ENSMUSG00000024986


Mus musculus

Features
Gene ID: ENSMUSG00000024986
  
Biological name :Hhex
  
Synonyms : Hematopoietically-expressed homeobox protein Hhex / Hhex / P43120
  
Possible biological names infered from orthology : hematopoietically expressed homeobox / Q03014
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C2
Gene start: 37434810
Gene end: 37440731
  
Corresponding Affymetrix probe sets: 10462818 (MoGene1.0st)   1423319_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025944
Ensembl peptide - ENSMUSP00000133688
NCBI entrez gene - 15242     See in Manteia.
MGI - MGI:96086
RefSeq - NM_008245
RefSeq Peptide - NP_032271
swissprot - G3UXH1
swissprot - P43120
Ensembl - ENSMUSG00000024986
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HHEXENSDARG00000098231Danio rerio
 HHEXENSGALG00000030008Gallus gallus
 HHEXENSG00000152804Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hlx / Q61670 / H2.0-like homeobox protein / Q14774* / H2.0 like homeobox*ENSMUSG0000003937726
Dbx1 / P52950 / Homeobox protein DBX1 / A6NMT0* / developing brain homeobox 1*ENSMUSG0000003050724
Tlx3 / O55144 / T-cell leukemia homeobox protein 3 / O43711* / T cell leukemia homeobox 3*ENSMUSG0000004061023
Nkx6-1 / Q99MA9 / Homeobox protein Nkx-6.1 / P78426* / NK6 homeobox 1*ENSMUSG0000003518722
Tlx2 / Q61663 / T cell leukemia, homeobox 2 / O43763*ENSMUSG0000006832722
Tlx1 / T cell leukemia, homeobox 1 / P31314*ENSMUSG0000002521521
Lbx1 / P52955 / Transcription factor LBX1 / P52954* / ladybird homeobox 1*ENSMUSG0000002521621
Barhl2 / Q8VIB5 / BarH-like 2 homeobox protein / Q9NY43* / BarH like homeobox 2*ENSMUSG0000003438421
Lbx2 / Q9WUN8 / Transcription factor LBX2 / Q6XYB7* / ladybird homeobox 2*ENSMUSG0000003496821
Nkx6-2 / NK6 homeobox 2 / Q9C056*ENSMUSG0000004130921
Bsx / Q810B3 / Brain-specific homeobox protein homolog / Q3C1V8* / brain specific homeobox*ENSMUSG0000005436020
Nkx6-3 / Q3UHX8 / Homeobox protein Nkx-6.3 / A6NJ46* / NK6 homeobox 3*ENSMUSG0000006367220
Barhl1 / P63157 / BarH-like 1 homeobox protein / Q9BZE3* / BarH like homeobox 1*ENSMUSG0000002680520
Barx2 / O08686 / Homeobox protein BarH-like 2 / Q9UMQ3* / BARX homeobox 2*ENSMUSG0000003203320
Dbx2 / developing brain homeobox 2 / Q6ZNG2*ENSMUSG0000004560818
Barx1 / Q9ER42 / Homeobox protein BarH-like 1 / Q9HBU1* / BARX homeobox 1*ENSMUSG0000002138118


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001889 liver development IMP
 biological_processGO:0002009 morphogenesis of an epithelium IMP
 biological_processGO:0002573 myeloid leukocyte differentiation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006406 mRNA export from nucleus IEA
 biological_processGO:0007165 signal transduction IMP
 biological_processGO:0007219 Notch signaling pathway IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007492 endoderm development IMP
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016525 negative regulation of angiogenesis IDA
 biological_processGO:0016973 poly(A)+ mRNA export from nucleus IEA
 biological_processGO:0022027 interkinetic nuclear migration IMP
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IMP
 biological_processGO:0030183 B cell differentiation IMP
 biological_processGO:0030878 thyroid gland development IMP
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway IDA
 biological_processGO:0031016 pancreas development IMP
 biological_processGO:0034504 protein localization to nucleus IEA
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048568 embryonic organ development IMP
 biological_processGO:0048729 tissue morphogenesis IMP
 biological_processGO:0048853 forebrain morphogenesis IMP
 biological_processGO:0060431 primary lung bud formation IMP
 biological_processGO:0061009 common bile duct development IMP
 biological_processGO:0061010 gall bladder development IMP
 biological_processGO:0061011 hepatic duct development IMP
 biological_processGO:0061017 hepatoblast differentiation IMP
 biological_processGO:0070365 hepatocyte differentiation IMP
 biological_processGO:0071103 DNA conformation change IEA
 biological_processGO:0090009 primitive streak formation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0032993 protein-DNA complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008190 eukaryotic initiation factor 4E binding IEA
 molecular_functionGO:0008301 DNA binding, bending IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding ISS
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0070491 repressing transcription factor binding IEA
 molecular_functionGO:0071837 HMG box domain binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0000297 abnormal endocardial cushion morphology "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0000596 abnormal liver development "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

