ENSMUSG00000068327


Mus musculus

Features
Gene ID: ENSMUSG00000068327
  
Biological name :Tlx2
  
Synonyms : Q61663 / T cell leukemia, homeobox 2 / Tlx2
  
Possible biological names infered from orthology : O43763
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: C3
Gene start: 83068324
Gene end: 83070293
  
Corresponding Affymetrix probe sets: 10545638 (MoGene1.0st)   1421770_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000087069
Ensembl peptide - ENSMUSP00000133420
NCBI entrez gene - 21909     See in Manteia.
MGI - MGI:1350935
RefSeq - NM_009392
RefSeq Peptide - NP_033418
swissprot - G3UWU0
swissprot - Q61663
Ensembl - ENSMUSG00000068327
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TLX2ENSG00000115297Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tlx3 / O55144 / T-cell leukemia homeobox protein 3 / O43711* / T cell leukemia homeobox 3*ENSMUSG0000004061061
Tlx1 / T cell leukemia, homeobox 1 / P31314*ENSMUSG0000002521558
Barhl2 / Q8VIB5 / BarH-like 2 homeobox protein / Q9NY43* / BarH like homeobox 2*ENSMUSG0000003438427
Barhl1 / P63157 / BarH-like 1 homeobox protein / Q9BZE3* / BarH like homeobox 1*ENSMUSG0000002680524
Hhex / P43120 / Hematopoietically-expressed homeobox protein Hhex / Q03014* / hematopoietically expressed homeobox*ENSMUSG0000002498621
Nkx6-1 / Q99MA9 / Homeobox protein Nkx-6.1 / P78426* / NK6 homeobox 1*ENSMUSG0000003518721
Nkx6-2 / NK6 homeobox 2 / Q9C056*ENSMUSG0000004130920
Lbx2 / Q9WUN8 / Transcription factor LBX2 / Q6XYB7* / ladybird homeobox 2*ENSMUSG0000003496820
Hlx / Q61670 / H2.0-like homeobox protein / Q14774* / H2.0 like homeobox*ENSMUSG0000003937720
Lbx1 / P52955 / Transcription factor LBX1 / P52954* / ladybird homeobox 1*ENSMUSG0000002521619
Barx2 / O08686 / Homeobox protein BarH-like 2 / Q9UMQ3* / BARX homeobox 2*ENSMUSG0000003203319
Bsx / Q810B3 / Brain-specific homeobox protein homolog / Q3C1V8* / brain specific homeobox*ENSMUSG0000005436018
Dbx1 / P52950 / Homeobox protein DBX1 / A6NMT0* / developing brain homeobox 1*ENSMUSG0000003050718
Nkx6-3 / Q3UHX8 / Homeobox protein Nkx-6.3 / A6NJ46* / NK6 homeobox 3*ENSMUSG0000006367218
Barx1 / Q9ER42 / Homeobox protein BarH-like 1 / Q9HBU1* / BARX homeobox 1*ENSMUSG0000002138118
Dbx2 / developing brain homeobox 2 / Q6ZNG2*ENSMUSG0000004560815


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001707 mesoderm formation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048484 enteric nervous system development IMP
 biological_processGO:0050774 negative regulation of dendrite morphogenesis IDA
 cellular_componentGO:0005634 nucleus ISA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding ISA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000489 abnormal large intestine morphology "structural or developmental anomalies of the intestinum crassum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aqp5tm1Amn/Aqp5tm1Amn
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Tlx2tm1Htno/Tlx2tm1Htno
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tlx2tm1Htno/Tlx2tm1Htno
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aqp5tm1Amn/Aqp5tm1Amn
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Tlx2tm1Htno/Tlx2tm1Htno
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tlx2tm1.1(cre)Rpk/Tlx2tm1.1(cre)Rpk
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001044 abnormal enteric nervous system morphology "malformation or absence of the part of the autonomic nervous system that innervates the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tlx2tm1Htno/Tlx2tm1Htno
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001045 abnormal enteric ganglia morphology "any strucutural anomaly or deformity of the groups of nerve cell bodies associated with the enteric neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aqp5tm1Amn/Aqp5tm1Amn
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Tlx2tm1Htno/Tlx2tm1Htno
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001046 abnormal enteric neuron morphology "malformed or absent neurons that innervate the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aqp5tm1Amn/Aqp5tm1Amn
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aqp5tm1Amn/Aqp5tm1Amn
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Tlx2tm1Htno/Tlx2tm1Htno
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tlx2tm1.1(cre)Rpk/Tlx2tm1.1(cre)Rpk
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aqp5tm1Amn/Aqp5tm1Amn
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aqp5tm1Amn/Aqp5tm1Amn
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Tlx2tm1Htno/Tlx2tm1Htno
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tlx2tm1.1(cre)Rpk/Tlx2tm1.1(cre)Rpk
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tlx2tm1Htno/Tlx2tm1Htno
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002230 abnormal primitive streak formation "anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002731 megacolon "extreme dilation of the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:40722]
Show

Allelic Composition: Aqp5tm1Amn/Aqp5tm1Amn
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Tlx2tm1Htno/Tlx2tm1Htno
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tlx2tm1.1(cre)Rpk/Tlx2tm1.1(cre)Rpk
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003270 intestinal obstruction "any impediment, blockage, or reversal of the normal flow of the intestinal contents toward the anus " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Prkar1atm2Gsm/Prkar1atm2Gsm,Tlx2tm1.1(cre)Rpk/Tlx2+
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/6N * DBA/2

 MP:0003290 hypoperistalsis "reduced intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkar1atm2Gsm/Prkar1atm2Gsm,Tlx2tm1.1(cre)Rpk/Tlx2+
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/6N * DBA/2

 MP:0005029 abnormal amnion "malformed innermost layer of the extraembryonic membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0006002 abnormal small intestinal transit time "increase or decrease in the time it takes for a bolus of material to pass through the small intestine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tlx2tm1.1(cre)Rpk/Tlx2tm1.1(cre)Rpk
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tlx2tm1Htno/Tlx2tm1Htno
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009480 distended cecum "an expansion in the volume of the large sac at the ileum and large intestine junction, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aqp5tm1Amn/Aqp5tm1Amn
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Tlx2tm1.1(cre)Rpk/Tlx2tm1.1(cre)Rpk
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009485 distended ileum "an expansion in the volume of the portion of the small intestine that extends from the jejunum to the colon, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aqp5tm1Amn/Aqp5tm1Amn
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0011881 distended duodenum "an expansion in the volume of the portion of the small intestine that extends from the pyloris to the junction with the jejunum, as by stretching or distention" [MGI:Colin_McKerlie]
Show

Allelic Composition: Prkar1atm2Gsm/Prkar1atm2Gsm,Tlx2tm1.1(cre)Rpk/Tlx2+
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/6N * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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