ENSMUSG00000025216


Mus musculus

Features
Gene ID: ENSMUSG00000025216
  
Biological name :Lbx1
  
Synonyms : Lbx1 / P52955 / Transcription factor LBX1
  
Possible biological names infered from orthology : ladybird homeobox 1 / P52954
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C3
Gene start: 45232684
Gene end: 45235812
  
Corresponding Affymetrix probe sets: 10468046 (MoGene1.0st)   1422323_a_at (Mouse Genome 430 2.0 Array)   1427400_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096997
NCBI entrez gene - 16814     See in Manteia.
MGI - MGI:104867
RefSeq - NM_010691
RefSeq - XM_006526722
RefSeq Peptide - NP_034821
swissprot - P52955
Ensembl - ENSMUSG00000025216
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lbx1aENSDARG00000018321Danio rerio
 lbx1bENSDARG00000018611Danio rerio
 ENSGALG00000034189Gallus gallus
 LBX1ENSG00000138136Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lbx2 / Q9WUN8 / Transcription factor LBX2 / Q6XYB7* / ladybird homeobox 2*ENSMUSG0000003496837
Hlx / Q61670 / H2.0-like homeobox protein / Q14774* / H2.0 like homeobox*ENSMUSG0000003937724
Barhl2 / Q8VIB5 / BarH-like 2 homeobox protein / Q9NY43* / BarH like homeobox 2*ENSMUSG0000003438423
Barx2 / O08686 / Homeobox protein BarH-like 2 / Q9UMQ3* / BARX homeobox 2*ENSMUSG0000003203323
Tlx1 / T cell leukemia, homeobox 1 / P31314*ENSMUSG0000002521523
Barhl1 / P63157 / BarH-like 1 homeobox protein / Q9BZE3* / BarH like homeobox 1*ENSMUSG0000002680523
Tlx3 / O55144 / T-cell leukemia homeobox protein 3 / O43711* / T cell leukemia homeobox 3*ENSMUSG0000004061022
Hhex / P43120 / Hematopoietically-expressed homeobox protein Hhex / Q03014* / hematopoietically expressed homeobox*ENSMUSG0000002498621
Dbx1 / P52950 / Homeobox protein DBX1 / A6NMT0* / developing brain homeobox 1*ENSMUSG0000003050720
Barx1 / Q9ER42 / Homeobox protein BarH-like 1 / Q9HBU1* / BARX homeobox 1*ENSMUSG0000002138120
Tlx2 / Q61663 / T cell leukemia, homeobox 2 / O43763*ENSMUSG0000006832719
Bsx / Q810B3 / Brain-specific homeobox protein homolog / Q3C1V8* / brain specific homeobox*ENSMUSG0000005436018
Nkx6-1 / Q99MA9 / Homeobox protein Nkx-6.1 / P78426* / NK6 homeobox 1*ENSMUSG0000003518717
Nkx6-3 / Q3UHX8 / Homeobox protein Nkx-6.3 / A6NJ46* / NK6 homeobox 3*ENSMUSG0000006367216
Nkx6-2 / NK6 homeobox 2 / Q9C056*ENSMUSG0000004130916
Dbx2 / developing brain homeobox 2 / Q6ZNG2*ENSMUSG0000004560815


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0021522 spinal cord motor neuron differentiation IGI
 biological_processGO:0021920 regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IMP
 biological_processGO:0048663 neuron fate commitment IMP
 biological_processGO:0048664 neuron fate determination IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxc11tm1Mrc/Hoxc11+,Hoxd11tm1Mrc/Hoxd11tm1Mrc
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0000269 abnormal looping morphogenesis "atypical bending of the primitive heart tube during early development" [J:27443]
Show

Allelic Composition: Lbx1tm1Thbr/Lbx1tm1Thbr
Genetic Background: involves: 129S4/SvJae

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
Show

Allelic Composition: Kcnq1ot1tm4Tilg/Kcnq1ot1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * M. spretus

Allelic Composition: Lbx1tm1Thbr/Lbx1tm1Thbr
Genetic Background: involves: 129S4/SvJae

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
Show

Allelic Composition: Kcnq1ot1tm4Tilg/Kcnq1ot1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * M. spretus

Allelic Composition: Lbx1tm1Thbr/Lbx1tm1Thbr
Genetic Background: involves: 129S4/SvJae

 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kcnq1ot1tm4Tilg/Kcnq1ot1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * M. spretus

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lbx1tm1Thbr/Lbx1tm1Thbr
Genetic Background: involves: 129S4/SvJae

 MP:0000756 forelimb paralysis "loss of power of voluntary movement in muscles of the forlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lbx1tm1Thbr/Lbx1tm1Thbr
Genetic Background: involves: 129S4/SvJae

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kcnq1ot1tm4Tilg/Kcnq1ot1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * M. spretus

Allelic Composition: Lbx1tm1.1Khan/Lbx1tm1.1Khan,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Lbx1tm1.1Khan/Lbx1tm1.1Khan,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6JJcl * C57BL/6NCrlj * CBA/JNCrlj

