ENSGALG00000030008


Gallus gallus

Features
Gene ID: ENSGALG00000030008
  
Biological name :HHEX
  
Synonyms : hematopoietically-expressed homeobox protein HHEX / HHEX
  
Possible biological names infered from orthology : hematopoietically expressed homeobox / P43120 / Q03014
  
Species: Gallus gallus
  
Chr. number: 6
Strand: -1
Band:
Gene start: 20697338
Gene end: 20701603
  
Corresponding Affymetrix probe sets: Gga.3316.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000054964
NCBI entrez gene - 396182     See in Manteia.
RefSeq - NM_205252
RefSeq Peptide - NP_990583
swissprot - A0A1D5PQ05
Ensembl - ENSGALG00000030008
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HHEXENSDARG00000098231Danio rerio
 HHEXENSG00000152804Homo sapiens
 HhexENSMUSG00000024986Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HLX / H2.0 like homeobox / Q14774* / Q61670* / H2.0-like homeobox protein *ENSGALG0000003725723
DBX1 / developing brain homeobox 1 / A6NMT0* / P52950* / Homeobox protein DBX1 *ENSGALG0000000396522
ENSGALG0000000219121
LBX1* / P52954* / P52955* / ladybird homeobox 1* / Transcription factor LBX1 *ENSGALG0000003418921
DBX2 / developing brain homeobox 2 / Q6ZNG2*ENSGALG0000000960421
BARX1 / Q9DED6 / Homeobox protein BarH-like 1b / Q9ER42* / Q9HBU1* / BARX homeobox 1* / Homeobox protein BarH-like 1 *ENSGALG0000003555720
NKX6-1 / NK6 homeobox 1 / P78426* / Q99MA9* / Homeobox protein Nkx-6.1 *ENSGALG0000003254519
BSX / Q6RFL5 / Brain-specific homeobox protein homolog / Q3C1V8* / Q810B3* / brain specific homeobox*ENSGALG0000000651519
TLX1 / T-cell leukemia homeobox protein 1 / P31314* / T cell leukemia homeobox 1*ENSGALG0000000783119
BARHL2 / BarH like homeobox 2 / Q8VIB5* / Q9NY43* / BarH-like 2 homeobox protein *ENSGALG0000004006919
NKX6-2 / NK6 homeobox 2 / Q9C056*ENSGALG0000001050019
BARX2 / BARX homeobox 2 / O08686* / Q9UMQ3* / Homeobox protein BarH-like 2 *ENSGALG0000002938218
BARHL1 / BarH like homeobox 1 / P63157* / Q9BZE3* / BarH-like 1 homeobox protein *ENSGALG0000004321718
NKX6-3 / NK6 homeobox 3 / A6NJ46* / Q3UHX8* / Homeobox protein Nkx-6.3 *ENSGALG0000001850317


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001570 vasculogenesis IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0002009 morphogenesis of an epithelium IEA
 biological_processGO:0002573 myeloid leukocyte differentiation IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006406 mRNA export from nucleus IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007492 endoderm development IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0016973 poly(A)+ mRNA export from nucleus IEA
 biological_processGO:0022027 interkinetic nuclear migration IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IEA
 biological_processGO:0030183 B cell differentiation IEA
 biological_processGO:0030878 thyroid gland development IEA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0031016 pancreas development IEA
 biological_processGO:0034504 protein localization to nucleus IEA
 biological_processGO:0035050 embryonic heart tube development IEA
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048568 embryonic organ development IEA
 biological_processGO:0048729 tissue morphogenesis IEA
 biological_processGO:0048853 forebrain morphogenesis IEA
 biological_processGO:0060431 primary lung bud formation IEA
 biological_processGO:0061009 common bile duct development IEA
 biological_processGO:0061010 gall bladder development IEA
 biological_processGO:0061011 hepatic duct development IEA
 biological_processGO:0061017 hepatoblast differentiation IEA
 biological_processGO:0070365 hepatocyte differentiation IEA
 biological_processGO:0071103 DNA conformation change IEA
 biological_processGO:0090009 primitive streak formation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0032993 protein-DNA complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008190 eukaryotic initiation factor 4E binding IEA
 molecular_functionGO:0008301 DNA binding, bending IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0070491 repressing transcription factor binding IEA
 molecular_functionGO:0071837 HMG box domain binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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