ENSG00000070423


Homo sapiens

Features
Gene ID: ENSG00000070423
  
Biological name :RNF126
  
Synonyms : Q9BV68 / ring finger protein 126 / RNF126
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.3
Gene start: 647526
Gene end: 663277
  
Corresponding Affymetrix probe sets: 205748_s_at (Human Genome U133 Plus 2.0 Array)   215031_x_at (Human Genome U133 Plus 2.0 Array)   223332_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000475833
Ensembl peptide - ENSP00000292363
Ensembl peptide - ENSP00000464945
NCBI entrez gene - 55658     See in Manteia.
OMIM - 615177
RefSeq - XM_005259594
RefSeq - NM_194460
RefSeq Peptide - NP_919442
swissprot - A0A024R206
swissprot - Q9BV68
swissprot - U3KQF4
swissprot - K7EIY6
Ensembl - ENSG00000070423
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnf126ENSDARG00000104076Danio rerio
 RNF126ENSGALG00000042948Gallus gallus
 Q91YL2ENSMUSG00000035890Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9Y4L5 / RNF115 / ring finger protein 115ENSG0000026549146
PJA2 / O43164 / praja ring finger ubiquitin ligase 2ENSG0000019896126
PJA1 / Q8NG27 / praja ring finger ubiquitin ligase 1ENSG0000018119125
Q9P0P0 / RNF181 / ring finger protein 181ENSG0000016889414


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IBA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0006513 protein monoubiquitination IDA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway IMP
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0042147 retrograde transport, endosome to Golgi IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
 biological_processGO:0070534 protein K63-linked ubiquitination ISS
 biological_processGO:0070936 protein K48-linked ubiquitination ISS
 biological_processGO:0071629 cytoplasm protein quality control by the ubiquitin-proteasome system IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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