ENSGALG00000032545


Gallus gallus

Features
Gene ID: ENSGALG00000032545
  
Biological name :NKX6-1
  
Synonyms : NK6 homeobox 1 / NKX6-1
  
Possible biological names infered from orthology : Homeobox protein Nkx-6.1 / P78426 / Q99MA9
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 47115931
Gene end: 47116966
  
Corresponding Affymetrix probe sets: Gga.4083.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000057070
NCBI entrez gene - 395752     See in Manteia.
RefSeq - XM_015276473
swissprot - A0A1D5PVU2
Ensembl - ENSGALG00000032545
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nkx6.1ENSDARG00000022569Danio rerio
 NKX6-1ENSG00000163623Homo sapiens
 Nkx6-1ENSMUSG00000035187Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NKX6-2 / NK6 homeobox 2 / Q9C056*ENSGALG0000001050059
NKX6-3 / NK6 homeobox 3 / A6NJ46* / Q3UHX8* / Homeobox protein Nkx-6.3 *ENSGALG0000001850340
HLX / H2.0 like homeobox / Q14774* / Q61670* / H2.0-like homeobox protein *ENSGALG0000003725722
ENSGALG0000000219122
DBX1 / developing brain homeobox 1 / A6NMT0* / P52950* / Homeobox protein DBX1 *ENSGALG0000000396521
TLX1 / T-cell leukemia homeobox protein 1 / P31314* / T cell leukemia homeobox 1*ENSGALG0000000783120
BARHL2 / BarH like homeobox 2 / Q8VIB5* / Q9NY43* / BarH-like 2 homeobox protein *ENSGALG0000004006918
BARHL1 / BarH like homeobox 1 / P63157* / Q9BZE3* / BarH-like 1 homeobox protein *ENSGALG0000004321718
HHEX / hematopoietically-expressed homeobox protein HHEX / P43120* / Q03014* / hematopoietically expressed homeobox*ENSGALG0000003000818
BARX2 / BARX homeobox 2 / O08686* / Q9UMQ3* / Homeobox protein BarH-like 2 *ENSGALG0000002938217
LBX1* / P52954* / P52955* / ladybird homeobox 1* / Transcription factor LBX1 *ENSGALG0000003418916
DBX2 / developing brain homeobox 2 / Q6ZNG2*ENSGALG0000000960416
BARX1 / Q9DED6 / Homeobox protein BarH-like 1b / Q9ER42* / Q9HBU1* / BARX homeobox 1* / Homeobox protein BarH-like 1 *ENSGALG0000003555715
BSX / Q6RFL5 / Brain-specific homeobox protein homolog / Q3C1V8* / Q810B3* / brain specific homeobox*ENSGALG0000000651515


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa
 IPR033630  Homeobox protein NKX-6.1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0003309 type B pancreatic cell differentiation IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0021912 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification IEA
 biological_processGO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification IEA
 biological_processGO:0021953 central nervous system neuron differentiation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030516 regulation of axon extension IEA
 biological_processGO:0031018 endocrine pancreas development IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045686 negative regulation of glial cell differentiation IEA
 biological_processGO:0045687 positive regulation of glial cell differentiation IEA
 biological_processGO:0048709 oligodendrocyte differentiation IEA
 biological_processGO:0050796 regulation of insulin secretion IEA
 biological_processGO:2001222 regulation of neuron migration IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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