ENSMUSG00000024177


Mus musculus

Features
Gene ID: ENSMUSG00000024177
  
Biological name :Nme4
  
Synonyms : Nme4 / Nucleoside diphosphate kinase, mitochondrial / Q9WV84
  
Possible biological names infered from orthology : NME/NM23 nucleoside diphosphate kinase 4 / O00746
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 26091734
Gene end: 26095508
  
Corresponding Affymetrix probe sets: 10449236 (MoGene1.0st)   1416798_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025007
NCBI entrez gene - 56520     See in Manteia.
MGI - MGI:1931148
RefSeq - NM_019731
RefSeq - XM_006524677
RefSeq Peptide - NP_062705
swissprot - Q9WV84
Ensembl - ENSMUSG00000024177
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nme4ENSDARG00000088390Danio rerio
 NME4ENSGALG00000002688Gallus gallus
 NME4ENSG00000103202Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nme3 / Q9WV85 / Nucleoside diphosphate kinase 3 / Q13232* / NME/NM23 nucleoside diphosphate kinase 3*ENSMUSG0000007343551
Nme1 / P15532 / Nucleoside diphosphate kinase A / P15531* / NME/NM23 nucleoside diphosphate kinase 1*ENSMUSG0000003760145
Nme2 / Q01768 / NME/NM23 nucleoside diphosphate kinase 2 / P22392* / NME1-NME2* / NME1-NME2 readthrough*ENSMUSG0000002085744
Gm20390 / NME2* / P22392* / NME1-NME2* / NME1-NME2 readthrough* / NME/NM23 nucleoside diphosphate kinase 2*ENSMUSG0000009122844
Nme7 / NME/NM23 family member 7 / Q9Y5B8*ENSMUSG0000002657524
Nme6 / O88425 / Nucleoside diphosphate kinase 6 / O75414* / NME/NM23 nucleoside diphosphate kinase 6*ENSMUSG0000003247823
Nme5 / Q99MH5 / Nucleoside diphosphate kinase homolog 5 / P56597* / NME/NM23 family member 5*ENSMUSG0000003598421
Nme8 / Q715T0 / Thioredoxin domain-containing protein 3 / Q8N427* / NME/NM23 family member 8*ENSMUSG0000004113817
Nme9 / NME/NM23 family member 9 / Q86XW9*ENSMUSG0000004624211


Protein motifs (from Interpro)
Interpro ID Name
 IPR001564  Nucleoside diphosphate kinase
 IPR023005  Nucleoside diphosphate kinase, active site
 IPR034907  Nucleoside diphosphate kinase-like domain
 IPR036850  Nucleoside diphosphate kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006165 nucleoside diphosphate phosphorylation IEA
 biological_processGO:0006183 GTP biosynthetic process IEA
 biological_processGO:0006228 UTP biosynthetic process IEA
 biological_processGO:0006241 CTP biosynthetic process IEA
 biological_processGO:0006869 lipid transport ISO
 biological_processGO:0009117 nucleotide metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005758 mitochondrial intermembrane space ISO
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004550 nucleoside diphosphate kinase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1901612 cardiolipin binding IEA


Pathways (from Reactome)
Pathway description
Interconversion of nucleotide di- and triphosphates


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0013430 increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number "increase in the number of the CD4+, CD25+ alpha-beta regulatory T cells with a CD44+ CD62L- memory phenotype" [IMPC:Saran]
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Allelic Composition: Enhotm1.1Butl/Enho+
Genetic Background: B6.Cg-Enhotm1.1Butl

 MP:0013435 decreased CD8-positive, naive alpha-beta T cell number "reduction in the number of the naïve regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions with a CD44-low CD62L+ phenotype" [IMPC:Saran]
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Allelic Composition: Enhotm1.1Butl/Enho+
Genetic Background: B6.Cg-Enhotm1.1Butl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024177 Nme4 / Q9WV84 / Nucleoside diphosphate kinase, mitochondrial / O00746* / NME/NM23 nucleoside diphosphate kinase 4*  / complex






 

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