ENSMUSG00000026805


Mus musculus

Features
Gene ID: ENSMUSG00000026805
  
Biological name :Barhl1
  
Synonyms : Barhl1 / BarH-like 1 homeobox protein / P63157
  
Possible biological names infered from orthology : BarH like homeobox 1 / Q9BZE3
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A3
Gene start: 28907679
Gene end: 28916668
  
Corresponding Affymetrix probe sets: 10481329 (MoGene1.0st)   1418811_at (Mouse Genome 430 2.0 Array)   1418812_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053147
Ensembl peptide - ENSMUSP00000109478
Ensembl peptide - ENSMUSP00000109480
NCBI entrez gene - 54422     See in Manteia.
MGI - MGI:1859288
RefSeq - XM_011239138
RefSeq - NM_001164186
RefSeq - NM_019446
RefSeq - XM_006498182
RefSeq - XM_006498183
RefSeq Peptide - NP_001157658
RefSeq Peptide - NP_001342363
RefSeq Peptide - NP_062319
swissprot - P63157
Ensembl - ENSMUSG00000026805
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 barhl1aENSDARG00000035508Danio rerio
 barhl1bENSDARG00000019013Danio rerio
 BARHL1ENSGALG00000043217Gallus gallus
 BARHL1ENSG00000125492Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Barhl2 / Q8VIB5 / BarH-like 2 homeobox protein / Q9NY43* / BarH like homeobox 2*ENSMUSG0000003438462
Barx2 / O08686 / Homeobox protein BarH-like 2 / Q9UMQ3* / BARX homeobox 2*ENSMUSG0000003203323
Tlx3 / O55144 / T-cell leukemia homeobox protein 3 / O43711* / T cell leukemia homeobox 3*ENSMUSG0000004061022
Tlx2 / Q61663 / T cell leukemia, homeobox 2 / O43763*ENSMUSG0000006832721
Tlx1 / T cell leukemia, homeobox 1 / P31314*ENSMUSG0000002521520
Lbx1 / P52955 / Transcription factor LBX1 / P52954* / ladybird homeobox 1*ENSMUSG0000002521620
Nkx6-1 / Q99MA9 / Homeobox protein Nkx-6.1 / P78426* / NK6 homeobox 1*ENSMUSG0000003518719
Hlx / Q61670 / H2.0-like homeobox protein / Q14774* / H2.0 like homeobox*ENSMUSG0000003937718
Barx1 / Q9ER42 / Homeobox protein BarH-like 1 / Q9HBU1* / BARX homeobox 1*ENSMUSG0000002138118
Bsx / Q810B3 / Brain-specific homeobox protein homolog / Q3C1V8* / brain specific homeobox*ENSMUSG0000005436018
Nkx6-3 / Q3UHX8 / Homeobox protein Nkx-6.3 / A6NJ46* / NK6 homeobox 3*ENSMUSG0000006367217
Hhex / P43120 / Hematopoietically-expressed homeobox protein Hhex / Q03014* / hematopoietically expressed homeobox*ENSMUSG0000002498617
Dbx1 / P52950 / Homeobox protein DBX1 / A6NMT0* / developing brain homeobox 1*ENSMUSG0000003050717
Lbx2 / Q9WUN8 / Transcription factor LBX2 / Q6XYB7* / ladybird homeobox 2*ENSMUSG0000003496817
Nkx6-2 / NK6 homeobox 2 / Q9C056*ENSMUSG0000004130917
Dbx2 / developing brain homeobox 2 / Q6ZNG2*ENSMUSG0000004560813


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0030901 midbrain development IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0001967 deafness "inability to hear" [J:57651]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0004748 increased susceptibility to age-related hearing loss "greater than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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