ENSMUSG00000037601


Mus musculus

Features
Gene ID: ENSMUSG00000037601
  
Biological name :Nme1
  
Synonyms : Nme1 / Nucleoside diphosphate kinase A / P15532
  
Possible biological names infered from orthology : NME/NM23 nucleoside diphosphate kinase 1 / P15531
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 93956979
Gene end: 93968521
  
Corresponding Affymetrix probe sets: 10389865 (MoGene1.0st)   1424110_a_at (Mouse Genome 430 2.0 Array)   1435277_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021220
Ensembl peptide - ENSMUSP00000103475
Ensembl peptide - ENSMUSP00000117022
NCBI entrez gene - 18102     See in Manteia.
MGI - MGI:97355
RefSeq - NM_008704
RefSeq Peptide - NP_032730
swissprot - P15532
swissprot - Q5NC79
swissprot - Q5NC80
swissprot - Q5NC81
Ensembl - ENSMUSG00000037601
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nme2aENSDARG00000043820Danio rerio
 nme2b.1ENSDARG00000103791Danio rerio
 nme2b.2ENSDARG00000099420Danio rerio
 NME2ENSGALG00000002932Gallus gallus
 NME1ENSG00000239672Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm20390 / NME2* / P22392* / NME1-NME2* / NME1-NME2 readthrough* / NME/NM23 nucleoside diphosphate kinase 2*ENSMUSG0000009122889
Nme2 / Q01768 / NME/NM23 nucleoside diphosphate kinase 2 / P22392* / NME1-NME2* / NME1-NME2 readthrough*ENSMUSG0000002085788
Nme3 / Q9WV85 / Nucleoside diphosphate kinase 3 / Q13232* / NME/NM23 nucleoside diphosphate kinase 3*ENSMUSG0000007343563
Nme4 / Q9WV84 / Nucleoside diphosphate kinase, mitochondrial / O00746* / NME/NM23 nucleoside diphosphate kinase 4*ENSMUSG0000002417755
Nme7 / NME/NM23 family member 7 / Q9Y5B8*ENSMUSG0000002657528
Nme5 / Q99MH5 / Nucleoside diphosphate kinase homolog 5 / P56597* / NME/NM23 family member 5*ENSMUSG0000003598426
Nme6 / O88425 / Nucleoside diphosphate kinase 6 / O75414* / NME/NM23 nucleoside diphosphate kinase 6*ENSMUSG0000003247826
Nme8 / Q715T0 / Thioredoxin domain-containing protein 3 / Q8N427* / NME/NM23 family member 8*ENSMUSG0000004113823
Nme9 / NME/NM23 family member 9 / Q86XW9*ENSMUSG0000004624215


Protein motifs (from Interpro)
Interpro ID Name
 IPR001564  Nucleoside diphosphate kinase
 IPR023005  Nucleoside diphosphate kinase, active site
 IPR034907  Nucleoside diphosphate kinase-like domain
 IPR036850  Nucleoside diphosphate kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002762 negative regulation of myeloid leukocyte differentiation IEA
 biological_processGO:0006165 nucleoside diphosphate phosphorylation IEA
 biological_processGO:0006183 GTP biosynthetic process IEA
 biological_processGO:0006228 UTP biosynthetic process IEA
 biological_processGO:0006241 CTP biosynthetic process IEA
 biological_processGO:0006259 DNA metabolic process IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007595 lactation IMP
 biological_processGO:0009117 nucleotide metabolic process IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0014075 response to amine IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030879 mammary gland development IMP
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071398 cellular response to fatty acid IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005882 intermediate filament IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0004536 deoxyribonuclease activity IEA
 molecular_functionGO:0004550 nucleoside diphosphate kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019215 intermediate filament binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043015 gamma-tubulin binding IEA
 molecular_functionGO:0043024 ribosomal small subunit binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Interconversion of nucleotide di- and triphosphates


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nme1tm1Jyd/Nme1tm1Jyd
Genetic Background: 129-Nme1tm1Jyd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Abcb7tm1Mdf/Y,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: either: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Abcb7tm1Mdf or (involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA)

Allelic Composition: Nme1tm1Jyd/Nme1tm1Jyd
Genetic Background: B6.129-Nme1tm1Jyd

Allelic Composition: Nme1tm1Jyd/Nme1tm1Jyd
Genetic Background: 129-Nme1tm1Jyd

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
Show

Allelic Composition: Nme1tm1Jyd/Nme1tm1Jyd
Genetic Background: B6.129-Nme1tm1Jyd

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcb7tm1Mdf/Y,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: either: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Abcb7tm1Mdf or (involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA)

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcb7tm1Mdf/Y,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: either: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Abcb7tm1Mdf or (involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA)

Allelic Composition: Nme1tm1Jyd/Nme1tm1Jyd
Genetic Background: B6.129-Nme1tm1Jyd

 MP:0005517 decreased liver regeneration "less than the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abcb7tm1Mdf/Y,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: either: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Abcb7tm1Mdf or (involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA)

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Abcb7tm1Mdf/Y,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: either: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Abcb7tm1Mdf or (involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA)

Allelic Composition: Nme1tm1Jyd/Nme1tm1Jyd
Genetic Background: B6.129-Nme1tm1Jyd

Allelic Composition: Nme1tm1Jyd/Nme1tm1Jyd
Genetic Background: 129-Nme1tm1Jyd

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Abcb7tm1Mdf/Y,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: either: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Abcb7tm1Mdf or (involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000073435 Nme3 / Q9WV85 / Nucleoside diphosphate kinase 3 / Q13232* / NME/NM23 nucleoside diphosphate kinase 3*  / complex
 ENSMUSG00000037601 Nme1 / P15532 / Nucleoside diphosphate kinase A / P15531* / NME/NM23 nucleoside diphosphate kinase 1*  / complex
 ENSMUSG00000020857 Nme2 / Q01768 / NME/NM23 nucleoside diphosphate kinase 2 / P22392* / NME1-NME2* / NME1-NME2 readthrough*  / complex
 ENSMUSG00000091228 Gm20390 / NME2* / P22392* / NME1-NME2* / NME1-NME2 readthrough* / NME/NM23 nucleoside diphosphate kinase 2*  / complex






 

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