ENSMUSG00000025215


Mus musculus

Features
Gene ID: ENSMUSG00000025215
  
Biological name :Tlx1
  
Synonyms : T cell leukemia, homeobox 1 / Tlx1
  
Possible biological names infered from orthology : P31314
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C3
Gene start: 45150680
Gene end: 45156943
  
Corresponding Affymetrix probe sets: 10463482 (MoGene1.0st)   1450526_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026236
Ensembl peptide - ENSMUSP00000133627
NCBI entrez gene - 21908     See in Manteia.
MGI - MGI:98769
RefSeq - NM_021901
RefSeq - XM_006526915
RefSeq Peptide - NP_068701
swissprot - G3UXB9
swissprot - Q9QX99
Ensembl - ENSMUSG00000025215
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tlx1ENSDARG00000003965Danio rerio
 tlx2ENSDARG00000011273Danio rerio
 TLX1ENSGALG00000007831Gallus gallus
 TLX1ENSG00000107807Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tlx3 / O55144 / T-cell leukemia homeobox protein 3 / O43711* / T cell leukemia homeobox 3*ENSMUSG0000004061058
Tlx2 / Q61663 / T cell leukemia, homeobox 2 / O43763*ENSMUSG0000006832750
Barhl2 / Q8VIB5 / BarH-like 2 homeobox protein / Q9NY43* / BarH like homeobox 2*ENSMUSG0000003438422
Barhl1 / P63157 / BarH-like 1 homeobox protein / Q9BZE3* / BarH like homeobox 1*ENSMUSG0000002680520
Nkx6-1 / Q99MA9 / Homeobox protein Nkx-6.1 / P78426* / NK6 homeobox 1*ENSMUSG0000003518720
Lbx1 / P52955 / Transcription factor LBX1 / P52954* / ladybird homeobox 1*ENSMUSG0000002521619
Nkx6-2 / NK6 homeobox 2 / Q9C056*ENSMUSG0000004130918
Barx2 / O08686 / Homeobox protein BarH-like 2 / Q9UMQ3* / BARX homeobox 2*ENSMUSG0000003203317
Hhex / P43120 / Hematopoietically-expressed homeobox protein Hhex / Q03014* / hematopoietically expressed homeobox*ENSMUSG0000002498617
Nkx6-3 / Q3UHX8 / Homeobox protein Nkx-6.3 / A6NJ46* / NK6 homeobox 3*ENSMUSG0000006367217
Lbx2 / Q9WUN8 / Transcription factor LBX2 / Q6XYB7* / ladybird homeobox 2*ENSMUSG0000003496816
Barx1 / Q9ER42 / Homeobox protein BarH-like 1 / Q9HBU1* / BARX homeobox 1*ENSMUSG0000002138116
Hlx / Q61670 / H2.0-like homeobox protein / Q14774* / H2.0 like homeobox*ENSMUSG0000003937716
Dbx1 / P52950 / Homeobox protein DBX1 / A6NMT0* / developing brain homeobox 1*ENSMUSG0000003050715
Bsx / Q810B3 / Brain-specific homeobox protein homolog / Q3C1V8* / brain specific homeobox*ENSMUSG0000005436014
Dbx2 / developing brain homeobox 2 / Q6ZNG2*ENSMUSG0000004560814


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0000690 absent spleen "missing organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Tlx1tm1Thr/Tlx1tm1Thr
Genetic Background: involves: 129P2/OlaHsd * MF1

Allelic Composition: Tlx1tm1.1(cre/ERT2)Rygo/Tlx1tm1.1(cre/ERT2)Rygo
Genetic Background: involves: C57BL/6 * C57BL/6JJcl * C57BL/6NSlc

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: H2b/H2b,Ptcratm1Vbo/Ptcratm1Vbo,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0000965 abnormal sensory neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of sensory impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: H2b/H2b,Ptcratm1Vbo/Ptcratm1Vbo,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
Show

Allelic Composition: H2b/H2b,Ptcratm1Vbo/Ptcratm1Vbo,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0004100 abnormal spinal cord interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: H2b/H2b,Ptcratm1Vbo/Ptcratm1Vbo,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0006282 abnormal posterior horn morphology "any structural anomaly of the dorsal gray matter of the spinal cord" [J:77764, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tlx1tm1Sjk/Tlx1tm1Sjk,Tlx3tm1Sjk/Tlx3tm1Sjk
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

 MP:0009322 increased splenocyte apoptosis "increase in the number of spleen cells undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tlx1tm1Thr/Tlx1tm1Thr
Genetic Background: involves: 129P2/OlaHsd * MF1

 MP:0009323 abnormal spleen development "aberrant formation or incomplete differentiation of the organ that filters blood and stores red corpuscles and platelets" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Tlx1tm1Thr/Tlx1tm1Thr
Genetic Background: involves: 129P2/OlaHsd * MF1

 MP:0010178 increased number of Howell-Jolly bodies "abnormal presence of basophilic nuclear remnants of condensed DNA (1 to 2 um in diameter) in circulating erythrocytes, typically seen in severe hemolytic anemias or after splenectomy; these inclusions are normally removed by the spleen but will persist in individuals with functional hyposplenia or asplenia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0011263 abnormal spleen mesenchyme morphology "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing spleen" [ISBN:0-683-40008-8, MGI:csmith]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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