ENSMUSG00000025006


Mus musculus

Features
Gene ID: ENSMUSG00000025006
  
Biological name :Sorbs1
  
Synonyms : sorbin and SH3 domain containing 1 / Sorbs1
  
Possible biological names infered from orthology : Q9BX66
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C3
Gene start: 40294753
Gene end: 40513779
  
Corresponding Affymetrix probe sets: 10467425 (MoGene1.0st)   1417358_s_at (Mouse Genome 430 2.0 Array)   1425826_a_at (Mouse Genome 430 2.0 Array)   1428471_at (Mouse Genome 430 2.0 Array)   1436737_a_at (Mouse Genome 430 2.0 Array)   1440311_at (Mouse Genome 430 2.0 Array)   1455967_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126460
Ensembl peptide - ENSMUSP00000125768
Ensembl peptide - ENSMUSP00000152957
Ensembl peptide - ENSMUSP00000153489
Ensembl peptide - ENSMUSP00000153450
Ensembl peptide - ENSMUSP00000153336
Ensembl peptide - ENSMUSP00000153313
Ensembl peptide - ENSMUSP00000153257
Ensembl peptide - ENSMUSP00000153097
Ensembl peptide - ENSMUSP00000153080
Ensembl peptide - ENSMUSP00000153009
Ensembl peptide - ENSMUSP00000097065
Ensembl peptide - ENSMUSP00000097066
NCBI entrez gene - 20411     See in Manteia.
MGI - MGI:700014
RefSeq - XM_017318097
RefSeq - XM_011247191
RefSeq - XM_011247192
RefSeq - XM_011247193
RefSeq - XM_011247195
RefSeq - XM_011247197
RefSeq - XM_011247198
RefSeq - XM_011247199
RefSeq - XM_017318089
RefSeq - XM_017318090
RefSeq - XM_017318091
RefSeq - XM_017318092
RefSeq - XM_017318093
RefSeq - XM_017318094
RefSeq - XM_017318095
RefSeq - XM_017318096
RefSeq - NM_001034962
RefSeq - NM_001034963
RefSeq - NM_001034964
RefSeq - NM_009166
RefSeq - NM_178362
RefSeq - XM_006526789
RefSeq - XM_006526790
RefSeq - XM_006526792
RefSeq - XM_006526793
RefSeq - XM_006526795
RefSeq - XM_006526798
RefSeq - XM_006526799
RefSeq - XM_006526800
RefSeq - XM_006526801
RefSeq - XM_006526804
RefSeq - XM_006526806
RefSeq - XM_006526810
RefSeq - XM_006526813
RefSeq - XM_011247172
RefSeq - XM_011247173
RefSeq - XM_011247174
RefSeq - XM_011247175
RefSeq - XM_011247176
RefSeq - XM_011247177
RefSeq - XM_011247178
RefSeq - XM_011247179
RefSeq - XM_011247180
RefSeq - XM_011247181
RefSeq - XM_011247183
RefSeq - XM_011247185
RefSeq - XM_011247186
RefSeq - XM_011247189
RefSeq - XM_011247190
RefSeq Peptide - NP_001030136
RefSeq Peptide - NP_033192
RefSeq Peptide - NP_848139
RefSeq Peptide - NP_001030135
RefSeq Peptide - NP_001030134
swissprot - A0A286YDJ3
swissprot - A0A286YD34
swissprot - E9QNA7
swissprot - A0A286YCN8
swissprot - A0A286YCI8
swissprot - A0A286YCQ0
swissprot - E9Q6A3
swissprot - E9PYX6
swissprot - D3Z5J3
swissprot - A0A286YDN0
Ensembl - ENSMUSG00000025006
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sorbs1ENSDARG00000103435Danio rerio
 SORBS1ENSGALG00000038722Gallus gallus
 Q9BX66ENSG00000095637Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3UTJ2 / Sorbs2 / sorbin and SH3 domain containing 2 / O94875*ENSMUSG0000003162630
Q9R1Z8 / Sorbs3 / sorbin and SH3 domain containing 3 / O60504*ENSMUSG0000002209125
Q91X43 / Sh3d19 / SH3 domain-containing protein 19 / Q5HYK7* / SH3 domain containing 19*ENSMUSG0000002808211
Sh3rf1 / SH3 domain containing ring finger 1 / Q7Z6J0*ENSMUSG0000003164210
Q8C120 / Sh3rf3 / SH3 domain-containing RING finger protein 3 / Q8TEJ3* / SH3 domain containing ring finger 3*ENSMUSG0000003799010
Q8BZT2 / Sh3rf2 / Putative E3 ubiquitin-protein ligase SH3RF2 / Q8TEC5* / SH3 domain containing ring finger 2*ENSMUSG000000577198


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR003127  SoHo domain
 IPR028506  Sorbin and SH3 domain-containing protein
 IPR028510  Vinexin
 IPR035606  c-Cbl associated protein, SH3 domain
 IPR035610  c-Cbl associated protein, SH3 domain 1
 IPR035611  c-Cbl associated protein, SH3 domain 2
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007155 cell adhesion IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005899 insulin receptor complex IEA
 cellular_componentGO:0005925 focal adhesion IEA
 molecular_functionGO:0005158 insulin receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Smooth Muscle Contraction


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001560 abnormal circulating insulin level "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005670 abnormal white fat physiology "functional aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
Show

Allelic Composition: Aqp2tm1(cre)Blyg/Aqp2tm1(cre)Blyg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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