ENSG00000138136


Homo sapiens

Features
Gene ID: ENSG00000138136
  
Biological name :LBX1
  
Synonyms : ladybird homeobox 1 / LBX1 / P52954
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q24.32
Gene start: 101226195
Gene end: 101229794
  
Corresponding Affymetrix probe sets: 208380_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000359212
NCBI entrez gene - 10660     See in Manteia.
OMIM - 604255
RefSeq - NM_006562
RefSeq Peptide - NP_006553
swissprot - P52954
Ensembl - ENSG00000138136
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lbx1aENSDARG00000018321Danio rerio
 lbx1bENSDARG00000018611Danio rerio
 ENSGALG00000034189Gallus gallus
 Lbx1ENSMUSG00000025216Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LBX2 / Q6XYB7 / ladybird homeobox 2ENSG0000017952838
HLX / Q14774 / H2.0 like homeoboxENSG0000013663024
BARHL2 / Q9NY43 / BarH like homeobox 2ENSG0000014303223
BARHL1 / Q9BZE3 / BarH like homeobox 1ENSG0000012549223
TLX1 / P31314 / T cell leukemia homeobox 1ENSG0000010780723
BARX2 / Q9UMQ3 / BARX homeobox 2ENSG0000004303923
TLX3 / O43711 / T cell leukemia homeobox 3ENSG0000016443822
HHEX / Q03014 / hematopoietically expressed homeoboxENSG0000015280422
DBX1 / A6NMT0 / developing brain homeobox 1ENSG0000010985120
TLX2 / O43763 / T cell leukemia homeobox 2ENSG0000011529720
BARX1 / Q9HBU1 / BARX homeobox 1ENSG0000013166820
BSX / Q3C1V8 / brain specific homeoboxENSG0000018890919
NKX6-1 / P78426 / NK6 homeobox 1ENSG0000016362318
NKX6-2 / Q9C056 / NK6 homeobox 2ENSG0000014882617
DBX2 / Q6ZNG2 / developing brain homeobox 2ENSG0000018561016
A6NJ46 / NKX6-3 / NK6 homeobox 3ENSG000001650665


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009653 anatomical structure morphogenesis TAS
 biological_processGO:0021522 spinal cord motor neuron differentiation IEA
 biological_processGO:0021920 regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0048663 neuron fate commitment IEA
 biological_processGO:0048664 neuron fate determination IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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