ENSG00000120896


Homo sapiens

Features
Gene ID: ENSG00000120896
  
Biological name :SORBS3
  
Synonyms : O60504 / sorbin and SH3 domain containing 3 / SORBS3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p21.3
Gene start: 22544986
Gene end: 22575788
  
Corresponding Affymetrix probe sets: 207788_s_at (Human Genome U133 Plus 2.0 Array)   209253_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000429479
Ensembl peptide - ENSP00000428678
Ensembl peptide - ENSP00000429723
Ensembl peptide - ENSP00000431128
Ensembl peptide - ENSP00000429764
Ensembl peptide - ENSP00000240123
Ensembl peptide - ENSP00000428102
Ensembl peptide - ENSP00000428327
NCBI entrez gene - 10174     See in Manteia.
OMIM - 610795
RefSeq - XM_017012946
RefSeq - NM_001018003
RefSeq - NM_005775
RefSeq - XM_005273371
RefSeq - XM_006716266
RefSeq - XM_006716268
RefSeq - XM_017012944
RefSeq - XM_017012945
RefSeq Peptide - NP_001018003
RefSeq Peptide - NP_005766
swissprot - E7EQH0
swissprot - E5RJP2
swissprot - H0YAU6
swissprot - H0YAZ3
swissprot - H0YB51
swissprot - O60504
swissprot - E5RIA0
Ensembl - ENSG00000120896
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sorbs3ENSDARG00000037476Danio rerio
 Q9R1Z8ENSMUSG00000022091Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9BX66 / SORBS1 / sorbin and SH3 domain containing 1ENSG0000009563739
O94875 / SORBS2 / sorbin and SH3 domain containing 2ENSG0000015455629
Q7Z6J0 / SH3RF1 / SH3 domain containing ring finger 1ENSG0000015444717
Q8TEJ3 / SH3RF3 / SH3 domain containing ring finger 3ENSG0000017298516
Q5HYK7 / SH3D19 / SH3 domain containing 19ENSG0000010968614
Q8TEC5 / SH3RF2 / SH3 domain containing ring finger 2ENSG0000015646313


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR003127  SoHo domain
 IPR028510  Vinexin
 IPR035607  Vinexin, SH3 domain 3
 IPR035608  Vinexin, SH3 domain 2
 IPR035609  Vinexin, SH3 domain 1
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006936 muscle contraction TAS
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0031589 cell-substrate adhesion IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0051495 positive regulation of cytoskeleton organization NAS
 biological_processGO:0051496 positive regulation of stress fiber assembly IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0017166 vinculin binding IPI


Pathways (from Reactome)
Pathway description
Smooth Muscle Contraction


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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