ENSG00000103202


Homo sapiens

Features
Gene ID: ENSG00000103202
  
Biological name :NME4
  
Synonyms : NME4 / NME/NM23 nucleoside diphosphate kinase 4 / O00746
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p13.3
Gene start: 396725
Gene end: 410367
  
Corresponding Affymetrix probe sets: 212739_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000479681
Ensembl peptide - ENSP00000479996
Ensembl peptide - ENSP00000406317
Ensembl peptide - ENSP00000412039
Ensembl peptide - ENSP00000219479
Ensembl peptide - ENSP00000372398
Ensembl peptide - ENSP00000380834
Ensembl peptide - ENSP00000389048
Ensembl peptide - ENSP00000395605
Ensembl peptide - ENSP00000405925
NCBI entrez gene - 4833     See in Manteia.
OMIM - 601818
RefSeq - NM_001286435
RefSeq - NM_001286438
RefSeq - NM_001286439
RefSeq - NM_001286440
RefSeq - NM_005009
RefSeq - NM_001286433
RefSeq - NM_001286436
RefSeq Peptide - NP_001273364
RefSeq Peptide - NP_001273367
RefSeq Peptide - NP_001273368
RefSeq Peptide - NP_001273369
RefSeq Peptide - NP_005000
RefSeq Peptide - NP_001273362
RefSeq Peptide - NP_001273365
swissprot - Q4TT34
swissprot - A0A087WVT9
swissprot - A2IDC9
swissprot - F2Z297
swissprot - F2Z2X0
swissprot - H0Y6J0
swissprot - O00746
Ensembl - ENSG00000103202
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nme4ENSDARG00000088390Danio rerio
 NME4ENSGALG00000002688Gallus gallus
 Nme4ENSMUSG00000024177Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NME3 / Q13232 / NME/NM23 nucleoside diphosphate kinase 3ENSG0000010302448
NME1 / P15531 / NME/NM23 nucleoside diphosphate kinase 1ENSG0000023967247
NME1-NME2 / NME1-NME2 readthroughENSG0000001105244
NME2 / P22392 / NME/NM23 nucleoside diphosphate kinase 2ENSG0000024367844
NME7 / Q9Y5B8 / NME/NM23 family member 7ENSG0000014315623
NME6 / O75414 / NME/NM23 nucleoside diphosphate kinase 6ENSG0000017211323
NME5 / P56597 / NME/NM23 family member 5ENSG0000011298122
NME8 / Q8N427 / NME/NM23 family member 8ENSG0000008628820
NME9 / Q86XW9 / NME/NM23 family member 9ENSG0000018132210


Protein motifs (from Interpro)
Interpro ID Name
 IPR001564  Nucleoside diphosphate kinase
 IPR023005  Nucleoside diphosphate kinase, active site
 IPR034907  Nucleoside diphosphate kinase-like domain
 IPR036850  Nucleoside diphosphate kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006165 nucleoside diphosphate phosphorylation IEA
 biological_processGO:0006183 GTP biosynthetic process IEA
 biological_processGO:0006228 UTP biosynthetic process IEA
 biological_processGO:0006241 CTP biosynthetic process IEA
 biological_processGO:0006869 lipid transport IDA
 biological_processGO:0009116 nucleoside metabolic process TAS
 biological_processGO:0009117 nucleotide metabolic process IEA
 biological_processGO:0015949 nucleobase-containing small molecule interconversion TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005743 mitochondrial inner membrane TAS
 cellular_componentGO:0005758 mitochondrial intermembrane space IDA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004550 nucleoside diphosphate kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1901612 cardiolipin binding IDA


Pathways (from Reactome)
Pathway description
Interconversion of nucleotide di- and triphosphates


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000103202 NME4 / O00746 / NME/NM23 nucleoside diphosphate kinase 4  / complex






 

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