ENSMUSG00000063672


Mus musculus

Features
Gene ID: ENSMUSG00000063672
  
Biological name :Nkx6-3
  
Synonyms : Homeobox protein Nkx-6.3 / Nkx6-3 / Q3UHX8
  
Possible biological names infered from orthology : A6NJ46 / NK6 homeobox 3
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A2
Gene start: 23153269
Gene end: 23158948
  
Corresponding Affymetrix probe sets: 10570951 (MoGene1.0st)   1431899_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000071517
NCBI entrez gene - 74561     See in Manteia.
MGI - MGI:1921811
RefSeq - NM_029002
RefSeq Peptide - NP_083278
swissprot - B2RU70
swissprot - Q3UHX8
Ensembl - ENSMUSG00000063672
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nkx6.3ENSDARG00000060529Danio rerio
 NKX6-3ENSGALG00000018503Gallus gallus
 A6NJ46ENSG00000165066Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nkx6-1 / Q99MA9 / Homeobox protein Nkx-6.1 / P78426* / NK6 homeobox 1*ENSMUSG0000003518751
Nkx6-2 / NK6 homeobox 2 / Q9C056*ENSMUSG0000004130950
Hlx / Q61670 / H2.0-like homeobox protein / Q14774* / H2.0 like homeobox*ENSMUSG0000003937725
Tlx1 / T cell leukemia, homeobox 1 / P31314*ENSMUSG0000002521521
Barhl2 / Q8VIB5 / BarH-like 2 homeobox protein / Q9NY43* / BarH like homeobox 2*ENSMUSG0000003438421
Tlx3 / O55144 / T-cell leukemia homeobox protein 3 / O43711* / T cell leukemia homeobox 3*ENSMUSG0000004061021
Hhex / P43120 / Hematopoietically-expressed homeobox protein Hhex / Q03014* / hematopoietically expressed homeobox*ENSMUSG0000002498621
Barhl1 / P63157 / BarH-like 1 homeobox protein / Q9BZE3* / BarH like homeobox 1*ENSMUSG0000002680521
Dbx1 / P52950 / Homeobox protein DBX1 / A6NMT0* / developing brain homeobox 1*ENSMUSG0000003050720
Barx2 / O08686 / Homeobox protein BarH-like 2 / Q9UMQ3* / BARX homeobox 2*ENSMUSG0000003203319
Tlx2 / Q61663 / T cell leukemia, homeobox 2 / O43763*ENSMUSG0000006832719
Barx1 / Q9ER42 / Homeobox protein BarH-like 1 / Q9HBU1* / BARX homeobox 1*ENSMUSG0000002138118
Lbx1 / P52955 / Transcription factor LBX1 / P52954* / ladybird homeobox 1*ENSMUSG0000002521618
Dbx2 / developing brain homeobox 2 / Q6ZNG2*ENSMUSG0000004560818
Bsx / Q810B3 / Brain-specific homeobox protein homolog / Q3C1V8* / brain specific homeobox*ENSMUSG0000005436016
Lbx2 / Q9WUN8 / Transcription factor LBX2 / Q6XYB7* / ladybird homeobox 2*ENSMUSG0000003496815


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001709 cell fate determination IMP
 biological_processGO:0002067 glandular epithelial cell differentiation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0030857 negative regulation of epithelial cell differentiation IMP
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004137 abnormal gastric surface mucous cells "malformation of the mucus secreting epithelial cells that lline the luminal surface of the stomach, gastric pits and gastric glands" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdpk1tm1Jcbr/Pdpk1tm1Jcbr,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0004139 abnormal parietal cell morphology "malformation of the gastric acid producing epithelial cells that are distributed throughout the length of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdpk1tm1Jcbr/Pdpk1tm1Jcbr,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0004732 decreased circulating gastrin level "reduced concentration in the blood of polypeptide hormones secreted by the pyloric-antral mucous lining of the stomach that induces the secretion of gastric juice by the parietal cells of the gastric glands; they also occur in the central nervous system where they are presumed to be neurotransmitters" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Pdpk1tm1Jcbr/Pdpk1tm1Jcbr,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0008006 increased stomach pH "change in the function of the secretory and buffer systems of the stomach that control the relative acidity or alkalinity, such that the acidity is decreased, as indicated by the decreased concentration of hydrogen ion" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdpk1tm1Jcbr/Pdpk1tm1Jcbr,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0010803 abnormal stomach enteroendocrine cell morphology "any structural anomaly of the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the stomach" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdpk1tm1Jcbr/Pdpk1tm1Jcbr,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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