ENSMUSG00000040610


Mus musculus

Features
Gene ID: ENSMUSG00000040610
  
Biological name :Tlx3
  
Synonyms : O55144 / T-cell leukemia homeobox protein 3 / Tlx3
  
Possible biological names infered from orthology : O43711 / T cell leukemia homeobox 3
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A4
Gene start: 33200752
Gene end: 33203589
  
Corresponding Affymetrix probe sets: 10385048 (MoGene1.0st)   1450806_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047457
NCBI entrez gene - 27140     See in Manteia.
MGI - MGI:1351209
RefSeq - NM_019916
RefSeq Peptide - NP_064300
swissprot - O55144
Ensembl - ENSMUSG00000040610
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TLX3ENSG00000164438Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tlx1 / T cell leukemia, homeobox 1 / P31314*ENSMUSG0000002521567
Tlx2 / Q61663 / T cell leukemia, homeobox 2 / O43763*ENSMUSG0000006832760
Barhl2 / Q8VIB5 / BarH-like 2 homeobox protein / Q9NY43* / BarH like homeobox 2*ENSMUSG0000003438427
Barhl1 / P63157 / BarH-like 1 homeobox protein / Q9BZE3* / BarH like homeobox 1*ENSMUSG0000002680524
Nkx6-1 / Q99MA9 / Homeobox protein Nkx-6.1 / P78426* / NK6 homeobox 1*ENSMUSG0000003518723
Nkx6-2 / NK6 homeobox 2 / Q9C056*ENSMUSG0000004130922
Hhex / P43120 / Hematopoietically-expressed homeobox protein Hhex / Q03014* / hematopoietically expressed homeobox*ENSMUSG0000002498622
Lbx1 / P52955 / Transcription factor LBX1 / P52954* / ladybird homeobox 1*ENSMUSG0000002521622
Dbx1 / P52950 / Homeobox protein DBX1 / A6NMT0* / developing brain homeobox 1*ENSMUSG0000003050721
Lbx2 / Q9WUN8 / Transcription factor LBX2 / Q6XYB7* / ladybird homeobox 2*ENSMUSG0000003496819
Barx2 / O08686 / Homeobox protein BarH-like 2 / Q9UMQ3* / BARX homeobox 2*ENSMUSG0000003203319
Nkx6-3 / Q3UHX8 / Homeobox protein Nkx-6.3 / A6NJ46* / NK6 homeobox 3*ENSMUSG0000006367219
Hlx / Q61670 / H2.0-like homeobox protein / Q14774* / H2.0 like homeobox*ENSMUSG0000003937719
Barx1 / Q9ER42 / Homeobox protein BarH-like 1 / Q9HBU1* / BARX homeobox 1*ENSMUSG0000002138118
Bsx / Q810B3 / Brain-specific homeobox protein homolog / Q3C1V8* / brain specific homeobox*ENSMUSG0000005436017
Dbx2 / developing brain homeobox 2 / Q6ZNG2*ENSMUSG0000004560816


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001708 cell fate specification IMP
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0002087 regulation of respiratory gaseous exchange by neurological system process IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0007585 respiratory gaseous exchange IMP
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0045665 negative regulation of neuron differentiation IGI
 biological_processGO:0048665 neuron fate specification IGI
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: H2b/H2b,Ptcratm1Vbo/Ptcratm1Vbo,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0000965 abnormal sensory neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of sensory impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: H2b/H2b,Ptcratm1Vbo/Ptcratm1Vbo,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
Show

Allelic Composition: H2b/H2b,Ptcratm1Vbo/Ptcratm1Vbo,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0001957 apnea "absence of breathing; sometimes episodic" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17384]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Tlx3tm1(cre)Qima/Tlx3+
Genetic Background: involves: 129X1/SvJ

 MP:0003245 abnormal GABA neuron morphology "malformation or absence of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Lbx1tm1Gld/Lbx1tm1Gld,Tlx3tm1Sjk/Tlx3tm1Sjk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003247 abnormal glutaminergic neuron "malformation or absence of the neurons that utilize glutamate as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Lbx1tm1Gld/Lbx1tm1Gld,Tlx3tm1Sjk/Tlx3tm1Sjk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0004100 abnormal spinal cord interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

Allelic Composition: Tlx1tm1Sjk/Tlx1tm1Sjk,Tlx3tm1Sjk/Tlx3tm1Sjk
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Rag1tm1Mom/Rag1tm1Mom,Rasa3scat/Rasa3scat
Genetic Background: involves: 129S7/SvEvBrd * BALB/cBy

 MP:0005426 tachypnea "rapid breathing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0006282 abnormal posterior horn morphology "any structural anomaly of the dorsal gray matter of the spinal cord" [J:77764, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tlx1tm1Sjk/Tlx1tm1Sjk,Tlx3tm1Sjk/Tlx3tm1Sjk
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

 MP:0006283 medulloblastoma "a solid, cancerous tumor originating in the cerebellum of the brain and of primitive neuroectodermal origin " [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Tlx3tm1(cre)Qima/Tlx3+
Genetic Background: involves: 129X1/SvJ

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Wt1tm1Jae/Wt1tm1Jae
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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