ENSG00000165066


Homo sapiens

Features
Gene ID: ENSG00000165066
  
Biological name :NKX6-3
  
Synonyms : A6NJ46 / NK6 homeobox 3 / NKX6-3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p11.21
Gene start: 41645178
Gene end: 41650669
  
Corresponding Affymetrix probe sets: 1552884_at (Human Genome U133 Plus 2.0 Array)   1552885_a_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428361
Ensembl peptide - ENSP00000429553
NCBI entrez gene - 157848     See in Manteia.
OMIM - 610772
RefSeq - NM_152568
RefSeq - XM_017013143
RefSeq Peptide - NP_689781
swissprot - A6NJ46
Ensembl - ENSG00000165066
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nkx6.3ENSDARG00000060529Danio rerio
 NKX6-3ENSGALG00000018503Gallus gallus
 Nkx6-3ENSMUSG00000063672Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NKX6-1 / P78426 / NK6 homeobox 1ENSG0000016362341
NKX6-2 / Q9C056 / NK6 homeobox 2ENSG0000014882641
HLX / Q14774 / H2.0 like homeoboxENSG0000013663020
BARHL1 / Q9BZE3 / BarH like homeobox 1ENSG0000012549219
DBX1 / A6NMT0 / developing brain homeobox 1ENSG0000010985119
BARHL2 / Q9NY43 / BarH like homeobox 2ENSG0000014303218
BARX1 / Q9HBU1 / BARX homeobox 1ENSG0000013166817
BARX2 / Q9UMQ3 / BARX homeobox 2ENSG0000004303916
HHEX / Q03014 / hematopoietically expressed homeoboxENSG0000015280416
DBX2 / Q6ZNG2 / developing brain homeobox 2ENSG0000018561015
TLX3 / O43711 / T cell leukemia homeobox 3ENSG0000016443813
BSX / Q3C1V8 / brain specific homeoboxENSG0000018890912
TLX2 / O43763 / T cell leukemia homeobox 2ENSG0000011529712
LBX1 / P52954 / ladybird homeobox 1ENSG0000013813611
LBX2 / Q6XYB7 / ladybird homeobox 2ENSG0000017952811
TLX1 / P31314 / T cell leukemia homeobox 1ENSG0000010780711


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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