ENSG00000152804


Homo sapiens

Features
Gene ID: ENSG00000152804
  
Biological name :HHEX
  
Synonyms : hematopoietically expressed homeobox / HHEX / Q03014
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q23.33
Gene start: 92689951
Gene end: 92695646
  
Corresponding Affymetrix probe sets: 204689_at (Human Genome U133 Plus 2.0 Array)   215933_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000447953
Ensembl peptide - ENSP00000450017
Ensembl peptide - ENSP00000282728
NCBI entrez gene - 3087     See in Manteia.
OMIM - 604420
RefSeq - NM_002729
RefSeq Peptide - NP_002720
swissprot - F8VU08
swissprot - Q03014
Ensembl - ENSG00000152804
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HHEXENSDARG00000098231Danio rerio
 HHEXENSGALG00000030008Gallus gallus
 HhexENSMUSG00000024986Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HLX / Q14774 / H2.0 like homeoboxENSG0000013663026
NKX6-1 / P78426 / NK6 homeobox 1ENSG0000016362323
DBX1 / A6NMT0 / developing brain homeobox 1ENSG0000010985123
DBX2 / Q6ZNG2 / developing brain homeobox 2ENSG0000018561023
TLX3 / O43711 / T cell leukemia homeobox 3ENSG0000016443823
LBX1 / P52954 / ladybird homeobox 1ENSG0000013813623
TLX1 / P31314 / T cell leukemia homeobox 1ENSG0000010780721
TLX2 / O43763 / T cell leukemia homeobox 2ENSG0000011529721
BARHL2 / Q9NY43 / BarH like homeobox 2ENSG0000014303221
NKX6-2 / Q9C056 / NK6 homeobox 2ENSG0000014882621
BARX1 / Q9HBU1 / BARX homeobox 1ENSG0000013166821
BARHL1 / Q9BZE3 / BarH like homeobox 1ENSG0000012549220
LBX2 / Q6XYB7 / ladybird homeobox 2ENSG0000017952820
BARX2 / Q9UMQ3 / BARX homeobox 2ENSG0000004303920
BSX / Q3C1V8 / brain specific homeoboxENSG0000018890920
A6NJ46 / NKX6-3 / NK6 homeobox 3ENSG000001650668


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001570 vasculogenesis IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0002009 morphogenesis of an epithelium IEA
 biological_processGO:0002573 myeloid leukocyte differentiation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006406 mRNA export from nucleus IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007492 endoderm development IEA
 biological_processGO:0008283 cell proliferation IDA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0010621 negative regulation of transcription by transcription factor localization IC
 biological_processGO:0010944 negative regulation of transcription by competitive promoter binding TAS
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0016973 poly(A)+ mRNA export from nucleus IMP
 biological_processGO:0022027 interkinetic nuclear migration IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IEA
 biological_processGO:0030183 B cell differentiation IEA
 biological_processGO:0030878 thyroid gland development IEA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0031016 pancreas development IEA
 biological_processGO:0034504 protein localization to nucleus IDA
 biological_processGO:0035050 embryonic heart tube development IEA
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048568 embryonic organ development IEA
 biological_processGO:0048729 tissue morphogenesis IEA
 biological_processGO:0048853 forebrain morphogenesis IEA
 biological_processGO:0060431 primary lung bud formation IEA
 biological_processGO:0061009 common bile duct development IEA
 biological_processGO:0061010 gall bladder development IEA
 biological_processGO:0061011 hepatic duct development IEA
 biological_processGO:0061017 hepatoblast differentiation IEA
 biological_processGO:0070365 hepatocyte differentiation IEA
 biological_processGO:0071103 DNA conformation change IDA
 biological_processGO:0090009 primitive streak formation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0032993 protein-DNA complex IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0008190 eukaryotic initiation factor 4E binding IDA
 molecular_functionGO:0008301 DNA binding, bending IDA
 molecular_functionGO:0017025 TBP-class protein binding TAS
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding TAS
 molecular_functionGO:0070491 repressing transcription factor binding IDA
 molecular_functionGO:0071837 HMG box domain binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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