Allelic Composition: Hhextm1Ngu/Hhextm1Ngu
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Tshz1tm1Core/Tshz1tm1Core
Genetic Background: B6.129P2-Tshz1tm1Core

Allelic Composition: Hhextm1Cwb/Hhextm2Cwb,Tg(Foxa3-cre)1Khk/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA * SJL

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Hhextm1Cwb/Hhextm2Cwb,Tg(Foxa3-cre)1Khk/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA * SJL

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gja1tm1Kdr/Gja1tm1Kdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000681 abnormal thyroid gland morphology "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Gofm4C3H/HeJ/?
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Gmnntm1Tjm/Gmnn+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Gofm4C3H/HeJ/?
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0000936 small telencephalic vesicles "reduced size of the paired diverticula of the telencephalon, from which the forebrain develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Gofm4C3H/HeJ/?
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Gofm4C3H/HeJ/?
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Hhextm1Ngu/Hhextm1Ngu
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mpzttrr/Mpzttrr
Genetic Background: B6.Cg-Mpzttrr/GrsrJ

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0002231 abnormal primitive streak morphology "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Gmnntm1Tjm/Gmnn+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0002745 abnormal atrioventricular valve morphology "malformation of the valves that gate the flow of blood from the atria into the ventricles" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0002929 abnormal bile duct development "incomplete or aberrant differentiation of the channels that secrete bile from the liver to the gall bladder and intestines" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Tshz1tm1Core/Tshz1tm1Core
Genetic Background: B6.129P2-Tshz1tm1Core

 MP:0003085 abnormal egg cylinder morphology "anomaly in the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Gmnntm1Tjm/Gmnn+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

Allelic Composition: Hhextm1Rbe/Hhextm1Rbe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003250 absent gall bladder "absence of the organ which serves as a storage reservoir for bile" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Hhextm1Cwb/Hhextm2Cwb,Tg(Foxa3-cre)1Khk/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA * SJL

 MP:0003266 biliary cysts "the appearance of fluid-filled sacs within the bile ducts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Hhextm1Cwb/Hhextm2Cwb,Tg(Foxa3-cre)1Khk/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA * SJL

 MP:0003327 liver cysts "abnormal membranous sacs in any portion of the liver" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Tshz1tm1Core/Tshz1tm1Core
Genetic Background: B6.129P2-Tshz1tm1Core

Allelic Composition: Hhextm1Cwb/Hhextm2Cwb,Tg(Alb1-cre)1Khk/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Hhextm1Cwb/Hhextm2Cwb,Tg(Foxa3-cre)1Khk/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA * SJL

 MP:0003421 abnormal thyroid gland development "failure or abnormality in the formation of the thyroid gland during organogenesis" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95017]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

Allelic Composition: Hhextm1Rbe/Hhextm1Rbe
Genetic Background: B6.129P2-Hhextm1Rbe

Allelic Composition: Hhextm1Rbe/Hhextm1Rbe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003425 abnormal optic vesicle formation "anomalous formation of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]
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Allelic Composition: Hhextm1Rbe/Hhextm1Rbe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003649 reduced right ventricle 
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0003808 enlarged endocardial cushions "larger than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [mac:Megan A. Cassell, Mouse Genome Informatics Curator]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0003814 vascular smooth muscle cell hypoplasia "decreased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hhextm1Rbe/Hhextm1Rbe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hhextm1.1Tmj/Hhex+
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0004057 thin myocardial compact layer "reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0004268 abnormal optic stalk morphology "any structural anomaly of the narrow, proximal portion of the optic vesicle which connects the embryonic eye and forebrain" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Hhextm1Rbe/Hhextm1Rbe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004276 abnormal medial ganglionic eminence morphology "any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the neocortex; however, hippocampal neurons, thalamus, septum and olfactory bulb neurons are also partly derived from the MGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Hhextm1Rbe/Hhextm1Rbe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006292 abnormal olfactory placode morphology "any structural abnormality in the paired ectodermal placodes that come to lie in the bottom of the olfactory pits as the pits are deepened by the growth of the surrounding medial and lateral nasal processes" [J:62024, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hhextm1Rbe/Hhextm1Rbe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006293 absent olfactory placodes "absence of the paired ectodermal placodes that come to lie in the bottom of the olfactory pits as the pits are deepened by the growth of the surrounding medial and lateral nasal processes " [J:71787, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hhextm1Rbe/Hhextm1Rbe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006337 abnormal first branchial arch morphology "anomaly in the structure of the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel s cartilage, trigeminal nerve, and maxillary artery" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hhextm1Rbe/Hhextm1Rbe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008112 abnormal monocyte differentiation "atypical production of or inability to produce the large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood" [CL:0000576, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hhextm1Ngu/Hhextm1Ngu
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008533 abnormal anterior visceral endoderm "any structural anomaly of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [PMID:17078044]
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Allelic Composition: Hhextm1.1Tmj/Hhex+
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0008825 abnormal cardiac epithelial to mesenchymal transition "anomaly in the process by which endocardial cells of the atrioventricular canal lose their epithelial characteristics, delaminante from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventaully forming the endocardial cushions reqired for septum and atrioventricular valve formation" [PMID:17303760]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0008926 abnormal anterior definitive endoderm morphology "any structural anomaly of the mesendoderm which first migrates from the node and which gives rise to the gut" [PMID:12464432]
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Allelic Composition: Hhextm1Rbe/Hhextm1Rbe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009497 abnormal intrahepatic bile duct morphology "any structural anomaly of the passages within the liver for the conveyance of bile" [MESH:A03.159.183.158]
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Allelic Composition: Hhextm1Cwb/Hhextm2Cwb,Tg(Foxa3-cre)1Khk/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA * SJL

