ENSMUSG00000026575


Mus musculus

Features
Gene ID: ENSMUSG00000026575
  
Biological name :Nme7
  
Synonyms : Nme7 / NME/NM23 family member 7
  
Possible biological names infered from orthology : Q9Y5B8
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H2.2
Gene start: 164304121
Gene end: 164437725
  
Corresponding Affymetrix probe sets: 10351277 (MoGene1.0st)   1418217_at (Mouse Genome 430 2.0 Array)   1438874_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000083192
Ensembl peptide - ENSMUSP00000141431
Ensembl peptide - ENSMUSP00000141771
Ensembl peptide - ENSMUSP00000141963
NCBI entrez gene - 171567     See in Manteia.
MGI - MGI:2449121
RefSeq - XM_006496693
RefSeq - NM_001293313
RefSeq - NM_138314
RefSeq - NM_178071
RefSeq - XM_006496692
RefSeq Peptide - NP_835172
RefSeq Peptide - NP_001280242
RefSeq Peptide - NP_612187
swissprot - Q3UMG6
swissprot - Q8BUH2
Ensembl - ENSMUSG00000026575
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nme7ENSDARG00000056193Danio rerio
 NME7ENSGALG00000015230Gallus gallus
 NME7ENSG00000143156Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nme8 / Q715T0 / Thioredoxin domain-containing protein 3 / Q8N427* / NME/NM23 family member 8*ENSMUSG0000004113822
Nme5 / Q99MH5 / Nucleoside diphosphate kinase homolog 5 / P56597* / NME/NM23 family member 5*ENSMUSG0000003598418
Nme6 / O88425 / Nucleoside diphosphate kinase 6 / O75414* / NME/NM23 nucleoside diphosphate kinase 6*ENSMUSG0000003247816
Nme9 / NME/NM23 family member 9 / Q86XW9*ENSMUSG0000004624212
Nme2 / Q01768 / NME/NM23 nucleoside diphosphate kinase 2 / P22392* / NME1-NME2* / NME1-NME2 readthrough*ENSMUSG0000002085711
Nme1 / P15532 / Nucleoside diphosphate kinase A / P15531* / NME/NM23 nucleoside diphosphate kinase 1*ENSMUSG0000003760111
Nme4 / Q9WV84 / Nucleoside diphosphate kinase, mitochondrial / O00746* / NME/NM23 nucleoside diphosphate kinase 4*ENSMUSG0000002417711
Gm20390 / NME2* / P22392* / NME1-NME2* / NME1-NME2 readthrough* / NME/NM23 nucleoside diphosphate kinase 2*ENSMUSG0000009122811
Nme3 / Q9WV85 / Nucleoside diphosphate kinase 3 / Q13232* / NME/NM23 nucleoside diphosphate kinase 3*ENSMUSG0000007343510


Protein motifs (from Interpro)
Interpro ID Name
 IPR001564  Nucleoside diphosphate kinase
 IPR006602  Uncharacterised domain DM10
 IPR010554  Domain of unknown function DUF1126
 IPR011410  Nucleoside diphosphate kinase 7
 IPR034907  Nucleoside diphosphate kinase-like domain
 IPR035525  NDPK7, first NDPk domain
 IPR036850  Nucleoside diphosphate kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006165 nucleoside diphosphate phosphorylation IEA
 biological_processGO:0006183 GTP biosynthetic process IEA
 biological_processGO:0006228 UTP biosynthetic process IEA
 biological_processGO:0006241 CTP biosynthetic process IEA
 cellular_componentGO:0005813 centrosome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004550 nucleoside diphosphate kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Recruitment of mitotic centrosome proteins and complexes
Recruitment of NuMA to mitotic centrosomes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000440 domed skull 
Show

Allelic Composition: Fmr1tm1Cgr/Fmr1tm1Cgr
Genetic Background: B6.129P2-Fmr1tm1Cgr

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
Show

Allelic Composition: Fmr1tm1Cgr/Fmr1tm1Cgr
Genetic Background: B6.129P2-Fmr1tm1Cgr

 MP:0000827 dilated third ventricle "enlarged narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fmr1tm1Cgr/Fmr1tm1Cgr
Genetic Background: B6.129P2-Fmr1tm1Cgr

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Fmr1tm1Cgr/Fmr1tm1Cgr
Genetic Background: B6.129P2-Fmr1tm1Cgr

 MP:0002766 situs inversus "lateral transposition of the viscera of the thorax and abdomen, sometimes incomplete" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fmr1tm1Cgr/Fmr1tm1Cgr
Genetic Background: B6.129P2-Fmr1tm1Cgr

 MP:0011055 abnormal respiratory motile cilium physiology "any functional anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract; may include alterations in ciliary beating pattern or frequency" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fmr1tm1Cgr/Fmr1tm1Cgr
Genetic Background: B6.129P2-Fmr1tm1Cgr

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Mthfd1tm2b(KOMP)Wtsi/Mthfd1tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mthfd1tm2b(KOMP)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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