ENSG00000095637


Homo sapiens

Features
Gene ID: ENSG00000095637
  
Biological name :SORBS1
  
Synonyms : Q9BX66 / sorbin and SH3 domain containing 1 / SORBS1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q24.1
Gene start: 95311771
Gene end: 95561414
  
Corresponding Affymetrix probe sets: 211705_s_at (Human Genome U133 Plus 2.0 Array)   211819_s_at (Human Genome U133 Plus 2.0 Array)   218087_s_at (Human Genome U133 Plus 2.0 Array)   222513_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000475901
Ensembl peptide - ENSP00000474932
Ensembl peptide - ENSP00000489022
Ensembl peptide - ENSP00000277982
Ensembl peptide - ENSP00000277984
Ensembl peptide - ENSP00000302556
Ensembl peptide - ENSP00000355136
Ensembl peptide - ENSP00000360271
Ensembl peptide - ENSP00000360272
Ensembl peptide - ENSP00000360283
Ensembl peptide - ENSP00000360285
Ensembl peptide - ENSP00000360291
Ensembl peptide - ENSP00000360292
Ensembl peptide - ENSP00000360293
Ensembl peptide - ENSP00000360295
Ensembl peptide - ENSP00000473813
NCBI entrez gene - 10580     See in Manteia.
OMIM - 605264
RefSeq - XM_017015540
RefSeq - NM_001034954
RefSeq - NM_001034955
RefSeq - NM_001034956
RefSeq - NM_001034957
RefSeq - NM_001290294
RefSeq - NM_001290295
RefSeq - NM_001290296
RefSeq - NM_001290297
RefSeq - NM_001290298
RefSeq - NM_006434
RefSeq - NM_015385
RefSeq - NM_024991
RefSeq - XM_017015523
RefSeq - XM_017015524
RefSeq - XM_017015525
RefSeq - XM_017015526
RefSeq - XM_017015527
RefSeq - XM_017015528
RefSeq - XM_017015529
RefSeq - XM_017015530
RefSeq - XM_017015531
RefSeq - XM_017015532
RefSeq - XM_017015533
RefSeq - XM_017015534
RefSeq - XM_017015535
RefSeq - XM_017015536
RefSeq - XM_017015537
RefSeq - XM_017015538
RefSeq - XM_017015539
RefSeq - XM_006717589
RefSeq - XM_006717593
RefSeq - XM_011539140
RefSeq - XM_011539150
RefSeq - XM_011539155
RefSeq - XM_011539167
RefSeq - XM_017015500
RefSeq - XM_017015501
RefSeq - XM_017015502
RefSeq - XM_017015503
RefSeq - XM_017015504
RefSeq - XM_017015505
RefSeq - XM_017015506
RefSeq - XM_017015507
RefSeq - XM_017015508
RefSeq - XM_017015509
RefSeq - XM_017015510
RefSeq - XM_017015511
RefSeq - XM_017015512
RefSeq - XM_017015513
RefSeq - XM_017015514
RefSeq - XM_017015515
RefSeq - XM_017015516
RefSeq - XM_017015517
RefSeq - XM_017015518
RefSeq - XM_017015519
RefSeq - XM_017015520
RefSeq - XM_017015521
RefSeq - XM_017015522
RefSeq Peptide - NP_001030126
RefSeq Peptide - NP_001030127
RefSeq Peptide - NP_001030128
RefSeq Peptide - NP_001030129
RefSeq Peptide - NP_001277223
RefSeq Peptide - NP_001277224
RefSeq Peptide - NP_001277225
RefSeq Peptide - NP_001277226
RefSeq Peptide - NP_001277227
RefSeq Peptide - NP_006425
RefSeq Peptide - NP_056200
RefSeq Peptide - NP_079267
swissprot - Q5T925
swissprot - Q9BX66
swissprot - S4R303
swissprot - S4R406
swissprot - A0A0U1RQI5
Ensembl - ENSG00000095637
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sorbs1ENSDARG00000103435Danio rerio
 SORBS1ENSGALG00000038722Gallus gallus
 Sorbs1ENSMUSG00000025006Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O94875 / SORBS2 / sorbin and SH3 domain containing 2ENSG0000015455622
O60504 / SORBS3 / sorbin and SH3 domain containing 3ENSG0000012089620
Q7Z6J0 / SH3RF1 / SH3 domain containing ring finger 1ENSG0000015444710
Q5HYK7 / SH3D19 / SH3 domain containing 19ENSG000001096869
Q8TEJ3 / SH3RF3 / SH3 domain containing ring finger 3ENSG000001729859
Q8TEC5 / SH3RF2 / SH3 domain containing ring finger 2ENSG000001564638


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR003127  SoHo domain
 IPR028506  Sorbin and SH3 domain-containing protein
 IPR035606  c-Cbl associated protein, SH3 domain
 IPR035610  c-Cbl associated protein, SH3 domain 1
 IPR035611  c-Cbl associated protein, SH3 domain 2
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006936 muscle contraction TAS
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007160 cell-matrix adhesion TAS
 biological_processGO:0008286 insulin receptor signaling pathway ISS
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0032869 cellular response to insulin stimulus ISS
 biological_processGO:0043149 stress fiber assembly ISS
 biological_processGO:0045725 positive regulation of glycogen biosynthetic process ISS
 biological_processGO:0046326 positive regulation of glucose import ISS
 biological_processGO:0046889 positive regulation of lipid biosynthetic process ISS
 biological_processGO:0048041 focal adhesion assembly ISS
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane ISS
 biological_processGO:2001275 positive regulation of glucose import in response to insulin stimulus ISS
 cellular_componentGO:0001725 stress fiber ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005899 insulin receptor complex IDA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0005913 cell-cell adherens junction TAS
 cellular_componentGO:0005915 zonula adherens TAS
 cellular_componentGO:0005924 cell-substrate adherens junction ISS
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045121 membrane raft ISS
 molecular_functionGO:0003779 actin binding TAS
 molecular_functionGO:0005070 SH3/SH2 adaptor activity ISS
 molecular_functionGO:0005158 insulin receptor binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008092 cytoskeletal protein binding TAS


Pathways (from Reactome)
Pathway description
Smooth Muscle Contraction


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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contact: otassy@igbmc.fr