ENSMUSG00000034384


Mus musculus

Features
Gene ID: ENSMUSG00000034384
  
Biological name :Barhl2
  
Synonyms : Barhl2 / BarH-like 2 homeobox protein / Q8VIB5
  
Possible biological names infered from orthology : BarH like homeobox 2 / Q9NY43
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: E5
Gene start: 106452523
Gene end: 106458166
  
Corresponding Affymetrix probe sets: 10532032 (MoGene1.0st)   1437555_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000084005
NCBI entrez gene - 104382     See in Manteia.
MGI - MGI:1859314
RefSeq - NM_001005477
RefSeq Peptide - NP_001005477
swissprot - Q8VIB5
Ensembl - ENSMUSG00000034384
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 barhl2ENSDARG00000104361Danio rerio
 BARHL2ENSGALG00000040069Gallus gallus
 BARHL2ENSG00000143032Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Barhl1 / P63157 / BarH-like 1 homeobox protein / Q9BZE3* / BarH like homeobox 1*ENSMUSG0000002680553
Tlx3 / O55144 / T-cell leukemia homeobox protein 3 / O43711* / T cell leukemia homeobox 3*ENSMUSG0000004061021
Barx2 / O08686 / Homeobox protein BarH-like 2 / Q9UMQ3* / BARX homeobox 2*ENSMUSG0000003203320
Tlx2 / Q61663 / T cell leukemia, homeobox 2 / O43763*ENSMUSG0000006832720
Tlx1 / T cell leukemia, homeobox 1 / P31314*ENSMUSG0000002521519
Barx1 / Q9ER42 / Homeobox protein BarH-like 1 / Q9HBU1* / BARX homeobox 1*ENSMUSG0000002138118
Hlx / Q61670 / H2.0-like homeobox protein / Q14774* / H2.0 like homeobox*ENSMUSG0000003937717
Lbx1 / P52955 / Transcription factor LBX1 / P52954* / ladybird homeobox 1*ENSMUSG0000002521617
Bsx / Q810B3 / Brain-specific homeobox protein homolog / Q3C1V8* / brain specific homeobox*ENSMUSG0000005436016
Nkx6-1 / Q99MA9 / Homeobox protein Nkx-6.1 / P78426* / NK6 homeobox 1*ENSMUSG0000003518716
Lbx2 / Q9WUN8 / Transcription factor LBX2 / Q6XYB7* / ladybird homeobox 2*ENSMUSG0000003496815
Hhex / P43120 / Hematopoietically-expressed homeobox protein Hhex / Q03014* / hematopoietically expressed homeobox*ENSMUSG0000002498615
Dbx1 / P52950 / Homeobox protein DBX1 / A6NMT0* / developing brain homeobox 1*ENSMUSG0000003050714
Nkx6-2 / NK6 homeobox 2 / Q9C056*ENSMUSG0000004130914
Nkx6-3 / Q3UHX8 / Homeobox protein Nkx-6.3 / A6NJ46* / NK6 homeobox 3*ENSMUSG0000006367214
Dbx2 / developing brain homeobox 2 / Q6ZNG2*ENSMUSG0000004560813


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001709 cell fate determination IMP
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0030516 regulation of axon extension IMP
 biological_processGO:0045165 cell fate commitment IDA
 biological_processGO:0045727 positive regulation of translation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
Show

Allelic Composition: Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003733 abnormal inner nuclear layer morphology "malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005241 abnormal retinal ganglion layer morphology "anomalous structure of the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Barhl2tm1Gan/Barhl2tm2(cre)Gan,Tg(CAG-Bgeo/GFP)21Lbe/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0008105 increased amacrine cell number "increase in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008106 decreased amacrine cell number "reduction in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008507 thin retinal ganglion layer "reduced thickness of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008511 thin retinal inner nuclear layer "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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