ENSMUSG00000034968


Mus musculus

Features
Gene ID: ENSMUSG00000034968
  
Biological name :Lbx2
  
Synonyms : Lbx2 / Q9WUN8 / Transcription factor LBX2
  
Possible biological names infered from orthology : ladybird homeobox 2 / Q6XYB7
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: C3
Gene start: 83086367
Gene end: 83088243
  
Corresponding Affymetrix probe sets: 10539316 (MoGene1.0st)   1420714_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047134
NCBI entrez gene - 16815     See in Manteia.
MGI - MGI:1342288
RefSeq - NM_010692
RefSeq Peptide - NP_034822
swissprot - Q9WUN8
Ensembl - ENSMUSG00000034968
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LBX2ENSG00000179528Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lbx1 / P52955 / Transcription factor LBX1 / P52954* / ladybird homeobox 1*ENSMUSG0000002521653
Tlx2 / Q61663 / T cell leukemia, homeobox 2 / O43763*ENSMUSG0000006832730
Hhex / P43120 / Hematopoietically-expressed homeobox protein Hhex / Q03014* / hematopoietically expressed homeobox*ENSMUSG0000002498629
Barhl2 / Q8VIB5 / BarH-like 2 homeobox protein / Q9NY43* / BarH like homeobox 2*ENSMUSG0000003438429
Barhl1 / P63157 / BarH-like 1 homeobox protein / Q9BZE3* / BarH like homeobox 1*ENSMUSG0000002680528
Tlx3 / O55144 / T-cell leukemia homeobox protein 3 / O43711* / T cell leukemia homeobox 3*ENSMUSG0000004061028
Tlx1 / T cell leukemia, homeobox 1 / P31314*ENSMUSG0000002521527
Hlx / Q61670 / H2.0-like homeobox protein / Q14774* / H2.0 like homeobox*ENSMUSG0000003937725
Barx2 / O08686 / Homeobox protein BarH-like 2 / Q9UMQ3* / BARX homeobox 2*ENSMUSG0000003203325
Dbx1 / P52950 / Homeobox protein DBX1 / A6NMT0* / developing brain homeobox 1*ENSMUSG0000003050725
Bsx / Q810B3 / Brain-specific homeobox protein homolog / Q3C1V8* / brain specific homeobox*ENSMUSG0000005436024
Nkx6-1 / Q99MA9 / Homeobox protein Nkx-6.1 / P78426* / NK6 homeobox 1*ENSMUSG0000003518724
Barx1 / Q9ER42 / Homeobox protein BarH-like 1 / Q9HBU1* / BARX homeobox 1*ENSMUSG0000002138124
Nkx6-2 / NK6 homeobox 2 / Q9C056*ENSMUSG0000004130923
Nkx6-3 / Q3UHX8 / Homeobox protein Nkx-6.3 / A6NJ46* / NK6 homeobox 3*ENSMUSG0000006367220
Dbx2 / developing brain homeobox 2 / Q6ZNG2*ENSMUSG0000004560819


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0008150 biological_process ND
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Lbx2tm1Fchn/Lbx2tm1Fchn,Pax3Sp/Pax3Sp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Lbx2tm1Fchn/Lbx2tm1Fchn,Pax3Sp/Pax3Sp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
Show

Allelic Composition: Lbx2tm1Fchn/Lbx2tm1Fchn,Pax3Sp/Pax3Sp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001081 abnormal cranial ganglia morphology "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
Show

Allelic Composition: Lbx2tm1Fchn/Lbx2tm1Fchn,Pax3Sp/Pax3Sp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Sh3bp2tm1Geha/Sh3bp2tm1Geha
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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