ENSG00000136630


Homo sapiens

Features
Gene ID: ENSG00000136630
  
Biological name :HLX
  
Synonyms : H2.0 like homeobox / HLX / Q14774
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q41
Gene start: 220879400
Gene end: 220885059
  
Corresponding Affymetrix probe sets: 214438_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000355870
Ensembl peptide - ENSP00000408248
NCBI entrez gene - 3142     See in Manteia.
OMIM - 142995
RefSeq - NM_021958
RefSeq Peptide - NP_068777
swissprot - Q14774
swissprot - F8VWZ5
Ensembl - ENSG00000136630
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hlx1ENSDARG00000009134Danio rerio
 HLXENSGALG00000037257Gallus gallus
 HlxENSMUSG00000039377Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DBX1 / A6NMT0 / developing brain homeobox 1ENSG0000010985122
DBX2 / Q6ZNG2 / developing brain homeobox 2ENSG0000018561020
NKX6-1 / P78426 / NK6 homeobox 1ENSG0000016362317
NKX6-2 / Q9C056 / NK6 homeobox 2ENSG0000014882615
BARHL2 / Q9NY43 / BarH like homeobox 2ENSG0000014303214
BARX2 / Q9UMQ3 / BARX homeobox 2ENSG0000004303914
HHEX / Q03014 / hematopoietically expressed homeoboxENSG0000015280414
LBX1 / P52954 / ladybird homeobox 1ENSG0000013813614
BSX / Q3C1V8 / brain specific homeoboxENSG0000018890913
BARX1 / Q9HBU1 / BARX homeobox 1ENSG0000013166813
TLX3 / O43711 / T cell leukemia homeobox 3ENSG0000016443812
TLX2 / O43763 / T cell leukemia homeobox 2ENSG0000011529712
BARHL1 / Q9BZE3 / BarH like homeobox 1ENSG0000012549212
TLX1 / P31314 / T cell leukemia homeobox 1ENSG0000010780711
LBX2 / Q6XYB7 / ladybird homeobox 2ENSG0000017952810
A6NJ46 / NKX6-3 / NK6 homeobox 3ENSG000001650666


Protein motifs (from Interpro)
Interpro ID Name
 IPR000047  Helix-turn-helix motif
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR020479  Homeobox domain, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0007519 skeletal muscle tissue development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045627 positive regulation of T-helper 1 cell differentiation IEA
 biological_processGO:0045629 negative regulation of T-helper 2 cell differentiation IEA
 biological_processGO:0046622 positive regulation of organ growth IEA
 biological_processGO:0048484 enteric nervous system development IEA
 biological_processGO:0048513 animal organ development IEA
 biological_processGO:0048557 embryonic digestive tract morphogenesis IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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