ENSMUSG00000031626


Mus musculus

Features
Gene ID: ENSMUSG00000031626
  
Biological name :Sorbs2
  
Synonyms : Q3UTJ2 / sorbin and SH3 domain containing 2 / Sorbs2
  
Possible biological names infered from orthology : O94875
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B1.1
Gene start: 45507788
Gene end: 45827906
  
Corresponding Affymetrix probe sets: 10571567 (MoGene1.0st)   1431192_at (Mouse Genome 430 2.0 Array)   1437197_at (Mouse Genome 430 2.0 Array)   1441624_at (Mouse Genome 430 2.0 Array)   1446744_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117544
Ensembl peptide - ENSMUSP00000116768
Ensembl peptide - ENSMUSP00000118160
Ensembl peptide - ENSMUSP00000148072
Ensembl peptide - ENSMUSP00000147573
Ensembl peptide - ENSMUSP00000147462
Ensembl peptide - ENSMUSP00000128000
Ensembl peptide - ENSMUSP00000123503
Ensembl peptide - ENSMUSP00000123250
Ensembl peptide - ENSMUSP00000123195
Ensembl peptide - ENSMUSP00000122820
Ensembl peptide - ENSMUSP00000121619
Ensembl peptide - ENSMUSP00000121235
Ensembl peptide - ENSMUSP00000121073
Ensembl peptide - ENSMUSP00000120487
Ensembl peptide - ENSMUSP00000119539
Ensembl peptide - ENSMUSP00000119380
Ensembl peptide - ENSMUSP00000118562
Ensembl peptide - ENSMUSP00000118353
Ensembl peptide - ENSMUSP00000067641
Ensembl peptide - ENSMUSP00000070720
Ensembl peptide - ENSMUSP00000114158
Ensembl peptide - ENSMUSP00000114286
Ensembl peptide - ENSMUSP00000114951
Ensembl peptide - ENSMUSP00000115842
Ensembl peptide - ENSMUSP00000116536
NCBI entrez gene - 234214     See in Manteia.
MGI - MGI:1924574
RefSeq - XM_011242204
RefSeq - XM_006509387
RefSeq - XM_011242198
RefSeq - XM_011242199
RefSeq - XM_011242200
RefSeq - XM_011242201
RefSeq - XM_011242202
RefSeq - XM_011242205
RefSeq - XM_011242206
RefSeq - XM_011242207
RefSeq - XM_011242208
RefSeq - XM_011242209
RefSeq - XM_011242210
RefSeq - XM_011242212
RefSeq - XM_017312683
RefSeq - XM_017312684
RefSeq - XM_017312685
RefSeq - XM_017312686
RefSeq - XM_017312687
RefSeq - XM_017312688
RefSeq - XM_017312689
RefSeq - XM_017312690
RefSeq - XM_017312691
RefSeq - XM_017312692
RefSeq - XM_017312693
RefSeq - XM_017312694
RefSeq - XM_017312695
RefSeq - XM_017312696
RefSeq - NM_001205219
RefSeq - NM_001310707
RefSeq - NM_001310708
RefSeq - NM_172752
RefSeq - XM_006509375
RefSeq - XM_006509385
RefSeq - XM_006509386
RefSeq Peptide - NP_766340
RefSeq Peptide - NP_001192148
RefSeq Peptide - NP_001297636
RefSeq Peptide - NP_001297637
swissprot - D3Z0E9
swissprot - D3Z080
swissprot - D3YY43
swissprot - D3YUT0
swissprot - D3YTN2
swissprot - B9EKP8
swissprot - B7ZWM6
swissprot - B2RXQ9
swissprot - A0A1B0GSU3
swissprot - D3Z4W6
swissprot - A0A1B0GRC3
swissprot - A0A0R4J1X5
swissprot - F6V513
swissprot - F6ZWT0
swissprot - F7BEU1
swissprot - A0A0R4J1W0
swissprot - Q3UTJ2
swissprot - Z4YJR7
swissprot - A0A0R4J1T1
swissprot - A0A1B0GRL6
swissprot - D3Z2C7
swissprot - D3Z203
swissprot - D3Z0N2
Ensembl - ENSMUSG00000031626
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sorbs2aENSDARG00000003046Danio rerio
 sorbs2bENSDARG00000061603Danio rerio
 SORBS2ENSGALG00000013427Gallus gallus
 O94875ENSG00000154556Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sorbs1 / sorbin and SH3 domain containing 1 / Q9BX66*ENSMUSG0000002500623
Q9R1Z8 / Sorbs3 / sorbin and SH3 domain containing 3 / O60504*ENSMUSG0000002209116
Q91X43 / Sh3d19 / SH3 domain-containing protein 19 / Q5HYK7* / SH3 domain containing 19*ENSMUSG0000002808210
Sh3rf1 / SH3 domain containing ring finger 1 / Q7Z6J0*ENSMUSG000000316429
Q8C120 / Sh3rf3 / SH3 domain-containing RING finger protein 3 / Q8TEJ3* / SH3 domain containing ring finger 3*ENSMUSG000000379909
Q8BZT2 / Sh3rf2 / Putative E3 ubiquitin-protein ligase SH3RF2 / Q8TEC5* / SH3 domain containing ring finger 2*ENSMUSG000000577197


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR003127  SoHo domain
 IPR013087  Zinc finger C2H2-type
 IPR028506  Sorbin and SH3 domain-containing protein
 IPR036028  SH3-like domain superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007219 Notch signaling pathway IDA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Sprr3tm1.1Ppy/Sprr3tm1.1Ppy
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Sprr3tm1.1Ppy/Sprr3tm1.1Ppy
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J * SJL

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Sprr3tm1.1Ppy/Sprr3tm1.1Ppy
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J * SJL

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Sprr3tm1.1Ppy/Sprr3tm1.1Ppy
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J * SJL

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Sprr3tm1.1Ppy/Sprr3tm1.1Ppy
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J * SJL

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Sprr3tm1.1Ppy/Sprr3tm1.1Ppy
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J * SJL

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Sprr3tm1.1Ppy/Sprr3tm1.1Ppy
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J * SJL

 MP:0010511 shortened PR interval "decrease in the length of time between the beginning of atrial depolarization and the beginning of ventricular depolarization, measured by the interval from the beginning of the P wave to the beginning of the QRS complex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0010571 shortened ST segment "reduction in the length of time between the end of S-wave and the beginning of T-wave; reflects the amount of time the ventricles remain electrically depolarized" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Sprr3tm1.1Ppy/Sprr3tm1.1Ppy
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J * SJL

 MP:0011954 shortened PQ interval "decrease in the length of time between the beginning of atrial depolarization and the end of atrial repolarization (or recovery), measured by the interval from the beginning of the P wave to the end of the Q wave" [MPD:Molly]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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