 MP:0009498 abnormal extrahepatic bile duct morphology "any structural anomaly of the passages external to the liver for the conveyance of bile" [MESH:A03.159.183.079]
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Allelic Composition: Hhextm1Cwb/Hhextm2Cwb,Tg(Foxa3-cre)1Khk/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA * SJL

 MP:0009501 abnormal hepatic duct morphology "any structural anomaly of the two canals (left and right) that collect and drain bile from the left and right half of the liver from the biliary ductules and join external to the liver to form the common hepatic duct" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hhextm1Cwb/Hhextm2Cwb,Tg(Foxa3-cre)1Khk/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA * SJL

 MP:0010335 fused first branchial arch "the first arch fails to fully divide along the midline" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hhextm1Rbe/Hhextm1Rbe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0010449 heart right ventricle outflow tract stenosis "abnormal constriction or narrowing of part of the anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0010585 abnormal conotruncal ridge morphology "any structural anomaly of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8823298]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0010588 conotruncal ridge hyperplasia "overdevelopment or increased size of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8823298]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hhextm1.1Tmj/Hhex+
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Hhextm1Cwb/Hhextm2Cwb,Tg(Foxa3-cre)1Khk/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA * SJL

Allelic Composition: Hhextm1Jomb/Hhextm1Jomb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

Allelic Composition: Hhextm1Ngu/Hhextm1Ngu
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Hhextm1Rbe/Hhextm1Rbe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Hhextm1Rbe/Hhextm1Rbe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Hhextm1.1Tmj/Hhex+
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0011759 absent Rathke s pouch "absence of the diverticulum arsing from the embryonic buccal cavity from which the anterior lobe of the pituitary gland is developed" [MGI:anna]
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Allelic Composition: Hhextm1Rbe/Hhextm1Rbe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011877 absent liver "absence of the bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage" [MGI:Colin_McKerlie]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

Allelic Composition: Hhextm1Rbe/Hhextm1Rbe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012136 absent forebrain "absence of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
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Allelic Composition: Hhextm1Rbe/Hhextm1Rbe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012138 decreased forebrain size "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
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Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

Allelic Composition: Hhextm1Rbe/Hhextm1Rbe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012157 rostral body truncation "rostral part of body truncated; typically with the caudal portion of the body relatively normal" [MGI:csmith]
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Allelic Composition: Hhextm1Rbe/Hhextm1Rbe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012234 abnormal hepatic diverticulum morphology "any structural anomaly of the out-pocket of thickened ventral foregut epithelium adjacent to the developing heart that constitutes the first morphological sign of the embryonic liver" [MGI:anna]
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Allelic Composition: Hhextm1Rbe/Hhextm1Rbe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012235 abnormal liver bud morphology "any structural anomaly of the liver primordium formed as hepatoblasts delaminate from the anterior portion of the hepatic diverticulum and invade the adjacent septum transversum mesenchyme" [MGI:anna]
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Allelic Composition: Hhextm1Ngu/Hhextm1Ngu
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0012245 abnormal hepatoblast migration "atypical migration of hepatoblasts across the basement membrane of the liver bud and/or invasion of the neighboring septum transversum mesenchyme" [MGI:anna]
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Allelic Composition: Hhextm1Rbe/Hhextm1Rbe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012501 abnormal pericardial cavity morphology "any structural anomaly of the anatomical body cavity in which the heart lies; the pericardial cavity forms in the lateral plate mesoderm above the buccopharyngeal membrane, as part of the early intraembryonic coelom, and is initially continuous with the two early pleural cavities" [MGI:anna]
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Allelic Composition: Hhextm1Rbe/Hhextm1Rbe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013906 absent embryonic telencephalon "absence of the paired diverticula of the embryonic telencephalon, from which the forebrain develops" [MGI:Anna]
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Allelic Composition: Hhextm1Rbe/Hhextm1Rbe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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