ENSGALG00000010500


Gallus gallus

Features
Gene ID: ENSGALG00000010500
  
Biological name :NKX6-2
  
Synonyms : NK6 homeobox 2 / NKX6-2
  
Possible biological names infered from orthology : Q9C056
  
Species: Gallus gallus
  
Chr. number: 6
Strand: -1
Band:
Gene start: 35311072
Gene end: 35313308
  
Corresponding Affymetrix probe sets: Gga.2725.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000018279
NCBI entrez gene - 395591     See in Manteia.
RefSeq - NM_001199548
RefSeq - XM_015288987
RefSeq Peptide - NP_001186477
swissprot - F1NNJ9
Ensembl - ENSGALG00000010500
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nkx6.2ENSDARG00000104735Danio rerio
 NKX6-2ENSG00000148826Homo sapiens
 Nkx6-2ENSMUSG00000041309Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NKX6-1 / NK6 homeobox 1 / P78426* / Q99MA9* / Homeobox protein Nkx-6.1 *ENSGALG0000003254561
NKX6-3 / NK6 homeobox 3 / A6NJ46* / Q3UHX8* / Homeobox protein Nkx-6.3 *ENSGALG0000001850346
HLX / H2.0 like homeobox / Q14774* / Q61670* / H2.0-like homeobox protein *ENSGALG0000003725723
ENSGALG0000000219121
BARHL2 / BarH like homeobox 2 / Q8VIB5* / Q9NY43* / BarH-like 2 homeobox protein *ENSGALG0000004006920
HHEX / hematopoietically-expressed homeobox protein HHEX / P43120* / Q03014* / hematopoietically expressed homeobox*ENSGALG0000003000819
BARHL1 / BarH like homeobox 1 / P63157* / Q9BZE3* / BarH-like 1 homeobox protein *ENSGALG0000004321719
BARX2 / BARX homeobox 2 / O08686* / Q9UMQ3* / Homeobox protein BarH-like 2 *ENSGALG0000002938219
TLX1 / T-cell leukemia homeobox protein 1 / P31314* / T cell leukemia homeobox 1*ENSGALG0000000783119
DBX1 / developing brain homeobox 1 / A6NMT0* / P52950* / Homeobox protein DBX1 *ENSGALG0000000396519
DBX2 / developing brain homeobox 2 / Q6ZNG2*ENSGALG0000000960418
BARX1 / Q9DED6 / Homeobox protein BarH-like 1b / Q9ER42* / Q9HBU1* / BARX homeobox 1* / Homeobox protein BarH-like 1 *ENSGALG0000003555717
LBX1* / P52954* / P52955* / ladybird homeobox 1* / Transcription factor LBX1 *ENSGALG0000003418916
BSX / Q6RFL5 / Brain-specific homeobox protein homolog / Q3C1V8* / Q810B3* / brain specific homeobox*ENSGALG0000000651516


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0010454 negative regulation of cell fate commitment IEA
 biological_processGO:0010455 positive regulation of cell fate commitment IEA
 biological_processGO:0021912 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification IEA
 biological_processGO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification IEA
 biological_processGO:0022010 central nervous system myelination IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031018 endocrine pancreas development IEA
 biological_processGO:0031641 regulation of myelination IEA
 biological_processGO:0045686 negative regulation of glial cell differentiation IEA
 biological_processGO:0045687 positive regulation of glial cell differentiation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0048709 oligodendrocyte differentiation IEA
 biological_processGO:0050885 neuromuscular process controlling balance IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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