1Ache/Robo3tm1.1Ache
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Nefhtm1Jpj/Nefhtm1Jpj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dbx1tm1Tmj/Dbx1tm1Tmj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Dbx1tm2(cre)Apie/Dbx1+,Robo3tm1.1Ache/Robo3tm1.1Ache
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Flot1tm1.1Arte/Flot1tm1.1Arte,Flot2Gt(258D8)Cmhd/Flot2Gt(258D8)Cmhd,Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011957 decreased compensatory feeding amount "decreased amount of food consumed after a period of fasting" [MGI:csmith]
Show

Allelic Composition: Flot1tm1.1Arte/Flot1tm1.1Arte,Flot2Gt(258D8)Cmhd/Flot2Gt(258D8)Cmhd,Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr