ENSMUSG00000054360


Mus musculus

Features
Gene ID: ENSMUSG00000054360
  
Biological name :Bsx
  
Synonyms : Brain-specific homeobox protein homolog / Bsx / Q810B3
  
Possible biological names infered from orthology : brain specific homeobox / Q3C1V8
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A5.1
Gene start: 40874127
Gene end: 40880057
  
Corresponding Affymetrix probe sets: 10584584 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000068057
NCBI entrez gene - 244813     See in Manteia.
MGI - MGI:2669849
RefSeq - NM_178245
RefSeq Peptide - NP_839976
swissprot - Q810B3
Ensembl - ENSMUSG00000054360
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bsxENSDARG00000068976Danio rerio
 BSXENSGALG00000006515Gallus gallus
 BSXENSG00000188909Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Barx1 / Q9ER42 / Homeobox protein BarH-like 1 / Q9HBU1* / BARX homeobox 1*ENSMUSG0000002138131
Barx2 / O08686 / Homeobox protein BarH-like 2 / Q9UMQ3* / BARX homeobox 2*ENSMUSG0000003203331
Hlx / Q61670 / H2.0-like homeobox protein / Q14774* / H2.0 like homeobox*ENSMUSG0000003937728
Barhl2 / Q8VIB5 / BarH-like 2 homeobox protein / Q9NY43* / BarH like homeobox 2*ENSMUSG0000003438427
Barhl1 / P63157 / BarH-like 1 homeobox protein / Q9BZE3* / BarH like homeobox 1*ENSMUSG0000002680526
Hhex / P43120 / Hematopoietically-expressed homeobox protein Hhex / Q03014* / hematopoietically expressed homeobox*ENSMUSG0000002498623
Tlx2 / Q61663 / T cell leukemia, homeobox 2 / O43763*ENSMUSG0000006832722
Tlx3 / O55144 / T-cell leukemia homeobox protein 3 / O43711* / T cell leukemia homeobox 3*ENSMUSG0000004061022
Dbx1 / P52950 / Homeobox protein DBX1 / A6NMT0* / developing brain homeobox 1*ENSMUSG0000003050722
Lbx1 / P52955 / Transcription factor LBX1 / P52954* / ladybird homeobox 1*ENSMUSG0000002521622
Nkx6-1 / Q99MA9 / Homeobox protein Nkx-6.1 / P78426* / NK6 homeobox 1*ENSMUSG0000003518721
Tlx1 / T cell leukemia, homeobox 1 / P31314*ENSMUSG0000002521520
Dbx2 / developing brain homeobox 2 / Q6ZNG2*ENSMUSG0000004560820
Lbx2 / Q9WUN8 / Transcription factor LBX2 / Q6XYB7* / ladybird homeobox 2*ENSMUSG0000003496820
Nkx6-2 / NK6 homeobox 2 / Q9C056*ENSMUSG0000004130919
Nkx6-3 / Q3UHX8 / Homeobox protein Nkx-6.3 / A6NJ46* / NK6 homeobox 3*ENSMUSG0000006367218


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007420 brain development ISS
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0042755 eating behavior IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0060056 mammary gland involution IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Bsxtm2Aoh/Bsxtm2Aoh
Genetic Background: either: 129S4/SvJae-Bsxtm2Aoh or (involves: 129S4/SvJae * C57BL/6)

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Bsxtm2Aoh/Bsxtm2Aoh
Genetic Background: either: 129S4/SvJae-Bsxtm2Aoh or (involves: 129S4/SvJae * C57BL/6)

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Pik3catm1Jdo/Pik3catm1Jdo
Genetic Background: B6.129S7(Cg)-Pik3catm1Jdo

Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pik3catm1Jdo/Pik3catm1Jdo
Genetic Background: B6.129S7(Cg)-Pik3catm1Jdo

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Bsxtm2Aoh/Bsxtm2Aoh
Genetic Background: either: 129S4/SvJae-Bsxtm2Aoh or (involves: 129S4/SvJae * C57BL/6)

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pik3catm1Jdo/Pik3catm1Jdo
Genetic Background: B6.129S7(Cg)-Pik3catm1Jdo

Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pik3catm1Jdo/Pik3catm1Jdo
Genetic Background: B6.129S7(Cg)-Pik3catm1Jdo

 MP:0006270 abnormal mammary gland growth during lactation "anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Bsxtm2Aoh/Bsxtm2Aoh
Genetic Background: either: 129S4/SvJae-Bsxtm2Aoh or (involves: 129S4/SvJae * C57BL/6)

 MP:0006271 abnormal involution of the mammary gland "anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Bsxtm2Aoh/Bsxtm2Aoh
Genetic Background: either: 129S4/SvJae-Bsxtm2Aoh or (involves: 129S4/SvJae * C57BL/6)

 MP:0010249 lactation failure "mammary glands do not secrete milk after parturition" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Bsxtm2Aoh/Bsxtm2Aoh
Genetic Background: either: 129S4/SvJae-Bsxtm2Aoh or (involves: 129S4/SvJae * C57BL/6)

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pik3catm1Jdo/Pik3catm1Jdo
Genetic Background: B6.129S7(Cg)-Pik3catm1Jdo

 MP:0011014 decreased core body temperature "reduced degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0011020 abnormal circadian temperature homeostasis "any anomaly in the process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours" [GO:0060086]
Show

Allelic Composition: Pik3catm1Jdo/Pik3catm1Jdo
Genetic Background: B6.129S7(Cg)-Pik3catm1Jdo

 MP:0014126 increased mammary gland apoptosis "increase in the number of any cells of a mammary gland undergoing programmed cell death" [MGI:Anna]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Bsxtm2Aoh/Bsxtm2Aoh
Genetic Background: either: 129S4/SvJae-Bsxtm2Aoh or (involves: 129S4/SvJae * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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