ENSG00000154447


Homo sapiens

Features
Gene ID: ENSG00000154447
  
Biological name :SH3RF1
  
Synonyms : Q7Z6J0 / SH3 domain containing ring finger 1 / SH3RF1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q33
Gene start: 169094256
Gene end: 169271105
  
Corresponding Affymetrix probe sets: 225589_at (Human Genome U133 Plus 2.0 Array)   225590_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000421714
Ensembl peptide - ENSP00000427585
Ensembl peptide - ENSP00000426418
Ensembl peptide - ENSP00000284637
NCBI entrez gene - 57630     See in Manteia.
RefSeq - NM_020870
RefSeq Peptide - NP_065921
swissprot - D6RHX5
swissprot - D6RAL3
swissprot - H0YA90
swissprot - Q7Z6J0
Ensembl - ENSG00000154447
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sh3rf1ENSDARG00000070470Danio rerio
 SH3RF1ENSGALG00000009692Gallus gallus
 Sh3rf1ENSMUSG00000031642Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8TEJ3 / SH3RF3 / SH3 domain containing ring finger 3ENSG0000017298548
Q8TEC5 / SH3RF2 / SH3 domain containing ring finger 2ENSG0000015646328
Q9BX66 / SORBS1 / sorbin and SH3 domain containing 1ENSG0000009563715
O60504 / SORBS3 / sorbin and SH3 domain containing 3ENSG0000012089613
O94875 / SORBS2 / sorbin and SH3 domain containing 2ENSG0000015455612
Q5HYK7 / SH3D19 / SH3 domain containing 19ENSG0000010968610


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR018957  Zinc finger, C3HC4 RING-type
 IPR028502  E3 ubiquitin-protein ligase SH3RF1
 IPR035795  E3 ubiquitin-protein ligase SH3RF1, second SH3 domain
 IPR035816  SH3RF1/SH3RF3, fourth SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0046328 regulation of JNK cascade IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr