ENSG00000090060


Homo sapiens

Features
Gene ID: ENSG00000090060
  
Biological name :PAPOLA
  
Synonyms : P51003 / PAPOLA / poly(A) polymerase alpha
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q32.2
Gene start: 96501433
Gene end: 96567111
  
Corresponding Affymetrix probe sets: 209388_at (Human Genome U133 Plus 2.0 Array)   212718_at (Human Genome U133 Plus 2.0 Array)   212720_at (Human Genome U133 Plus 2.0 Array)   215374_at (Human Genome U133 Plus 2.0 Array)   222035_s_at (Human Genome U133 Plus 2.0 Array)   228569_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000451600
Ensembl peptide - ENSP00000451267
Ensembl peptide - ENSP00000451757
Ensembl peptide - ENSP00000452578
Ensembl peptide - ENSP00000216277
Ensembl peptide - ENSP00000376716
Ensembl peptide - ENSP00000450437
Ensembl peptide - ENSP00000450534
Ensembl peptide - ENSP00000450564
Ensembl peptide - ENSP00000450812
NCBI entrez gene - 10914     See in Manteia.
OMIM - 605553
RefSeq - XM_017020936
RefSeq - NM_001252006
RefSeq - NM_001252007
RefSeq - NM_001293627
RefSeq - NM_001293628
RefSeq - NM_001293632
RefSeq - NM_032632
RefSeq - XM_005267281
RefSeq - XM_005267282
RefSeq - XM_017020935
RefSeq Peptide - NP_001280557
RefSeq Peptide - NP_001280561
RefSeq Peptide - NP_116021
RefSeq Peptide - NP_001238935
RefSeq Peptide - NP_001238936
RefSeq Peptide - NP_001280556
swissprot - H0YJZ9
swissprot - A0A0C4DGK1
swissprot - G3V2A0
swissprot - G3V3I9
swissprot - G3V457
swissprot - G3XAH6
swissprot - H0YJ00
swissprot - P51003
swissprot - A0A024R6M3
swissprot - H0YJL4
Ensembl - ENSG00000090060
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 papolaENSDARG00000009585Danio rerio
 PAPOLAENSGALG00000033099Gallus gallus
 PapolaENSMUSG00000021111Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PAPOLB / Q9NRJ5 / poly(A) polymerase betaENSG0000021882372
PAPOLG / Q9BWT3 / poly(A) polymerase gammaENSG0000011542157


Protein motifs (from Interpro)
Interpro ID Name
 IPR002934  Polymerase, nucleotidyl transferase domain
 IPR007010  Poly(A) polymerase, RNA-binding domain
 IPR007012  Poly(A) polymerase, central domain
 IPR011068  Nucleotidyltransferase, class I-like, C-terminal
 IPR014492  Poly(A) polymerase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome TAS
 biological_processGO:0006369 termination of RNA polymerase II transcription TAS
 biological_processGO:0006378 mRNA polyadenylation IDA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0031123 RNA 3"-end processing IEA
 biological_processGO:0031124 mRNA 3"-end processing TAS
 biological_processGO:0031440 regulation of mRNA 3"-end processing IDA
 biological_processGO:0043631 RNA polyadenylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding ISS
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004652 polynucleotide adenylyltransferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0030145 manganese ion binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Cleavage of Growing Transcript in the Termination Region
mRNA Splicing - Major Pathway
mRNA 3-end processing
Processing of Intronless Pre-mRNAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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