ENSG00000115297


Homo sapiens

Features
Gene ID: ENSG00000115297
  
Biological name :TLX2
  
Synonyms : O43763 / T cell leukemia homeobox 2 / TLX2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p13.1
Gene start: 74513463
Gene end: 74517147
  
Corresponding Affymetrix probe sets: 207410_s_at (Human Genome U133 Plus 2.0 Array)   211049_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000233638
Ensembl peptide - ENSP00000482690
NCBI entrez gene - 3196     See in Manteia.
OMIM - 604240
RefSeq - NM_016170
RefSeq Peptide - NP_057254
swissprot - O43763
swissprot - F1T0F2
Ensembl - ENSG00000115297
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Tlx2ENSMUSG00000068327Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TLX3 / O43711 / T cell leukemia homeobox 3ENSG0000016443862
TLX1 / P31314 / T cell leukemia homeobox 1ENSG0000010780761
BARHL2 / Q9NY43 / BarH like homeobox 2ENSG0000014303226
BARHL1 / Q9BZE3 / BarH like homeobox 1ENSG0000012549224
LBX2 / Q6XYB7 / ladybird homeobox 2ENSG0000017952823
NKX6-2 / Q9C056 / NK6 homeobox 2ENSG0000014882620
HLX / Q14774 / H2.0 like homeoboxENSG0000013663020
NKX6-1 / P78426 / NK6 homeobox 1ENSG0000016362320
HHEX / Q03014 / hematopoietically expressed homeoboxENSG0000015280420
BSX / Q3C1V8 / brain specific homeoboxENSG0000018890919
LBX1 / P52954 / ladybird homeobox 1ENSG0000013813619
BARX2 / Q9UMQ3 / BARX homeobox 2ENSG0000004303918
BARX1 / Q9HBU1 / BARX homeobox 1ENSG0000013166818
DBX1 / A6NMT0 / developing brain homeobox 1ENSG0000010985117
DBX2 / Q6ZNG2 / developing brain homeobox 2ENSG0000018561016
A6NJ46 / NKX6-3 / NK6 homeobox 3ENSG000001650666


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001707 mesoderm formation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048484 enteric nervous system development IEA
 biological_processGO:0050774 negative regulation of dendrite morphogenesis IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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