 MP:0000846 abnormal medulla oblongata "anomaly in the most caudal region of the brainstem that lies directly rostral to the spinal cord; includes regions responsible for autonomic functions such as digestion, breathing and control of heart rate" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Lbx1tm1Thbr/Lbx1tm1Thbr
Genetic Background: involves: 129S4/SvJae

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Lbx1tm1.1Khan/Lbx1tm1.1Khan,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6JJcl * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11tm1Ssp,Hoxc11tm1Mrc/Hoxc11+,Hoxd11tm1Mrc/Hoxd11tm1Mrc
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lbx1tm1Thbr/Lbx1tm1Thbr
Genetic Background: involves: 129S4/SvJae

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lim2Aca47/Lim2Aca47
Genetic Background: C57BL/6J-Lim2Aca47

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Lbx1tm2Cbm/Lbx1tm3.1(cre)Cbm,Mapttm2Arbr/Mapt+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002948 abnormal neuronal specification "defects in the developmental patterning of neurons resulting in ectopic placement, decreased numbers or absence of mature neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:87948]
Show

Allelic Composition: Lbx1tm2Cbm/Lbx1tm3.1(cre)Cbm,Mapttm2Arbr/Mapt+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lbx1tm1Thbr/Lbx1tm1Thbr
Genetic Background: involves: 129S4/SvJae

 MP:0003090 abnormal muscle progenitor cell migration "defects in the movement of cells that will develop into muscle cells out of the somites and/or to the appropriate location in the body" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnq1ot1tm4Tilg/Kcnq1ot1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * M. spretus

Allelic Composition: Lbx1tm1Thbr/Lbx1tm1Thbr
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Lbx1tm1.1Khan/Lbx1tm1.1Khan,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6JJcl * C57BL/6NCrlj * CBA/JNCrlj

 MP:0003245 abnormal GABA neuron morphology "malformation or absence of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Kcnq1ot1tm4Tilg/Kcnq1ot1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * M. spretus

Allelic Composition: Lbx1tm1Gld/Lbx1tm1Gld,Tlx3tm1Sjk/Tlx3tm1Sjk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003247 abnormal glutaminergic neuron "malformation or absence of the neurons that utilize glutamate as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Kcnq1ot1tm4Tilg/Kcnq1ot1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * M. spretus

 MP:0003358 abnormal hypaxial muscle morphology "malformation of the muscles of the limbs" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnq1ot1tm4Tilg/Kcnq1ot1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * M. spretus

Allelic Composition: Lbx1tm1Thbr/Lbx1tm1Thbr
Genetic Background: involves: 129S4/SvJae

 MP:0003994 abnormal dorsal spinal root morphology "any anomaly, deformity, or malformation of the posterior bundle of nerves emerging from the spinal cord to join with the anterior/ventral nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lbx1tm1Thbr/Lbx1tm1Thbr
Genetic Background: involves: 129S4/SvJae

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnq1ot1tm4Tilg/Kcnq1ot1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * M. spretus

 MP:0005277 abnormal brainstem morphology "anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]
Show

Allelic Composition: Kif3atm2Gsn/Kif3atm2Gsn,Tg(Col2a1-cre)1Bhr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0006006 increased sensory neuron number "greater than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lbx1tm2Cbm/Lbx1tm3.1(cre)Cbm,Mapttm2Arbr/Mapt+
Genetic Background: involves: 129P2/OlaHsd

 MP:0006282 abnormal posterior horn morphology "any structural anomaly of the dorsal gray matter of the spinal cord" [J:77764, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lbx1tm1Thbr/Lbx1tm1Thbr
Genetic Background: involves: 129S4/SvJae

 MP:0006284 absent hypaxial muscle "absence of the muscles derived from the lateral myotome and lateral portion of the dermomyotome; these include the thoracic intercostal and abdominal muscles, limb muscles and superficial back muscles, as well as the diaphragm and the tip of the tongue" [J:86619, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnq1ot1tm4Tilg/Kcnq1ot1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * M. spretus

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp1tm1Sesh/Casp1+,Casp4del/Casp4+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lbx1tm2Cbm/Lbx1tm3.1(cre)Cbm,Mapttm2Arbr/Mapt+
Genetic Background: involves: 129P2/OlaHsd

 MP:0010551 abnormal coronary vessel morphology "any structural anomaly of any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lbx1tm1Thbr/Lbx1tm1Thbr
Genetic Background: involves: 129S4/SvJae

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lbx1tm1Thbr/Lbx1tm1Thbr
Genetic Background: involves: 129S4/SvJae

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Lim2Aca47/Lim2Aca47
Genetic Background: C57BL/6J-Lim2Aca47

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Kcnq1ot1tm4Tilg/Kcnq1ot1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * M. spretus

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Lbx1tm1Thbr/Lbx1tm1Thbr
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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